Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis

In conclusion, our WGCNA analysis identified candidate prognostic biomarkers for further basic and clinical researches. Introduction Breast cancer is a frequently diagnosed malignancy and the leading cause of cancer death among females around the world, accounting for 24% of cancer diagnoses and 15% of cancer deaths in females. According to Global Cancer Statistics 2018, there will be nearly 2.1 million new cases diagnosed globally, with ~62 thousand deaths. The incident rates of breast cancer increased in most developing countries during last decades, resulting from a combination of social and economic factors, including the postponement of childbearing, obesity, and physical inactivity (1). In the developed countries, the incidence of breast cancer is markedly higher, while nearly 60% of deaths occur in the developing counties. It is becoming a major health burden in both developed and developing countries. Prognosis of patients with breast cancer has been improved as a result of recent advances of radiotherapy, hormone therapy, chemotherapy, and immunotherapy. However, quite a few patients diagnosed and treated at early stages unfortunately suffer from locoregional or distant tumor recurrence (2, 3). Breast cancer is a heterogeneous disease, and it is widely acknowledged that inheritance plays important roles in the initiation and progression of breast cancer. During the past decade, molecular studies demonstrated that there were at least 4 molecular subtypes of bre...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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In conclusion, this review reported that IL-37 has a crucial role in reducing infection-associated inflammation and has a good impact on inflammation-induced pathology. However, tight regulation that achieved balance between effector immune responses that required for pathogen elimination and limited tissue damage that resulted from excessive inflammation should be existed in the potential IL-37 therapy to prevent clinical complications of a disease. PMID: 31633447 [PubMed - as supplied by publisher]
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
Date: Wednesday, 10 30, 2019; Speaker: Hyunsoo Shawn Je, Prof., Duke-NUS Medical School; Building: Building 5; 127
Source: NIH Calendar of Events - Category: American Health Source Type: events
Date: Tuesday, 11 12, 2019; Speaker: Meira Epplein, PhD, Associate Professor in Population Health Sciences, Associate Prof in Medicine, Department of Medicine, Duke University School of Medicine ; http://epi.grants.cancer.gov/events/infectious-age
Source: NIH Calendar of Events - Category: American Health Source Type: events
Conclusions: The results indicate that a possible mechanism behind an anastomotic leakage is an impaired circulation and thus insufficient saturation to the small intestine peroperatively. This develops into an inflammation both intraperitoneally and intravenously, which, if not reversed, spread within the gastrointestinal tract .The colorectal anastomosis is the most vulnerable part of the gastrointestinal tract postoperatively and hypoxia and inflammation may occur there, and an anastomosis leakage will be the consequence. PMID: 31630578 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
ConclusionRRA must be initiated within 58 days after surgery in patients with high-risk DTCs. Under this approach, risk of SIR and associated mortality risk may be reduced. RRA timing for women in reproductive ages with low/intermediate risk groups may be planned according to their pregnancy/breastfeeding intent. For other low/intermediate risk groups, they can safely proceed according to the capacity of the medical facility and related logistical considerations.ResumenIntroducciónEs difícil adoptar un enfoque científico basado en la evidencia con respecto al intervalo de aplicación de la ablaci...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
ConclusionsFrom the results it can be concluded that there indeed exists correlation between striking and struck vehicles in side crashes, although the correlation is not so strong. Importantly, Bayesian bivariate probit model can address the role of striking and struck vehicles in side crashes simultaneously and can accommodate the correlation clearly, which extends the range of univariate probit analysis. The general and empirical countermeasures are presented to improve the safety at intersections.
Source: Accident Analysis and Prevention - Category: Accident Prevention Source Type: research
Publication date: Available online 22 October 2019Source: Stem Cell ResearchAuthor(s): Jonathan Arias-Fuenzalida, Jingwei Yu, Likun Du, Joaquin Custodio, Luigi D. Notarangelo, Lennart Hammarström, Qiang Pan-HammarströmAbstractSelective immunoglobulin-A deficiency (IgAD) is the most common primary immunodeficiency (PID) in the Western world and results in higher susceptibility to infections, autoimmune disorders and malignancies. We generated human induced pluripotent stem cell lines from two patients with selective immunoglobulin-A primary immunodeficiency, PHAi001 and PHAi002. Patient samples were reprogrammed u...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 21 October 2019Source: Stem Cell ResearchAuthor(s): T.A. Shnaider, I.E. Pristyazhnyuk, A.G. Menzorov, N.M. Matveeva, A.A Khabarova, N.A. Skryabin, A.A. Kashevarova, M.E. Lopatkina, L.P. Nazarenko, I.N. Lebedev, O.L. SerovAbstractThe human induced pluripotent stem cell (iPSC) lines, ICGi009-A, ICGi009-B, ICGi013-A and ICGi013-B, were generated from skin fibroblasts of two siblings with intellectual disability. Both patients were carriers of CNTN6 gene microdeletion(Kashevarova et al., 2014). iPSC lines have normal karyotype, express pluripotency markers, are able to differentiate in vitro ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 21 October 2019Source: Stem Cell ResearchAuthor(s): Haiyan Zhang, Yanyan Ma, Shujuan Yu, Xiaomeng Yang, Yue Li, Jingyun Guan, Rui Dong, Zhongtao Gai, Yi LiuAbstractWe established an induced pluripotent stem cell (iPSC) line (SDQLCHi010-A) from peripheral blood mononuclear cells isolated from a 4-year-old boy with optic nerve malformation and intellectual disability carrying a heterozygous mutation (c.220A>G (p.S74G)) in PAX6 gene. Non-integrating episomal vectors containing OCT4, SOX2, KLF4, BCL-XL and MYC were used for reprogramming. The established iPSC line showed normal karyotype, ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 21 October 2019Source: Stem Cell ResearchAuthor(s): Chanchao Lorthongpanich, Nittaya Jiamvoraphong, Prapasri Supakun, Nattaya Damkham, Papussorn Terbto, Supaporn Waeteekul, Yaowalak U-pratya, Chuti Laowtammathron, Surapol IssaragrisilAbstractWWTR1 or TAZ (WWTR1/TAZ) is a transcriptional coactivator that acts as a downstream regulatory target in the Hippo signaling pathway, which plays a pivotal role in regulating cell proliferation and anti-apoptosis. It has been shown in other cell types that WWTR1/TAZ plays a redundant role to its homolog YAP1. Using CRISPR/Cas9 gene editing, we establi...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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