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Trends in volume-regulated anion channel (VRAC) research: visualization and bibliometric analysis from 2014 to 2022
Conclusion: The aim of this bibliometric analysis is to provide an overall perspective for research on VRAC. VRAC has become a topic of increasing interest, and our analysis shows that it continues to be a prominent area. This study offers insights into the investigation of VRAC channel and may guide researchers in identifying new directions for future research.PMID:37538172 | PMC:PMC10394876 | DOI:10.3389/fphar.2023.1234885
Source: Atherosclerosis - August 4, 2023 Category: Cardiology Authors: Tianbao Liu Yin Li Dawei Wang Tobias Stauber Jiajun Zhao Source Type: research

Crosstalk between PI3K/AKT/mTOR and WNT/ β-Catenin signaling in GBM - Could combination therapy checkmate the collusion?
Cell Signal. 2022 May 4:110350. doi: 10.1016/j.cellsig.2022.110350. Online ahead of print.ABSTRACTGlioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by radio and chemotherapy employing temozolomide remains the gold-standard treatment for malignant glioma patients, the overall prognosis remains dismal and there exists an unmet need for effective therapeutic strategies. In this context, we hypothesize that proper understanding of signaling pathways responsible for glioblastoma multiforme proliferat...
Source: Cell Research - May 7, 2022 Category: Cytology Authors: S Daisy Precilla Indrani Biswas Shreyas S Kuduvalli T S Anitha Source Type: research

Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models For Predicting Therapeutic Response
CONCLUSION: We report the first methods to establish patient-derived mSDH tumor models, which can be readily employed for understanding patient-specific tumor biology and treatment strategies. We also demonstrate that temozolomide is effective in mSDH GIST patients who are refractory to existing chemotherapeutic drugs (namely TKIs) in clinic for GISTs, bringing a promising treatment option for these patients to clinic.PMID:34426440 | DOI:10.1158/1078-0432.CCR-21-2092
Source: Clinical Cancer Research - August 24, 2021 Category: Cancer & Oncology Authors: Mayra Yebra Shruti Bhargava Avi Kumar Adam M Burgoyne Chih-Min Tang Hyunho Yoon Sudeep Banerjee Joseph Aguilera Thekla Cordes Vipul Sheth Sangkyu Noh Rowan Ustoy Sam Li Sunil J Advani Christopher L Corless Michael C Heinrich Razelle Kurzrock Scott M Lippm Source Type: research

Temozolomide in grade III gastroenteropancreatic neuroendocrine neoplasms (G3 GEPNENs): A multicentre retrospective review
CONCLUSION: This is the largest TEM treatment series in G3 NEN, involving collaboration of several major North American NEN centers as a partnership. Thirty-six percent of patients showed some degree of radiographic response, and treatment was generally well-tolerated, although the median duration of response was short. Response rates and time to treatment failure were superior in the first-line setting. CAPTEM should be considered a viable treatment option in this setting. Further randomized trials are warranted.IMPLICATIONS FOR PRACTICE: Neuroendocrine neoplasms (NENs) are heterogeneous and optimal treatment for aggressi...
Source: The Oncologist - August 3, 2021 Category: Cancer & Oncology Authors: David L Chan Emily K Bergsland Jennifer A Chan Rujuta Gadgil Thorvardur R Halfdanarson Kathleen Hornbacker Virginia Kelly Pamela L Kunz Patrick W McGarrah Nitya P Raj Diane L Reidy Alia Thawer Julia Whitman Linda Wu Christoph Becker Simron Singh Source Type: research

Hematological Side Effects of Immune Checkpoint Inhibitors: The Example of Immune-Related Thrombocytopenia
Conclusion Hem-irAEs are potentially life-threatening complications of ICIs that require a high level of clinical suspicion. Ir-TCP is amongst the most frequently reported hem-irAEs. Due to its low incidence and the lack of specific diagnostic criteria, ir-TCP may be underdiagnosed and possibly underreported. The diagnosis is based on exclusion of other causes of TCP together with clinical features that suggest an immune event such as the refractoriness to platelet transfusions and response to corticosteroids. During clinical development, a systematic analysis of ir-TCP cases at clinical study and program level is of outm...
Source: Frontiers in Pharmacology - April 25, 2019 Category: Drugs & Pharmacology Source Type: research

Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis
In conclusion, our WGCNA analysis identified candidate prognostic biomarkers for further basic and clinical researches. Introduction Breast cancer is a frequently diagnosed malignancy and the leading cause of cancer death among females around the world, accounting for 24% of cancer diagnoses and 15% of cancer deaths in females. According to Global Cancer Statistics 2018, there will be nearly 2.1 million new cases diagnosed globally, with ~62 thousand deaths. The incident rates of breast cancer increased in most developing countries during last decades, resulting from a combination of social and economic facto...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research