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Total 209 results found since Jan 2013.

Gestational Diabetes Mellitus: Update on Screening, Diagnosis, and Management
Am Fam Physician. 2023 Sep;108(3):249-258.ABSTRACTGestational diabetes mellitus (GDM) is a common condition of pregnancy with increasing prevalence in the United States. GDM increases risks of complications, including operative delivery, hypertensive disorders, shoulder dystocia, fetal macrosomia, large-for-gestational-age infants, neonatal hypoglycemia, and neonatal respiratory distress. In patients who are overweight or obese, prepregnancy weight loss and lifestyle modifications during pregnancy may prevent GDM. First-trimester screening can identify preexisting diabetes and early-onset GDM for prompt implementation of g...
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Joshua S Will Holly Crellin Source Type: research

Promising translatable pharmacological interventions for body weight management in individuals with severe mental illness - a narrative review
Expert Opin Pharmacother. 2023 Aug 31. doi: 10.1080/14656566.2023.2254698. Online ahead of print.ABSTRACTINTRODUCTION: Psychotropic medications, especially antipsychotics, have been consistently shown to cause weight gain in individuals with severe mental illness (SMI), a population inherently challenged with poor physical health. Consequently, compared to the general population, this contributes to an increased cardiometabolic burden, including the risk of type 2 diabetes, dyslipidemia, and hypertension. Furthermore, comorbid obesity leads to treatment nonadherence, decreased quality of life, and increased risk of relapse...
Source: Expert Opinion on Pharmacotherapy - September 1, 2023 Category: Drugs & Pharmacology Authors: Riddhita De Femin Prasad Nicolette Stogios Luisa Burin Bj ørn H Ebdrup Filip K Knop Margaret K Hahn Sri Mahavir Agarwal Source Type: research

The benefit of metformin in the treatment of pediatric non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials
Conclusion: According to the data of this meta-analysis, treatment with metformin failed to statistically improve liver enzymes but may be beneficial in the improvement of lipid parameters and insulin metabolism regulation in pediatric patients with NAFLD. As there are not enough available studies in the literature, the influence of metformin on liver ultrasonography or histology in pediatric NAFLD should be further analyzed in future studies.What is Known:• Lifestyle modification with weight loss through physical activity and dietary modification is the recommended treatment option for pediatric NAFLD.• Metformin may ...
Source: European Journal of Pediatrics - August 28, 2023 Category: Pediatrics Source Type: research

The impact of metformin with or without lifestyle modification versus placebo on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials
CONCLUSIONS: Metformin should be considered as an efficacious adjunct to lifestyle interventions in adults with PCOS, especially for those with a higher BMI, to improve weight loss, insulin resistance and lipids.PMID:37536294 | DOI:10.1093/ejendo/lvad098
Source: European Journal of Endocrinology - August 3, 2023 Category: Endocrinology Authors: Johanna Melin Maria Forslund Simon Alesi Terhi Piltonen Daniela Romualdi Poli Mara Spritzer Chau Thien Tay Alexia Pena Selma Feldman Witchel Aya Mousa Helena Teede Source Type: research

Pterostilbene ameliorates type-2 diabetes mellitus - induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain
Brain Res. 2023 Jul 19:148494. doi: 10.1016/j.brainres.2023.148494. Online ahead of print.ABSTRACTOne of the most serious mental health comorbidities associated with diabetes mellitus is depression. The occurrence is almost double in type 2 diabetes mellitus (T2DM) compared with the general population. Pterostilbene (PTE), a dimethylated analog of resveratrol, has been reported for significant neuroprotective, anti-inflammatory, hypolipidemic, hypoglycaemic and antioxidant effects. However, its effect on diabetes-induced depression-like behavior (DID) has not been studied. The current study aimed at studying the effects of...
Source: Brain Research - July 21, 2023 Category: Neurology Authors: Rashmi Patil Urmila Aswar Nishant Vyas Source Type: research

Pterostilbene ameliorates type-2 diabetes mellitus - Induced depressive-like behavior by mitigating insulin resistance, inflammation and ameliorating HPA axis dysfunction in rat brain
Brain Res. 2023 Jul 20;1817:148494. doi: 10.1016/j.brainres.2023.148494. Online ahead of print.ABSTRACTOne of the most serious mental health comorbidities associated with diabetes mellitus is depression. The occurrence is almost double in type 2 diabetes mellitus (T2DM) compared with the general population. Pterostilbene (PTE), a dimethylated analog of resveratrol, has been reported for significant neuroprotective, anti-inflammatory, hypolipidemic, hypoglycaemic and antioxidant effects. However, its effect on diabetes-induced depression-like behavior (DID) has not been studied. The current study aimed at studying the effec...
Source: Brain Research - July 21, 2023 Category: Neurology Authors: Rashmi Patil Urmila Aswar Nishant Vyas Source Type: research

Antiobesity effect of < em > Kaempferia parviflora < /em > accompanied by inhibition of lipogenesis and stimulation of lipolysis
CONCLUSIONS: PF treatment during the differentiation of 3T3-L1 cells suppressed adipogenesis and lipogenesis and PF treatment after differentiation activated lipolysis and thermogenesis. Thus, we suggest that PF is effective for weight loss by directly affecting the lipid metabolism of adipocytes.PMID:37441513 | PMC:PMC10335092 | DOI:10.29219/fnr.v67.9374
Source: Food and Nutrition Research - July 13, 2023 Category: Nutrition Authors: Seong-Hoo Park Jeongjin Park Minhee Lee Jinhak Kim Sangwon Eun Woojin Jun Ok-Kyung Kim Jeongmin Lee Source Type: research