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Short chain fatty acids and monocarboxylate transporters in irritable bowel syndrome
CONCLUSION: In agreement with findings of previous studies, the microbiota assessed were significantly altered inferring dysbiosis in IBS. SCFA and their ratios were significantly altered in both IBS groups. SCFA transporters, MCT1 and SMCT1 were significantly reduced in both IBS groups, suggesting reduced colonocyte SCFA transfer. SCFA availability and transfer into the colonocytes may be important in IBS pathogenesis and should be prospectively studied.PMID:33625995 | PMC:PMC7928259 | DOI:10.5152/tjg.2020.19856
Source: The Turkish Journal of Gastroenterology - February 24, 2021 Category: Gastroenterology Authors: Ernst Fredericks Reza Theunissen Saartjie Roux Source Type: research
Protective effects of dried mature < em > Citrus unshiu < /em > peel (Chenpi) and hesperidin on aspirin-induced oxidative damage
J Clin Biochem Nutr. 2021 Mar;68(2):149-155. doi: 10.3164/jcbn.20-83. Epub 2020 Oct 13.ABSTRACTHere we investigated the inhibitory effects in rats of mature Citrus unshiu peel (Chenpi) and its component hesperidin on aspirin-induced oxidative damage. The content of hesperidin in Chenpi extract was approximately 11.4%. Wistar rats were orally administered Chenpi extract or hesperidin (20 mg/kg body weight) and then were orally administered aspirin (200 mg/kg body weight) to induce oxidative damage to the stomach, liver, and kidneys. Such damage was evaluated using the formamidopyrimidine DNA glycosylase-modified comet assay...
Source: Clinical Biochemistry - April 21, 2021 Category: Biochemistry Authors: Yuko Shimamura Shunsuke Sei Saori Nomura Shuichi Masuda Source Type: research
Short chain fatty acids and monocarboxylate transporters in irritable bowel syndrome
CONCLUSION: In agreement with findings of previous studies, the microbiota assessed were significantly altered inferring dysbiosis in IBS. SCFA and their ratios were significantly altered in both IBS groups. SCFA transporters, MCT1 and SMCT1 were significantly reduced in both IBS groups, suggesting reduced colonocyte SCFA transfer. SCFA availability and transfer into the colonocytes may be important in IBS pathogenesis and should be prospectively studied.PMID:33625995 | PMC:PMC7928259 | DOI:10.5152/tjg.2020.19856
Source: The Turkish Journal of Gastroenterology - February 24, 2021 Category: Gastroenterology Authors: Ernst Fredericks Reza Theunissen Saartjie Roux Source Type: research
Protective effects of dried mature < em > Citrus unshiu < /em > peel (Chenpi) and hesperidin on aspirin-induced oxidative damage
J Clin Biochem Nutr. 2021 Mar;68(2):149-155. doi: 10.3164/jcbn.20-83. Epub 2020 Oct 13.ABSTRACTHere we investigated the inhibitory effects in rats of mature Citrus unshiu peel (Chenpi) and its component hesperidin on aspirin-induced oxidative damage. The content of hesperidin in Chenpi extract was approximately 11.4%. Wistar rats were orally administered Chenpi extract or hesperidin (20 mg/kg body weight) and then were orally administered aspirin (200 mg/kg body weight) to induce oxidative damage to the stomach, liver, and kidneys. Such damage was evaluated using the formamidopyrimidine DNA glycosylase-modified comet assay...
Source: Clinical Biochemistry - April 21, 2021 Category: Biochemistry Authors: Yuko Shimamura Shunsuke Sei Saori Nomura Shuichi Masuda Source Type: research
Short chain fatty acids and monocarboxylate transporters in irritable bowel syndrome
CONCLUSION: In agreement with findings of previous studies, the microbiota assessed were significantly altered inferring dysbiosis in IBS. SCFA and their ratios were significantly altered in both IBS groups. SCFA transporters, MCT1 and SMCT1 were significantly reduced in both IBS groups, suggesting reduced colonocyte SCFA transfer. SCFA availability and transfer into the colonocytes may be important in IBS pathogenesis and should be prospectively studied.PMID:33625995 | PMC:PMC7928259 | DOI:10.5152/tjg.2020.19856
Source: The Turkish Journal of Gastroenterology - February 24, 2021 Category: Gastroenterology Authors: Ernst Fredericks Reza Theunissen Saartjie Roux Source Type: research
Protective effects of dried mature < em > Citrus unshiu < /em > peel (Chenpi) and hesperidin on aspirin-induced oxidative damage
J Clin Biochem Nutr. 2021 Mar;68(2):149-155. doi: 10.3164/jcbn.20-83. Epub 2020 Oct 13.ABSTRACTHere we investigated the inhibitory effects in rats of mature Citrus unshiu peel (Chenpi) and its component hesperidin on aspirin-induced oxidative damage. The content of hesperidin in Chenpi extract was approximately 11.4%. Wistar rats were orally administered Chenpi extract or hesperidin (20 mg/kg body weight) and then were orally administered aspirin (200 mg/kg body weight) to induce oxidative damage to the stomach, liver, and kidneys. Such damage was evaluated using the formamidopyrimidine DNA glycosylase-modified comet assay...
Source: Clinical Biochemistry - April 21, 2021 Category: Biochemistry Authors: Yuko Shimamura Shunsuke Sei Saori Nomura Shuichi Masuda Source Type: research
Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis
CONCLUSION: PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles.PMID:34025071 | PMC:PMC8117741 | DOI:10.3748/wjg.v27.i18.2160
Source: World Journal of Gastroenterology : WJG - May 24, 2021 Category: Gastroenterology Authors: Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa Zenta Yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito Source Type: research
Expression profile of seven polyamine oxidase genes in rice ( < em > Oryza sativa < /em > ) in response to abiotic stresses, phytohormones and polyamines
Physiol Mol Biol Plants. 2021 Jun;27(6):1353-1359. doi: 10.1007/s12298-021-01006-1. Epub 2021 May 28.ABSTRACTPolyamine levels are controlled by biosynthesis, intra- and inter-cellular flux by the respective transporters, and catabolism. The catabolism is catalyzed by two groups of enzymes. One is copper-containing amine oxidases and the other is polyamine oxidases (PAOs). In Oryza sativa, seven PAO genes exist and they are termed as OsPAO1 to OsPAO7. However, their physiological function has not been elucidated yet. Here, we examined the expressional changes of seven OsPAO genes upon abiotic and oxidative stress, phytohorm...
Source: Mol Biol Cell - July 5, 2021 Category: Molecular Biology Authors: G H M Sagor Masataka Inoue Tomonobu Kusano Thomas Berberich Source Type: research
Prolonged Maternal Separation Induces the Depression-Like Behavior Susceptibility to Chronic Unpredictable Mild Stress Exposure in Mice
Biomed Res Int. 2021 Jul 29;2021:6681397. doi: 10.1155/2021/6681397. eCollection 2021.ABSTRACTEarly life stress is an important determinant for developing depression later in life. It is reported that maternal separation (MS) could trigger stress sensitivity in adulthood when exposed to stress again. However, it could also result in resilience to stress-induced depression. The conclusions are contradictory. To address this issue, C57BL/6N newborn pups were exposed to either daily short MS (MS for 15 min per day; MS15) or prolonged MS (MS for 180 min per day; MS180) from the first day postpartum (PD1) to PD21. Adult mice we...
Source: Biomed Res - August 9, 2021 Category: Research Authors: Yaoyao Bian Yanting Ma Qian Ma Lili Yang Qinmei Zhu Wenlin Li Lingdong Meng Source Type: research
