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Specialty: Drugs & Pharmacology
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Total 300 results found since Jan 2013.
Bioinformatics analysis of wild-type ParC and S79F, S79Y mutations in Streptococcus pneumoniae
CONCLUSIONS: It is believed that the change in physicochemical properties caused by the mutation altered the conformation of the quinolone binding region and the bond types, numbers, and proximities of the amino acids involved in the interaction with the active substance. The results obtained from the modeling performed in this study with visualization and analysis of possible conformational, hydrophobic, and volumetric changes of only ParC mutations provided data and literature support to elucidate the mechanism. The molecular docking and PLIP results obtained in this study support both the homology modeling results and t...
Source: Pharmacological Reviews - August 22, 2023 Category: Drugs & Pharmacology Authors: B Akg ün Karapınar O Oflaz Source Type: research
Nine Insights From 10 Years of Legal Cannabis for Nonmedical Purposes
Clin Ther. 2023 Jun;45(6):496-505. doi: 10.1016/j.clinthera.2023.03.005.ABSTRACTWhereas the 20th century could be largely characterized as the age of cannabis prohibition, the 21st century may ultimately be known as the era of cannabis legalization. Although several countries and subnational jurisdictions have relaxed laws to allow cannabis to be used for medical purposes, the policy landscape shifted dramatically in 2012 when voters in Colorado and Washington passed ballot initiatives to allow cannabis to be sold to adults for nonmedical purposes. Since then, Canada, Uruguay, and Malta have legalized nonmedical cannabis, ...
Source: Clinical Therapeutics - July 6, 2023 Category: Drugs & Pharmacology Authors: Beau Kilmer Samantha P érez-Dávila Source Type: research
Network Pharmacology and Molecular Docking to Unveil the Mechanism of Shudihuang Against Amyotrophic Lateral Sclerosis
CONCLUSION: In summary, this study suggested that the main active components of Shudihuang (stigmasterol and sitosterol) may exert a critical effect in ALS treatment by binding to hub targets (PTGS2, PPARG, ESR1, IGF-1R, and MAPK3) and then modulating estrogen receptor-related pathways to attenuate glutamate excitotoxicity, inhibit oxidative stress and antagonize inflammation.PMID:37345246 | DOI:10.2174/1381612829666230621105552
Source: Current Pharmaceutical Design - June 22, 2023 Category: Drugs & Pharmacology Authors: Xiaojing Li Yueqin Tian Haidong Wu Tong Wang Source Type: research
The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice
Eur J Pharmacol. 2023 Jun 15:175832. doi: 10.1016/j.ejphar.2023.175832. Online ahead of print.ABSTRACTThe onset and progression of Alzheimer's disease (AD) are influenced by a variety of factors. These include oxidative stress, overexpression of acetylcholinesterase (AChE), depletion of acetylcholine levels, increased beta-secretase mediated conversion of Amyloid Precursor Protein (APP) to Amyloid Beta (Abeta), accumulation of Abeta oligomers, decrease in Brain Derived Neurotrophic factor (BDNF) and accelerated neuronal apoptosis due to elevated levels of caspase-3. The currently available therapeutic approaches are inadeq...
Source: European Journal of Pharmacology - June 17, 2023 Category: Drugs & Pharmacology Authors: Abhinav Anand Navneet Khurana Satinder Kaur Nemat Ali Abdullah F AlAsmari Mohammad Waseem Muzaffar Iqbal Faris M Alzahrani Neha Sharma Source Type: research
Betanin improves motor function and alleviates experimental Parkinsonism via downregulation of TLR4/MyD88/NF- κB pathway: Molecular docking and biological investigations
In this study, we investigated the neuroprotective action of betanin in the rotenone-induced Parkinson-like mice model. Twenty-eight adult male Swiss albino mice were divided into four groups: Vehicle, Rotenone, Rotenone + Betanin 50 mg/kg, and Rotenone + Betanin 100 mg/kg. Parkinsonism was induced by subcutaneous injection of 9 doses of rotenone (1 mg/kg/48 h) plus betanin at 50 and 100 mg/kg/48 h in rotenone + betanin groups for twenty days. Motor dysfunction was assessed after the end of the therapeutic period using the pole, rotarod, open-field, grid, and cylinder tests. Malondialdehyde, reduced glutathione (GSH), Toll...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 27, 2023 Category: Drugs & Pharmacology Authors: Mohamed H ElSayed Huda M Atif Mohamed Ahmed Eladl Samah M Elaidy Ahmed M N Helaly Fatma Azzahraa Hisham Noha E Farag Noura M S Osman Afaf T Ibrahiem Heba W Z Khella Shymaa E Bilasy Marzough Aziz Albalawi Mohamed A Helal Wafa Ali Alzlaiq Sawsan A Zaitone Source Type: research
Vitamin E and A increase the passing of the P-gp substrate ivermectin into the brain in mice
This study aimed to determine the effect of oral Vitamin A and E administrations at different doses on plasma and brain concentrations of ivermectin in mice. The study was carried out on 174 Swiss Albino male mice aged 8-10 weeks. After leaving 6 mice for method validation, the remaining mice were randomly divided into 7 groups with equal numbers of animals. Mice received ivermectin (0.2 mg/kg, subcutaneous) alone and in combination with low (Vit A; 4,000 IU/kg, Vit E; 35 mg/kg) and high (Vit A; 30,000 IU/kg, Vit E; 500 mg/kg) oral doses of Vit A and E. The plasma and brain concentrations of ivermectin were measured using ...
Source: Canadian Journal of Physiology and Pharmacology - May 26, 2023 Category: Drugs & Pharmacology Authors: Bunyamin Tras Kamil Uney Tugba Melike Parlak Oznur Tufan Source Type: research
