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Total 54934 results found since Jan 2013.

Genetic analysis of suppressor mutants of a pho84 disruptant in the search for genes involved in intracellular inorganic phosphate sensing in Saccharomyces cerevisiae.
Abstract To achieve inorganic phosphate (Pi) homeostasis, cells must be able to sense intracellular and extracellular Pi concentrations. In the Pi signaling (PHO) pathway in Saccharomyces cerevisiae, high Pi represses genes involved in Pi uptake (e.g., PHO84) and Pi utilization (PHO5); conversely, the cyclin-dependent kinase inhibitor Pho81 inhibits the activity of the Pho80-Pho85 cyclin-cyclin dependent kinase complex in low-Pi conditions, leading to induction of these genes. However, how yeast senses Pi availability remains unresolved. To identify factors involved in Pi sensing upstream of the Pho81-Pho80-Pho85 ...
Source: Genes and Genetic Systems - November 16, 2018 Category: Genetics & Stem Cells Authors: Sasano Y, Sakata T, Okusaki S, Sugiyama M, Kaneko Y, Harashima S Tags: Genes Genet Syst Source Type: research

A direct dark matter search in XMASS-I
Publication date: Available online 5 December 2018Source: Physics Letters BAuthor(s): K. Abe, K. Hiraide, K. Ichimura, Y. Kishimoto, K. Kobayashi, M. Kobayashi, S. Moriyama, M. Nakahata, T. Norita, H. Ogawa, K. Sato, H. Sekiya, O. Takachio, A. Takeda, S. Tasaka, M. Yamashita, B.S. Yang, N.Y. Kim, Y.D. Kim, Y. ItowAbstractA search for dark matter using an underground single-phase liquid xenon detector was conducted at the Kamioka Observatory in Japan, particularly for Weakly Interacting Massive Particles (WIMPs). We have used 705.9 live days of data in a fiducial volume containing 97kg of liquid xenon at the center of the d...
Source: Physics Letters B - December 5, 2018 Category: Physics Source Type: research

Search for Protein Tyrosine Phosphatase 1B Inhibitors from Marine Organisms and Induced Production of New Fungal Metabolites by Modulating Culture Methods.
Abstract Marine environments offer a rich source of natural products with potential therapeutic applications because the ocean covers 70% of the earth's surface and approximately 80% of all living organisms live in the sea. Therefore we have investigated bioactive compounds from marine organisms such as marine sponges, ascidians, and marine-derived microorganisms. This review consists of two topics based on marine natural product chemistry. (1) Protein tyrosine phosphatase (PTP) 1B plays a key role as a negative regulator in the insulin and leptin signaling pathways. Accordingly, the development of PTP1B inhibitor...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - May 8, 2019 Category: Drugs & Pharmacology Authors: Yamazaki H Tags: Yakugaku Zasshi Source Type: research

Search for Therapeutic Agents for Cardiac Arrest Using a Drug Discovery Tool and Large-Scale Medical Information Database
The survival rate of cardiac arrest patients is less than 10%; therefore, development of a therapeutic strategy that improves their prognosis is necessary. Herein, we searched data collected from medical facilities throughout Japan for drugs that improve the survival rate of cardiac arrest patients. Candidate drugs, which could improve the prognosis of cardiac arrest patients, were extracted using “TargetMine,” a drug discovery tool. We investigated whether the candidate drugs were among the drugs administered within 1 month after cardiac arrest in data of cardiac arrest cases obtained from the Japan Medical Data Cente...
Source: Frontiers in Pharmacology - November 7, 2019 Category: Drugs & Pharmacology Source Type: research

The Democrats' Search for a New Foreign Policy
A. Trevor Thrall andJordan CohenCato will be hosting a panel discussion on January 28,The Future of Progressive Foreign Policy: 2020 and Beyond, featuringKate Kizer from Win Without War, Loren DeJonge Schulman from the Center for a New American Security,Dan Nexon from Georgetown University,Adam Mount from the Federation of American Scientists, andMena Ayazi from the Alliance for Peacebuilding.To provide some broad perspective for the discussion, we are sharing a slightly updated version of an article wepublished in the November/December issue of the German magazine,Internationale Politik. In it we use speeches and campaign...
Source: Cato-at-liberty - January 16, 2020 Category: American Health Authors: A. Trevor Thrall, Jordan Cohen Source Type: blogs

