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Specialty: Drugs & Pharmacology
Drug: Colcrys

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Total 16 results found since Jan 2013.

Is Colchicine Involved in Managing Stroke?
Curr Vasc Pharmacol. 2023 May 19. doi: 10.2174/1570161121666230519143716. Online ahead of print.NO ABSTRACTPMID:37211843 | DOI:10.2174/1570161121666230519143716
Source: Current Vascular Pharmacology - May 22, 2023 Category: Drugs & Pharmacology Authors: Antonio Siniscalchi Piergiorgio Lochner Giovambattista De Sarro Luca Gallelli Source Type: research

Pharmacotherapy for stroke prevention in nonvalvular atrial fibrillation: current strategies and future directions
This article reviews current pharmacotherapeutic options for prevention of stroke in NVAF, paying special attention to their use in particular clinical settings (e.g.: cardioversion, catheter ablation). We also aim to review new drug candidates that have entered clinical studies in this indication.EXPERT OPINION: Oral anticoagulant therapy (OAT) remains the mainstay for ischemic stroke prophylaxis in NVAF in patients at risk. Several oral (asundexian, milvexian) and parenteral (abelacimab, osocimab, xisomab, IONIS-FXIRX, fesomersen) factor XIa inhibitors are under development. These new compounds appear to be associated wi...
Source: Expert Opinion on Pharmacotherapy - November 18, 2022 Category: Drugs & Pharmacology Authors: Antonio G ómez-Outes M Luisa Su árez-Gea Alejandro-Isidoro P érez-Cabeza Jose Manuel Garc ía-Pinilla Source Type: research

Effect of different doses of colchicine on high sensitivity C-reactive protein in patients with acute minor stroke or transient ischemic attack: A pilot randomized controlled trial
CONCLUSION: Early treatment with low dose of colchicine reduced hsCRP levels in the patients with acute minor ischemic stroke and TIA.PMID:36041708 | DOI:10.1016/j.ejps.2022.106288
Source: European Journal of Pharmaceutical Sciences - August 30, 2022 Category: Drugs & Pharmacology Authors: Baoshi Yuan Xia Meng Anxin Wang Siying Niu Xuewei Xie Jing Jing Hao Li Liguo Chang Yongjun Wang Jiejie Li Source Type: research

Colchicine: An ancient drug with multiple benefits.
Abstract The history of colchicine dates to ancient Egyptians when it was used for alleviation of swelling and pain. Although its popularity varied throughout the years, colchicine has been a mainstay for the treatment of several diseases, mainly rheumatic and cardiac ones. The mechanism of action of the drug involves several intracellular and extracellular targets, although interaction with tubulin is the most described. Based on several clinical trials and meta-analyses, colchicine is safely recommended as a monotherapy or as an add-on for the treatment and prevention of recurrent pericarditis, postpericardiotom...
Source: Current Pharmaceutical Design - October 23, 2020 Category: Drugs & Pharmacology Authors: El Hasbani G, Jawad A, Uthman I Tags: Curr Pharm Des Source Type: research

Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 10, 2019 Category: Drugs & Pharmacology Source Type: research

Colchicine for Stroke Prevention: A Systematic Review and Meta-Analysis.
Abstract PURPOSE: There has been recent interest in the role of colchicine in cardiovascular diseases, given the implication of inflammation in the pathogenesis of atherothrombosis. This systematic review assessed the role of colchicine in preventing primary or secondary stroke/transient ischemic attack (TIA) in an adult population. METHODS: Four databases were electronically searched: MEDLINE, EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), and OpenGrey. Studies were eligible if they reported stroke or TIA incidence as a primary/secondary end point, or as an adverse event. Only case-control...
Source: Clinical Therapeutics - February 27, 2019 Category: Drugs & Pharmacology Authors: Khandkar C, Vaidya K, Patel S Tags: Clin Ther Source Type: research

The Role of Colchicine in the Prevention of Cerebrovascular Ischemia.
CONCLUSION: Inflammatory pathways seem to be key mediators in the development of atherosclerotic process, atheromatous plaque destabilization and thromboembolism. Colchicine as a novel therapeutic agent could be a safe and effective inhibitor of the inflammation cascade in patients with extra- or intracranial atherosclerosis or arteriolosclerosis, resulting in reduced vascular events. PMID: 29336246 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 15, 2018 Category: Drugs & Pharmacology Authors: Tsivgoulis G, Katsanos AH, Giannopoulos G, Panagopoulou V, Jatuzis D, Lemnens R, Deftereos S, Kelly PJ Tags: Curr Pharm Des Source Type: research

Colchicine in Neurosurgery.
CONCLUSION: Colchicine is a drug that over the years has shown promising results in certain neurosurgical entities. Its derivatives or potential colchicine-like agents might have a more significant place in neurosurgical practice. PMID: 29336254 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 14, 2018 Category: Drugs & Pharmacology Authors: Evangelos D, Dimitrios G, Marios TS Tags: Curr Pharm Des Source Type: research

Colchicine in post-operative Atrial Fibrillation: a review.
Abstract Post-operative atrial fibrillation (POAF) is a frequent entity increasing hospitalization duration, stroke and mortality. In the recent years, a few studies have sought to investigate the potential effect of colchicine in POAF prevention after cardiac surgery or catheter pulmonary vein isolation for AF. In the present review article, we intend to provide a synopsis of clinical practice guidelines, summarize and critically approach current evidence for or against colchicine as a means of POAF prevention. PMID: 29336253 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 14, 2018 Category: Drugs & Pharmacology Authors: Vrachatis DA, Kossyvakis C, Angelidis C, Panagopoulou V, Sarri EK, Giotaki S, Siasos G, Vavuranakis M, Deftereos SG Tags: Curr Pharm Des Source Type: research