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Total 2970 results found since Jan 2013.

Serum basic fibroblast growth factor and interleukin-1 β predict the effect of first-line chemotherapy in patients with advanced gastric cancer
CONCLUSION: The FLOT regimen was effective in reducing the serum CEA, CA199, and TPS levels as well as in improving the 1-year survival rate of patients with good tolerability, making it worthy of clinical promotion and application.PMID:37731570 | PMC:PMC10507556 | DOI:10.12998/wjcc.v11.i26.6083
Source: Cancer Control - September 21, 2023 Category: Cancer & Oncology Authors: Li Zheng Li-Hong Gan Ling Yao Bin Li Ya-Qin Huang Fu-Bao Zhang Meng-Qi Kuang Nian Fang Source Type: research

Multi-element Exposure and Cognitive Function in Rural Elderly Chinese
Biol Trace Elem Res. 2023 Sep 16. doi: 10.1007/s12011-023-03774-1. Online ahead of print.ABSTRACTTo investigate the relationship between selenium (Se) based multi-element combined exposure and cognitive function in rural elderly individuals, a cross-sectional study was conducted. The study involved 416 older adults aged 60 and above, residing in four different areas of Enshi county, China, with varying soil Se levels. Inductively coupled plasma mass spectrometry (ICP-MS) was employed to measure the concentrations of Se, copper (Cu), iron (Fe), zinc (Zn), calcium (Ca), magnesium (Mg), cadmium (Cd), arsenic (As), and lead (P...
Source: Biological Trace Element Research - September 16, 2023 Category: Biology Authors: Lidan Duan Liqin Su Xiaohong He Yegang Du Yanying Duan Ning Xu Rangpeng Wu Yunfeng Zhu Ranqi Shao Frederick W Unverzagt Ann M Hake Yinlong Jin Sujuan Gao Source Type: research

Prevalence and predictors of vitamin D deficiency among adults with epilepsy: A cross-sectional study
CONCLUSION: Vitamin D deficiency among PWE is prevalent in our local population, suggesting that regular screening should be considered for those at risk. Early identification would allow intervention to reduce the risk of future complications.PMID:37716324 | DOI:10.1016/j.yebeh.2023.109432
Source: Epilepsy and Behaviour - September 16, 2023 Category: Neurology Authors: Ching Soong Khoo Mohd Fadzli Shukor Juen Kiem Tan Michelle Maryanne Tan Li Ling Yong Siti Zaleha Sahibulddin Siti Hajar Mat Desa Norasyikin A Wahab Rozita Hod Hui Jan Tan Source Type: research

Study on the correlation and interaction between metals and dyslipidemia: a case-control study in Chinese community-dwelling elderly
Environ Sci Pollut Res Int. 2023 Sep 16. doi: 10.1007/s11356-023-29695-z. Online ahead of print.ABSTRACTPrevious studies on the association between metals and dyslipidemia are not completely consistent. There are few studies investigating the relationship between mixed metal exposure and dyslipidemia as well as the effects of metals on dyslipidemia in community-dwelling elderly. To evaluate the correlations and interaction effect between the urinary concentrations of metals and the risk of dyslipidemia in community-dwelling elderly. We designed a case-control study to assess the correlation between urine metals and dyslipi...
Source: Environmental Science and Pollution Research International - September 16, 2023 Category: Environmental Health Authors: Zhongyuan Zhang Rui Wang Pei He Yuqing Dai Siyu Duan Meiyan Li Zhuoheng Shen Xiaoyu Li Jian Sun Source Type: research

Model-Informed Dosing Regimen of Ticagrelor in Chinese Patients with Acute Coronary Syndrome
Clin Pharmacol Ther. 2023 Sep 13. doi: 10.1002/cpt.3048. Online ahead of print.ABSTRACTThe exposure to ticagrelor is higher in the East Asian population compared to the Caucasian population, thus, East Asians have an increased risk of bleeding. We developed a population pharmacokinetic model of ticagrelor based on a randomized 3 × 3 crossover study in healthy subjects. The area under concentration-time curve (AUC) of Chinese patients with acute coronary syndrome was simulated based on this model. Following this, eight machine learning methods were used to construct bleeding risk models. Variables included in the final ble...
Source: Clinical Pharmacology and Therapeutics - September 13, 2023 Category: Drugs & Pharmacology Authors: Yaxin Liu Yun Kuang Min Hai Cheng Cui Dongyang Liu Guoping Yang Source Type: research

“The Greatest Scientist of All Time” says Scientific American. Who is it?
BY MIKE MAGEE When it comes to our earthly survival as a human species, words are often under-powered and off-the-mark. Clearer concepts, definitions and terms are required for clarity. Here are five terms that are useful and worth remembering: Planetary Boundaries Earth Systems Human Perturbations Planetary Scale Destabilization Holocene Epoch vs. Anthropogenic Epoch  These terms all tie back to a single source – a child of World War II, only seven when his home in Amsterdam was overrun by Nazis. His father was a waiter, his mother a cook in a local hospital. He’d later recall with a sh...
Source: The Health Care Blog - September 11, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Non-Health Chemistry Mike Magee Ozone Paul Crutzen Scientific American Source Type: blogs

Mechanism of Lingbao Huxin Dan in the treatment of bradyarrhythmia complicated with coronary heart disease: a network pharmacology analysis
CONCLUSION: RBA-CHD may treat BA-CHD by regulating adrenergic receptor beta-1, alpha 1-α adrenergic receptor, calcium voltage-gated channel subunit alpha1 C, alpha-1β-adrenergic receptor, nitric oxide synthase 2, beta-2 adrenergic receptor, voltage-dependent calcium channel subunit alpha-2/delta-1, an- giotensin-converting enzyme, Raf-1 proto-oncogene serine/threonine-protein kinase, and other targets, potentially by affecting adrenergic receptor binding and calcium channel opening, to regulate the activity of cardiomyocytes.PMID:37679988 | PMC:PMC10465840 | DOI:10.19852/j.cnki.jtcm.20230802.001
Source: Journal of Traditional Chinese Medicine - September 8, 2023 Category: Complementary Medicine Authors: Han Huagang L I Ziqiang Ouyang Jingfeng Wang Tianquan Dong Lingyan Cao Junling Source Type: research