Unraveling the Pathogenesis of Inflammatory Bowel Disease and Search for New Therapeutic Medicines.
We reported that the enhancement of IL-10 production by intestinal macrophages has the potential to be a novel therapeutic mechanism for maintaining the remission of IBD. Thus, to develop new therapeutic medicines for IBD, we screened the Wakanyaku Library derived from medicinal herbs for the ability to enhance IL-10 production by intestinal macrophages. Some compounds were identified with the potential to enhance IL-10 production by intestinal macrophages and thereby maintain long-term remission in IBD. This review focuses on our recent findings on the role of intestinal macrophages in the pathogenesis of IBD and developi...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - February 6, 2020 Category: Drugs & Pharmacology Authors: Hayashi S Tags: Yakugaku Zasshi Source Type: research

Search for Neuroprotective Compounds -From 4-Methycatechol to Citrus Compounds.
Abstract In the 1980s, the authors developed the enzyme immunoassay (EIA) system for mouse nerve growth factor (NGF) to clarify its important physiological roles. Our EIA system was a new and powerful tool for measurement of extremely low levels of NGF in vitro and in vivo, and it contributed to investigation into the regulatory mechanism of NGF synthesis. After that, we demonstrated that the compounds with a low molecular weight, such as 4-methylcatechol, which elicit stimulatory activity toward NGF synthesis, were useful and practical for therapeutic purposes; as NGF has potent activity on neuronal degeneration ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 6, 2021 Category: Drugs & Pharmacology Authors: Furukawa Y Tags: Yakugaku Zasshi Source Type: research

IJERPH, Vol. 18, Pages 3444: A Search for Causes of Rising Incidence of Differentiated Thyroid Cancer in Children and Adolescents after Chernobyl and Fukushima: Comparison of the Clinical Features and Their Relevance for Treatment and Prognosis
oph Reiners The incidence of differentiated thyroid cancer (DTC) is steadily increasing globally. Epidemiologists usually explain this global upsurge as the result of new diagnostic modalities, screening and overdiagnosis as well as results of lifestyle changes including obesity and comorbidity. However, there is evidence that there is a real increase of DTC incidence worldwide in all age groups. Here, we review studies on pediatric DTC after nuclear accidents in Belarus after Chernobyl and Japan after Fukushima as compared to cohorts without radiation exposure of those two countries. According to the Chernobyl data, r...
Source: International Journal of Environmental Research and Public Health - March 26, 2021 Category: Environmental Health Authors: Valentina Drozd Vladimir Saenko Daniel I. Branovan Kate Brown Shunichi Yamashita Christoph Reiners Tags: Review Source Type: research

Search of official nationwide database in Japan for adverse events associated with disease-modifying antirheumatic drug therapies: focus on therapies in combination with methotrexate
CONCLUSION: LPD was by far the most frequent AE associated with MTX therapy. PCP was strongly associated with combination MTX. For any of the other four DMARDs, i-Pn was most frequent.PMID:34762577 | DOI:10.1080/14740338.2022.2006180
Source: Expert Opinion on Drug Safety - November 11, 2021 Category: Drugs & Pharmacology Authors: Shigeko Inokuma Source Type: research

Internet search analysis on the treatment of rheumatoid arthritis: What do people ask and read online?
ConclusionsThe questions were most frequently related to the timeline of treatment and clinical course. Physicians should provide such information to patients with RA in the counseling and education materials.
Source: PLoS One - September 22, 2023 Category: Biomedical Science Authors: Satoshi Yamaguchi Source Type: research

The Search for Citrus Components with Neuroprotective and Anti-dementia Effects in the Mouse Brain
Yakugaku Zasshi. 2021;141(6):819-824. doi: 10.1248/yakushi.20-00251-1.ABSTRACTCitrus kawachiensis (Kawachi Bankan), is a citrus species grown in Ehime, Japan, and its peel is abundant in 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF). We have recently revealed that HMF, one of the citrus flavonoids, has anti-inflammatory activity and neuroprotective abilities in the brain against global cerebral ischemia. HMF rescued neuronal cell death in the hippocampus and suppressed the activation of microglia, whose activation have been shown to significantly aggravate neurological deficit scores for ischemic mice. In the Y-maze test, HMF ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 3, 2021 Category: Drugs & Pharmacology Authors: Satoshi Okuyama Atsushi Sawamoto Mitsunari Nakajima Yoshiko Furukawa Source Type: research