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Total 115645 results found since Jan 2013.

American Journal of Transplantation Images in Transplantation—Continuing Medical Education (CME)
Source: American Journal of Transplantation - May 30, 2013 Category: Transplant Surgery Authors: C. M. Jones, R. A. Zaring, M. Eng Tags: Images in Transplantation Source Type: research

Waldenström macroglobulinemia: 2013 update on diagnosis, risk stratification, and management
Disease OverviewWaldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, and lymphadenopathy. DiagnosisThe presence of IgM monoclonal protein associated with ≥10% clonal lymphoplasmacytic cells in bone marrow confirms the diagnosis. Risk StratificationAge, hemoglobin level, platelet count, β2 microglobulin, and monoclonal IgM concentrations are characteristics required for prognosis. Risk‐Adapted TherapyNot all patients who fulfill WM criteria require therapy; these patients can be observe...
Source: American Journal of Hematology - June 20, 2013 Category: Hematology Authors: Morie A. Gertz Tags: Annual Clinical Updates in Hematological Malignancies: A Continuing Medical Education Series Source Type: research

Chronic myelomonocytic leukemia: 2013 update on diagnosis, risk stratification, and management
Disease overviewChronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder that is classified as a myelodysplastic/myeloproliferative neoplasm by the 2008 World Health Organization classification of hematopoietic tumors. It is characterized by absolute monocytosis (>1 × 109/L) in the peripheral blood that persists for at least 3 months. DiagnosisThe diagnosis of CMML rests on a combination of morphologic, histopathologic and chromosomal abnormalities in the bone marrow. It is important to exclude other myeloproliferative neoplasms and infectious/autoimmune conditions that can cause monocyto...
Source: American Journal of Hematology - October 24, 2013 Category: Hematology Authors: Sameer A. Parikh, Ayalew Tefferi Tags: Annual Clinical Updates in Hematological Malignancies: A Continuing Medical Education Series Source Type: research

Mantle cell lymphoma: 2013 Update on diagnosis, risk‐stratification, and clinical management
Disease OverviewMantle cell lymphoma (MCL) is a non‐Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood, and bone marrow with a short remission duration to standard therapies and a median overall survival of 4–5 years. DiagnosisDiagnosis is based on lymph node, bone marrow, or tissue morphology of centrocytic lymphocytes, small cell type, or blastoid variant cells. A chromosomal translocation t(11:14) is the molecular hallmark of MCL, resulting in the overexpression of cyclin D1. Cyclin D1 is detected by immunohistochemistry in 98% of cases. The absence of SOX‐11 or a low Ki‐67 may corre...
Source: American Journal of Hematology - November 22, 2013 Category: Hematology Authors: Julie M. Vose Tags: Annual Clinical Updates in Hematological Malignancies: A Continuing Medical Education Series Source Type: research

JACS CME Featured Articles, Volume 218, March 2014
Increasing age and survival after orthotopic liver transplantation for patients with hepatocellular cancer Kim J, Ko ME, Nelson RA, et al
Source: Journal of the American College of Surgeons - February 19, 2014 Category: Surgery Tags: Continuing Medical Education Program Source Type: research

Exam 2: Impact of the Hepatopulmonary Syndrome MELD Exception Policy on Outcomes of Patients After Liver Transplantation: An Analysis of the UNOS Database
Source: Gastroenterology - March 24, 2014 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Transplant for sickle cell disease and thalassemia
Source: Blood - May 15, 2014 Category: Hematology Tags: CME article CONTINUING MEDICAL EDUCATION (CME) QUESTIONS Source Type: research

Hodgkin lymphoma: 2014 update on diagnosis, risk‐stratification, and management
Disease overview: Hodgkin lymphoma (HL) is an uncommon B‐cell lymphoid malignancy affecting 9,200 new patients annually and representing approximately 11.5% of all lymphomas in the United States. Diagnosis: HL is composed of two distinct disease entities; the more commonly diagnosed classical HL and the rare nodular lymphocyte‐predominant HL. Nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte‐rich HL are subgroups under the designation of classical HL. Risk stratification: An accurate assessment of the stage of disease in patients with HL is critical for the selection of the appropriate therap...
Source: American Journal of Hematology - June 20, 2014 Category: Hematology Authors: Stephen M. Ansell Tags: A Continuing Medical Education Series Source Type: research

Cutaneous T‐cell lymphoma: 2014 Update on diagnosis, risk‐stratification, and management
Disease overview: Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data. Risk‐adapted therapy: TNMB (tumor, node, metastasis, and blood) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin‐directed ...
Source: American Journal of Hematology - July 14, 2014 Category: Hematology Authors: Ryan A. Wilcox Tags: A Continuing Medical Education Series Source Type: research

Multiple myeloma: 2014 Update on diagnosis, risk‐stratification, and management
Disease overview: Multiple myeloma accounts for approximately 10% of hematologic malignancies. Diagnosis: The diagnosis requires 10% or more clonal plasma cells on bone marrow examination or a biopsy proven plasmacytoma plus evidence of associated end‐organ damage. If end‐organ damage is not present, the presence of 60% or more clonal plasma cells in the marrow is also considered as myeloma. Risk stratification: In the absence of concurrent trisomies, patients with 17p deletion, t(14;16), and t(14;20) are considered to have high‐risk myeloma. Patients with t(4;14) translocation are considered intermediate‐risk. All...
Source: American Journal of Hematology - September 16, 2014 Category: Hematology Authors: S. Vincent Rajkumar Tags: A Continuing Medical Education Series Source Type: research

Acute myeloid leukemia: 2014 Update on risk‐stratification and management
Overview: Evidence suggest that even patients aged 70 or above benefit from specific AML therapy. The fundamental decision in AML then becomes whether to recommend standard or investigational treatment. This decision must rest on the likely outcome of standard treatment. Hence we review factors that predict treatment related mortality and resistance to therapy, the latter the principal cause of failure even in patients aged 70 or above. We emphasize the limitations of prediction of resistance based only on pre‐treatment factors and stress the need to incorporate post‐treatment factors, for example indicators of minimal...
Source: American Journal of Hematology - October 16, 2014 Category: Hematology Authors: Elihu H. Estey Tags: A Continuing Medical Education Series Source Type: research

Exam 1: A Mutation in the Hepatitis E Virus RNA Polymerase Promotes its Replication and Associates with Ribavirin Treatment Failure in Organ Transplant Recipients
Source: Gastroenterology - September 26, 2014 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activity Source Type: research

The kidney in HIV infection: beyond HIV-associated nephropathy.
This article summarizes a presentation by Christina M. Wyatt, MD, at the IAS-USA continuing medical education program held in Chicago in May 2012, describing AKI and CKD using case illustrations. PMID: 22954611 [PubMed - indexed for MEDLINE]
Source: Topics in antiviral medicine - November 12, 2014 Category: Infectious Diseases Tags: Top Antivir Med Source Type: research

Exam 1: Development of Fecal Microbiota Transplantation Suitable for Mainstream Medicine
Source: Clinical Gastroenterology and Hepatology - December 8, 2014 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research

Exam 1: Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States
Source: Gastroenterology - January 23, 2015 Category: Gastroenterology Tags: Continuing Medical Education (CME) Activities Source Type: research