Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis

In conclusion, our WGCNA analysis identified candidate prognostic biomarkers for further basic and clinical researches. Introduction Breast cancer is a frequently diagnosed malignancy and the leading cause of cancer death among females around the world, accounting for 24% of cancer diagnoses and 15% of cancer deaths in females. According to Global Cancer Statistics 2018, there will be nearly 2.1 million new cases diagnosed globally, with ~62 thousand deaths. The incident rates of breast cancer increased in most developing countries during last decades, resulting from a combination of social and economic factors, including the postponement of childbearing, obesity, and physical inactivity (1). In the developed countries, the incidence of breast cancer is markedly higher, while nearly 60% of deaths occur in the developing counties. It is becoming a major health burden in both developed and developing countries. Prognosis of patients with breast cancer has been improved as a result of recent advances of radiotherapy, hormone therapy, chemotherapy, and immunotherapy. However, quite a few patients diagnosed and treated at early stages unfortunately suffer from locoregional or distant tumor recurrence (2, 3). Breast cancer is a heterogeneous disease, and it is widely acknowledged that inheritance plays important roles in the initiation and progression of breast cancer. During the past decade, molecular studies demonstrated that there were at least 4 molecular subtypes of bre...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

Related Links:

Publication date: 2020Source: Computational and Structural Biotechnology Journal, Volume 18Author(s): Zhilan Zhang, Lin Li, Mengyuan Li, Xiaosheng Wang
Source: Computational and Structural Biotechnology Journal - Category: Biotechnology Source Type: research
Cancer-fighting Kronos and Spruce, targeting a serious hormonal condition, have a common investor in Omega Funds.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 19 September 2020Source: Molecular Phylogenetics and EvolutionAuthor(s): Jun Chen, Yan-Fei Zeng, Da-Yong Zhang
Source: Molecular Phylogenetics and Evolution - Category: Molecular Biology Source Type: research
Publication date: Available online 19 September 2020Source: Life SciencesAuthor(s): Lang Guan Cun, Muhammad Waseem Ghani, Zhao Yi, Wu Jiang, Li Ye, Liu Bin, Muhammad Waseem Birmani, An Lilong, Xiao Mei
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 18 September 2020Source: Chemico-Biological InteractionsAuthor(s): J. Priyanga, B. Sharan Kumar, R. Mahalakshmi, K. Nirekshana, P. Vinoth, Vellaisamy Sridharan, Dipita Bhakta-Guha, Gunjan Guha
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: December 2020Source: Microchemical Journal, Volume 159Author(s): Muthumariappan Akilarasan, Selvarasu Maheshwaran, Tse-Wei Chen, Shen-Ming Chen, Elayappan Tamilalagan, M. Ajmal Ali, Wedad A. Al-onazi, Amal M. Al-Mohaimeed
Source: Microchemical Journal - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2020Source: Chinese Chemical LettersAuthor(s): Yangyi Gu, Ling Miao, Ying Yin, Mingxian Liu, Lihua Gan, Liangchun Li
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 19 September 2020Source: Chinese Chemical LettersAuthor(s): Yuanqing Sun, Yiming Ouyang, Jiaqing Luo, Huihui Cao, Xiang Li, Jingwen Ma, Jian Liu, Yuanhao Wang, Lin Lu
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 18 September 2020Source: Chinese Chemical LettersAuthor(s): Shumu Li, Jian’an Liu, Jiping Sun, Zhenpeng Wang, Kai Wang, Lei Guo, Shuliang Yang, Jinchao Wei, Xiangjun Zheng, Zhenwen Zhao
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
Publication date: Available online 18 September 2020Source: Chinese Chemical LettersAuthor(s): Panpan Zhang, Shang Xue, Pengfei Tang, Zhirong Cui, Zefan Wang, Jun Luo, Lingyi Kong
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
More News: Academia | Adenocarcinoma | Bone Cancers | Brain | Brain Cancers | Brain Tumor | Breast Cancer | Breast Carcinoma | Breast Surgery | Cancer | Cancer & Oncology | Carcinoma | Carcinoma in Situ | Chemotherapy | Child Development | China Health | Colorectal Cancer | Databases & Libraries | DCIS (Ductal Carcinoma in Situ) | Docetaxel | Ductal Carcinoma | Eating Disorders & Weight Management | Endocrine Therapy | Epithelial Cancer | Genetics | Glioma | Hepatocellular Carcinoma | HER2 | Herceptin | Hormonal Therapy | Hormones | Immunotherapy | Liver Cancer | Lung Cancer | Medical Ethics | Men | Molecular Biology | Neurology | Non-Small Cell Lung Cancer | Obesity | Osteosarcoma | Ovarian Cancer | Ovaries | Pancreas | Pancreatic Cancer | Pathology | Prostate Cancer | Reproduction Medicine | Science | Smokers | Statistics | Stem Cell Therapy | Stem Cells | Students | Study | Surgery | Tamoxifen | Taxotere | Temodar | Thyroid | Thyroid Cancer | Universities & Medical Training | Urology & Nephrology | USA Health | Women | Xeloda