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Total 26 results found since Jan 2013.
Clinical presentation, diagnosis, and management of a primary cardiac tumor: A case report
CONCLUSIONS: For patients with malignant tumor, most of them had local invasion or had distant metastasis when the diagnosis was clear, and only conservative management could be done. Moreover, the prognosis of malignant tumor is poor, and the pathological morphology is diverse. The causes of death are due to widespread tumor metastasis, refractory heart failure, and various arrhythmias.PMID:37596232 | DOI:10.1016/j.asjsur.2023.07.099
Source: Asian Journal of Surgery - August 18, 2023 Category: Surgery Authors: Jianhua Xie Liang Yuan Yuxue Qin Jianxiong Liu Source Type: research
Metformin and Dapagliflozin Attenuate Doxorubicin-Induced Acute Cardiotoxicity in Wistar Rats: An Electrocardiographic, Biochemical, and Histopathological Approach
This study aimed to investigate the anticipated cardioprotective potential of metformin and dapagliflozin against doxorubicin-induced acute cardiotoxicity in Wistar rats. At the beginning of the experiment, cardiac screening of experimental animals was done by recording an electrocardiogram (ECG) before allocating them into the groups. Thereafter, a total of thirty healthy adult Wistar rats (150-200 g) were randomly divided into five groups (n = 6) and treated for eight days as follows: group I (normal control), group II (doxorubicin control), group III (metformin 250 mg/kg/day), group IV (metformin 180 mg/kg/day), and gro...
Source: Cardiovascular Toxicology - February 15, 2023 Category: Cardiology Authors: Shakta Mani Satyam Laxminarayana Kurady Bairy Prakashchandra Shetty P Sainath Sanjay Bharati Akheruz Zaman Ahmed Varun Kumar Singh A J Ashwal Source Type: research
Metformin alleviates prolonged isoflurane inhalation induced cognitive decline via reducing neuroinflammation in adult mice
In conclusion, prolonged sub-MAC isoflurane exposure triggered significant hippocampal neuroinflammation and cognitive decline in adult mice which can be alleviated by metformin pretreatment via inhibiting reactive microglia and A1-like astrocytes and promoting microglia polarization toward anti-inflammatory phenotype in the hippocampus.PMID:35709590 | DOI:10.1016/j.intimp.2022.108903
Source: International Immunopharmacology - June 16, 2022 Category: Allergy & Immunology Authors: Liangyu Peng Shuai Liu Jiyan Xu Wenjia Xie Xin Fang Tianjiao Xia Xiaoping Gu Source Type: research
Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats
Conclusion These findings suggest that the PVN and ARC participate in the beneficial effects of MET in T2D diabetic rats, which is possibly mediated via down-regulating of inflammatory molecules, attenuating oxidative stress and restoring the balance of neurotransmitter synthetase by MET in the PVN and ARC.PMID:35085591 | DOI:10.1016/j.taap.2022.115893
Source: Toxicology and Applied Pharmacology - January 27, 2022 Category: Toxicology Authors: Xiao-Jing Yu Yan-Mei Chen Xiao-Jing Liu Xiao-Jie Bai Kai-Li Liu Li-Yan Fu Hong-Li Gao Tian-Ze Sun Xiao-Lian Shi Jie Qi Ying Li Yu-Ming Kang Source Type: research
Metformin prevents airway hyperreactivity in rats with dietary obesity
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 20. doi: 10.1152/ajplung.00202.2021. Online ahead of print.ABSTRACTIncreased insulin is associated with obesity-related airway hyperreactivity and asthma. We tested whether the use of metformin, an anti-diabetic drug used to reduce insulin resistance, can reduce circulating insulin, thereby preventing airway hyperreactivity in rats with dietary obesity. Male and female rats were fed a high- or low-fat diet for 5 weeks. Some male rats were simultaneously treated with metformin (100 mg/kg, p.o.). In separate experiments, after 5 weeks of a high-fat diet, some rats were switched to...
Source: Am J Physiol Lung Ce... - October 20, 2021 Category: Respiratory Medicine Authors: Gina N Calco Becky J Proskocil David B Jacoby Allison D Fryer Zhenying Nie Source Type: research
