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Fight Aging! Newsletter, August 21st 2023
This study aimed to investigate the association between frailty index and circulating CAP2 concentration in 467 community-dwelling older adults (median age: 79; range: 65-92 years). The selected robust regression model showed that circulating CAP2 concentration was not associated with chronological age, as well as sex and education. However, circulating CAP2 concentration was significantly and inversely associated with the frailty index: a 0.1-unit increase in frailty index leads to ~0.5-point mean decrease in CAP2 concentration. Furthermore, mean CAP2 concentration was significantly lower in frail participants (i.e., fr...
Source: Fight Aging! - August 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Impact of AI system on recognition for anatomical landmarks related to reducing bile duct injury during laparoscopic cholecystectomy
CONCLUSION: The AI system provided significant awareness to beginners and experts and prompted them to identify anatomical landmarks linked to reducing BDI.PMID:37365396 | DOI:10.1007/s00464-023-10224-5
Source: Hand Surgery - June 26, 2023 Category: Surgery Authors: Yuichi Endo Tatsushi Tokuyasu Yasuhisa Mori Koji Asai Akiko Umezawa Masahiro Kawamura Atsuro Fujinaga Aika Ejima Misako Kimura Masafumi Inomata Source Type: research

Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechani...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

National Surveillance of Pediatric Acute Hepatitis of Unknown Etiology, Japan, October 2021-December 2022
Emerg Infect Dis. 2023 Jun;29(6):1288-1291. doi: 10.3201/eid2906.221579.ABSTRACTPediatric acute hepatitis of unknown etiology has been reported globally since April 2022. In Japan, 139 possible cases with onset dates after October 2021 were reported as of December 2022. Three patients required liver transplants, but none died. Rates of adenovirus positivity (11/125, 9%) were lower than those for other countries.PMID:37209697 | DOI:10.3201/eid2906.221579
Source: Emerging Infectious Diseases - May 20, 2023 Category: Infectious Diseases Authors: Shogo Otake Chiaki Ikenoue Natsu Sudani Miho Kobayashi Kensuke Takahashi Tomoe Shimada Itsuro Yoshimi Tomoya Saito Tomimasa Sunagawa Source Type: research

Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Changes in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transplant Patients in Japan: A Longitudinal Survey Study
Ann Transplant. 2022 Dec 6;27:e938239. doi: 10.12659/AOT.938239.NO ABSTRACTPMID:36471640 | DOI:10.12659/AOT.938239
Source: Annals of Transplantation - December 6, 2022 Category: Transplant Surgery Authors: Satomi Tanaka Kimie Fujita Kanako Yakushiji Noboru Harada Tomoharu Yoshizumi Source Type: research

Marginal parental donors for pediatric living donor liver transplantation
Curr Opin Organ Transplant. 2022 Aug 1;27(4):346-350. doi: 10.1097/MOT.0000000000000990.ABSTRACTPURPOSE OF REVIEW: Living donor liver transplantation (LT) has been increasingly recognized as an effective treatment modality with excellent patient survival. Indications for LT have evolved not only for cholestatic liver disease, but also metabolic liver diseases. Living donor selection, particularly for pediatric inherited disease, is essential to prevent morbidity, both in the donor and recipient.RECENT FINDINGS: Based on 30 years of experience in pediatric living donor LT in Japan, we could identify marginal parental living...
Source: Current Opinion in Organ Transplantation - November 10, 2022 Category: Transplant Surgery Authors: Mureo Kasahara Seisuke Sakamoto Akinari Fukuda Hajime Uchida Nam-Joon Yi Andrea Schlegel Paolo Muiesan Xia Qiang Wei Gao Zhi-Jun Zhu Manuel Rodriguez-Davalos Mohamed Rela Source Type: research

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