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Considerations and Current Trends in the Management of the Geriatric Patient on a Consultation –Liaison Service
AbstractPurpose of ReviewTo provide consultation –liaison psychiatrists with an updated resource that can assist in the treatment and management of geriatric patients.Recent FindingsThe current available literature has not shown any differences in efficacy between haloperidol and second-generation antipsychotics in patients with delirium. When considering relative advantages of forms of antipsychotic administration, there is no support for a superior safety profile of oral compared to intramuscular or intravenous administration. A recent meta-analysis of four randomized controlled trials concluded that when melatonin was...
Source: Current Psychiatry Reports - April 12, 2020 Category: Psychiatry Source Type: research

Activation of 5-HT1A postsynaptic receptors by NLX-101 results in functional recovery and an increase in neuroplasticity in mice with brain ischemia
Publication date: Available online 3 December 2019Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Rafael Pazinatto Aguiar, Lígia Mendes Soares, Erika Meyer, Fernanda Canova da Silveira, Humberto Milani, Adrian Newman-Tancredi, Mark Varney, Jos Prickaerts, Rúbia M. Weffort de OliveiraAbstractPharmacological interventions that selectively activate serotonin 5-hydroxytryptramine-1A (5-HT1A) heteroreceptors may prevent or attenuate the consequences of brain ischemic episodes. The present study investigated whether the preferential 5-HT1A postsynaptic receptor agonist NLX-101 (a.k.a. F15599) m...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - December 4, 2019 Category: Psychiatry Source Type: research

The Search for Treatments for Veterans With Major Depression —Of Paramount Importance, yet Still Elusive
Remission rates in patients with major depressive disorder (MDD) remain unacceptably low. From the 28% to 33% remission rate in the Sequenced Treatment Alternatives to Relieve Depression (STAR-D*) Study after treatment with the selective serotonin reuptake inhibitor citalopram to the more recent Predicting Response to Depression Treatment (PReDICT) Study of treatment-naive patients with depression treated with escitalopram, duloxetine, or cognitive-behavioral therapy (CBT), with remission rates of approximately 50%, it is clear that a sizable number of patients with depression do not achieve remission, the universally ackn...
Source: JAMA Psychiatry - June 27, 2018 Category: Psychiatry Source Type: research

Prevention of Poststroke Mortality Using Problem-Solving Therapy or Escitalopram.
CONCLUSION: To the authors' knowledge, this is the first time a psychological antidepressant treatment administered for 1 year has been associated with increased survival among patients who have suffered a stroke. PMID: 28029510 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - December 30, 2016 Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research

Efficacy of early administration of escitalopram on depressive and emotional symptoms and neurological dysfunction after stroke: a multicentre, double-blind, randomised, placebo-controlled study
Publication date: January 2017 Source:The Lancet Psychiatry, Volume 4, Issue 1 Author(s): Jong S Kim, Eun-Jae Lee, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon Background Mood and emotional disturbances are common in patients with stroke, and adversely affect the clinical outcome. We aimed to evaluate the efficacy of early administration of escitalopram to reduce moderate or severe depressive symptoms and improve emotion...
Source: The Lancet Psychiatry - December 21, 2016 Category: Psychiatry Source Type: research

Table of Contents
Abstract Study of antidepressants finds modest effect on QT prolongation Reckitt blocked by FDA on buprenorphine, faces FTC inquiry SSRIs and tramadol: Possible link to serotonin syndrome Orexin receptor antagonist effective for insomnia Antipsychotics' receptor profiles linked to stroke risk FDA offers new guidance on developing drugs for Alzheimer's disease Common genetic variation and antidepressant efficacy Antipsychotics and weight change Pharmacogenetic study looks at cocaine abuse Polymorphism predicts escitalopram dose for depression D‐cycloserine impact on fear examined SSRI drugs and ischemic heart disease and ...
Source: The Brown University Psychopharmacology Update - April 9, 2013 Category: Psychiatry Source Type: research