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Specialty: Neurology
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Total 119 results found since Jan 2013.

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study
Publication date: June 2018Source: The Lancet Neurology, Volume 17, Issue 6Author(s): Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins, Daniel J Serie, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Adolfo López de Munain, Miren Zulaica, Fermin Moreno, Isabelle Le Ber, Florence Pasquier, Didier Hannequin, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Tammee M Parsons, NiCole A FinchSummaryBackgroundLoss-of-function mutations in GRN cause frontotemporal lobar degeneration (FTLD). Patients with GRN mutations present with a uniform subtype of TAR DNA-binding protein 43 (TDP-43) patholog...
Source: The Lancet Neurology - July 5, 2018 Category: Neurology Source Type: research

Biological and Behavioral Patterns of Post-Stroke Depression in Rats.
CONCLUSION: The UFC analysis supports the behavioral analysis and thus, lends validity to our results. PMID: 29880078 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - June 8, 2018 Category: Neurology Authors: Ifergane G, Boyko M, Frank D, Shiyntum HN, Grinshpun J, Kuts R, Geva AB, Kaplan Z, Zeldetz V, Cohen H Tags: Can J Neurol Sci Source Type: research

Restenosis and risk of stroke after stenting or endarterectomy for symptomatic carotid stenosis in the International Carotid Stenting Study (ICSS): secondary analysis of a randomised trial
This report presents a secondary analysis, and follow-up is complete. Findings Between May, 2001, and October, 2008, 1713 patients were enrolled and randomly allocated treatment (855 were assigned stenting and 858 endarterectomy), of whom 1530 individuals were followed up with ultrasound (737 assigned stenting and 793 endarterectomy) for a median of 4·0 years (IQR 2·3–5·0). At least moderate restenosis (≥50%) occurred in 274 patients after stenting (cumulative 5-year risk 40·7%) and in 217 after endarterectomy (29·6%; unadjusted hazard ratio [HR] 1·43, 95% CI 1·21–1·72; p<0·0001). Patients with at lea...
Source: The Lancet Neurology - June 1, 2018 Category: Neurology Source Type: research

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study
Publication date: Available online 30 April 2018 Source:The Lancet Neurology Author(s): Cyril Pottier, Xiaolai Zhou, Ralph B Perkerson, Matt Baker, Gregory D Jenkins, Daniel J Serie, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Adolfo López de Munain, Miren Zulaica, Fermin Moreno, Isabelle Le Ber, Florence Pasquier, Didier Hannequin, Raquel Sánchez-Valle, Anna Antonell, Albert Lladó, Tammee M Parsons, NiCole A Finch, Elizabeth C Finger, Carol F Lippa, Edward D Huey, Manuela Neumann, Peter Heutink, Matthis Synofzik, Carlo Wilke, Robert A Rissman, Jaroslaw Slawek, Emilia Sitek, Peter Johannsen, Jørgen E Nielsen, Yi...
Source: The Lancet Neurology - May 1, 2018 Category: Neurology Source Type: research

Prevalence of Poststroke Neurocognitive Disorders Using National Institute of Neurological Disorders and Stroke-Canadian Stroke Network, VASCOG Criteria (Vascular Behavioral and Cognitive Disorders), and Optimized Criteria of Cognitive Deficit Clinical Sciences
Conclusions—This study is the first to have optimized the operationalization of the criterion for poststroke cognitive impairment. It documented the prevalence of poststroke NCD in the GRECOG-VASC cohort and showed that mild cognitive impairment accounts for 80% of the affected patients. Finally, the method developed in the present study offers a means of harmonizing the diagnosis of NCD.Clinical Trial Registration—URL: https://www.clinicaltrials.gov. Unique identifier: NCT01339195.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Melanie Barbay, Herve Taillia, Claudine Nedelec–Ciceri, Flavie Bompaire, Camille Bonnin, Jerome Varvat, Francoise Grangette, Momar Diouf, Emmanuel Wiener, Jean–Louis Mas, Martine Roussel, Olivier Godefroy Tags: Cognitive Impairment Original Contributions Source Type: research

Outcomes in Hospitalized Ischemic Stroke Patients with Dementia on Admission: A Population-Based Cohort Study.
This study sought to understand the prevalence of dementia in hospitalized patients with ischemic stroke, and its impact on outcomes. METHODS: Using the Canadian Institute of Health Information's (CIHI) Discharge Abstract Database (DAD), all acute ischemic stroke admissions from April 2003 to March 2015 in Canada (excluding Quebec) were analyzed. Concurrent dementia at the time of admission was assessed based on hospital diagnostic codes. Characteristics and in-hospital outcomes were compared in patients with and without dementia using χ 2 and negative binomial, as well as Poisson regression analysis. RESULTS: D...
Source: The Canadian Journal of Neurological Sciences - April 16, 2018 Category: Neurology Authors: Zerna C, Lindsay MP, Fang J, Swartz RH, Smith EE Tags: Can J Neurol Sci Source Type: research

