Overexpression of ASPM, CDC20, and TTK Confer a Poorer Prognosis in Breast Cancer Identified by Gene Co-expression Network Analysis
In conclusion, our WGCNA analysis identified candidate prognostic biomarkers for further basic and clinical researches. Introduction Breast cancer is a frequently diagnosed malignancy and the leading cause of cancer death among females around the world, accounting for 24% of cancer diagnoses and 15% of cancer deaths in females. According to Global Cancer Statistics 2018, there will be nearly 2.1 million new cases diagnosed globally, with ~62 thousand deaths. The incident rates of breast cancer increased in most developing countries during last decades, resulting from a combination of social and economic factors, including the postponement of childbearing, obesity, and physical inactivity (1). In the developed countries, the incidence of breast cancer is markedly higher, while nearly 60% of deaths occur in the developing counties. It is becoming a major health burden in both developed and developing countries. Prognosis of patients with breast cancer has been improved as a result of recent advances of radiotherapy, hormone therapy, chemotherapy, and immunotherapy. However, quite a few patients diagnosed and treated at early stages unfortunately suffer from locoregional or distant tumor recurrence (2, 3). Breast cancer is a heterogeneous disease, and it is widely acknowledged that inheritance plays important roles in the initiation and progression of breast cancer. During the past decade, molecular studies demonstrated that there were at least 4 molecular subtypes of bre...
Publication date: 2020Source: Computational and Structural Biotechnology Journal, Volume 18Author(s): Zhilan Zhang, Lin Li, Mengyuan Li, Xiaosheng Wang
Cancer-fighting Kronos and Spruce, targeting a serious hormonal condition, have a common investor in Omega Funds.
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