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Drug: Actemra
Procedure: Transplants
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Total 209 results found since Jan 2013.
Tocilizumab increases regulatory T cells, reduces natural killer cells and delays graft-versus-host disease development in humanized mice treated with post-transplant cyclophosphamide
This study investigated the effect of tocilizumab (TOC) combined with post-transplant cyclophosphamide (PTCy) on immune cell engraftment and GVHD development in a humanized mouse model. NOD-scid-IL2Rγnull (NSG) mice were injected intraperitoneally with 2 × 107 human (h) peripheral blood mononuclear cells and cyclophosphamide (33 mg kg-1 ) or saline on days 3 and 4, then TOC or control antibody (0.5 mg mouse-1 ) twice weekly for 28 days. Mice were monitored for clinical signs of GVHD for either 28 or 70 days. Spleens and livers were assessed for human leukocyte subsets, and serum cytokines and tissue histology were analyz...
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: Chloe Sligar Peter Cuthbertson Nicole A Miles Sam R Adhikary Amal Elhage Geoff Zhang Stephen I Alexander Ronald Sluyter Debbie Watson Source Type: research
A Review of Current and Emerging Therapeutic Options for Hemophagocytic Lymphohistiocytosis
CONCLUSIONS: Improvements in diagnostic methods and novel immunosuppressive treatment strategies, including noncytotoxic immunochemotherapy, have transformed the therapeutic landscape. Unfortunately, many unanswered questions remain. Additional studies are required to optimize dosing, schedules, treatment sequences, and indications for novel treatment options.PMID:36349896 | DOI:10.1177/10600280221134719
Source: The Annals of Pharmacotherapy - November 9, 2022 Category: Drugs & Pharmacology Authors: Jenna Summerlin Drew A Wells Mary Kate Anderson Zachery Halford Source Type: research
Improving access to kidney transplantation for highly sensitized patients: What place for IL-6 pathway blockade in desensitization protocols?
CONCLUSION: IL-6 pathway blockade as a monotherapy fails to desensitize HLA highly sensitized kidney transplant candidates. In association with standard-of-care, it does not seem to significatively improve kidney allograft access (short-term efficacy) vs. standard-of-care only. However, it could improve long-term prognosis of HLA incompatible transplantation by orienting the response towards a tolerogenic profile, by hindering B-cell maturation and, thereby, avoiding DSA rebounds after transplantation. This hypothesis needs to be proven by further studies.PMID:36328901 | DOI:10.1016/j.nephro.2022.07.402
Source: Nephrologie and Therapeutique - November 3, 2022 Category: Urology & Nephrology Authors: Jules Weinhard Johan Noble Thomas Jouve Paolo Malvezzi Lionel Rostaing Source Type: research
Fever Characteristics and Impact on Safety and Efficacy of Chimeric Antigen Receptor T-Cell Therapy
CONCLUSION: While fever is common after CAR T-cell therapy, early-onset and higher magnitude do not appear to affect safety or efficacy of CAR T. Absence of fever may affect response to CAR T.PMID:36319568 | DOI:10.1016/j.clml.2022.09.005
Source: Clinical Lymphoma and Myeloma - November 1, 2022 Category: Cancer & Oncology Authors: James A Davis Kelly J Gaffney Mary McGann Deidra Smith Kathy Edwards Ellen Baldino Keegan Bakos Coleen Butcher Brian Greenwell Brian T Hess Hamza Hashmi Source Type: research
TWiV 949: Clinical update with Dr. Daniel Griffin
In his weekly clinical update Dr. Griffin discusses progress toward poliomyelitis eradication in Pakistan, polio by the numbers , influenza and COVID-19 vaccination coverage among health care personnel, phase 1/2a safety and immunogenicity of an adenovirus 26 vector RSV vaccine encoding prefusion F in adults 18–50 years and RSV seropositive children 12–24 months, receipt of first and second doses of JYNNEOS vaccine for prevention of Monkeypox, distinguishing SARS-CoV-2 persistence and reinfection, Novavax NVX-COV2373 triggers potent neutralization of Omicron sub-lineages, association between regular physical activity a...
Source: This Week in Virology - MP3 Edition - October 29, 2022 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Incidence of Coronavirus Infection in Patients Undergoing Kidney Transplant During the Pandemic Period in Uzbekistan
CONCLUSIONS: The Ministry of Health of the Republic of Uzbekistan indicated the possibility of treatment of patients with moderate and severe COVID-19 disease with monoclonal antibodies that block interleukin 6 receptors (tocilizumab and sarilumab). With timely detection of symptoms of COVID-19infection, treatment, and the use of prevention methods, kidney transplant recipients of living related donors had fewer complications of the disease than expected.PMID:36018027 | DOI:10.6002/ect.DonorSymp.2022.O15
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - August 26, 2022 Category: Transplant Surgery Authors: Fazlitdin Sh Bakhritdinov Ravshan A Ibadov Marguba T Azimova Zokhidjon T Matkarimov Dildora N Komilova Nigina B Elmurodova Source Type: research