The clinical utility of a 30-minute neuropsychological assessment battery in inpatient stroke rehabilitation
Cognitive assessment is an important component of inpatient stroke rehabilitation. Few studies have empirically evaluated the clinical utility of specific neuropsychological measures in this setting. We investigated the psychometric properties and clinical utility of a 30-minute neuropsychological battery developed by the National Institute of Neurologic Disorders and Stroke (NINDS) and the Canadian Stroke Network (CSN). Clinical data were analyzed from 100 individuals with mild-moderate stroke severity on an acute inpatient rehabilitation unit who completed the NINDS-CSN battery at admission.
Source: Journal of the Neurological Sciences - April 9, 2018 Category: Neurology Authors: Abhishek Jaywant, Joan Toglia, Faith M. Gunning, Michael W. O'Dell Source Type: research

Excessive sedentary time during in-patient stroke rehabilitation.
Conclusions In this sample of people attending inpatient stroke rehabilitation, institutional structure of rehabilitation rather than patient-related factors contributed to sedentary time. PMID: 29609499 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - April 3, 2018 Category: Neurology Authors: Barrett M, Snow JC, Kirkland MC, Kelly LP, Gehue M, Downer MB, McCarthy J, Ploughman M Tags: Top Stroke Rehabil Source Type: research

Population-based study of home-time by stroke type and correlation with modified Rankin score
Conclusions: We showed that home-time is an objective and graded indicator that is correlated with disability after stroke. It is obtainable from administrative data, applicable to different stroke types, and a valuable outcome indicator in population-based health services research.
Source: Neurology - November 6, 2017 Category: Neurology Authors: Yu, A. Y. X., Rogers, E., Wang, M., Sajobi, T. T., Coutts, S. B., Menon, B. K., Hill, M. D., Smith, E. E. Tags: Outcome research, Medical care, Infarction, Intracerebral hemorrhage ARTICLE Source Type: research

Pharmacists as Care Providers for Stroke Patients: A Systematic Review.
CONCLUSIONS: Available evidence suggests that a variety of pharmacist interventions can have a positive impact on stroke patient outcomes. Pharmacists should be considered an integral member of the stroke patient care team. PMID: 28929979 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - September 20, 2017 Category: Neurology Authors: Basaraba JE, Picard M, George-Phillips K, Mysak T Tags: Can J Neurol Sci Source Type: research

Upgoing thumb sign: A sensitive indicator of brain involvement?
Conclusions: An upgoing thumb sign is a sensitive and reliable indicator of brain involvement. This examination is noninvasive, easy, reliable, and highly compatible with and confirmatory of the patient's symptoms.
Source: Neurology - July 24, 2017 Category: Neurology Authors: Hachinski, V., Alsubaie, R., Azarpazhooh, M. R. Tags: ARTICLE Source Type: research

Prevalence of Fabry Disease and Outcomes in Young Canadian Patients With Cryptogenic Ischemic Cerebrovascular Events Clinical Sciences
Conclusions—In this Canadian cohort of patients with cryptogenic IS or TIA, the prevalence of Fabry was 0.3% if p.R118C variant is considered as pathogenic. This suggests that more cost-effective methods should be applied for diagnosis of Fabry rather than systematic genetic screening in this population. Overall, cryptogenic IS in young adults is associated with favorable outcomes.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Sylvain Lanthier, Gustavo Saposnik, Gerald Lebovic, Karen Pope, Daniel Selchen, David F. Moore, on behalf of the Canadian Fabry Stroke Screening Initiative Study Group Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA), Vascular Disease Original Contributions Source Type: research

Contralesional Brain-Computer Interface Control of a Powered Exoskeleton for Motor Recovery in Chronic Stroke Survivors Clinical Sciences
Conclusions—The findings demonstrate the therapeutic potential of a BCI-driven neurorehabilitation approach using the unaffected hemisphere in this uncontrolled sample of chronic stroke survivors. They also demonstrate that BCI-driven neurorehabilitation can be effectively delivered in the home environment, thus increasing the probability of future clinical translation.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT02552368.
Source: Stroke - June 26, 2017 Category: Neurology Authors: David T. Bundy, Lauren Souders, Kelly Baranyai, Laura Leonard, Gerwin Schalk, Robert Coker, Daniel W. Moran, Thy Huskey, Eric C. Leuthardt Tags: Rehabilitation, Cerebrovascular Disease/Stroke Original Contributions Source Type: research