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Specialty: Biomedical Science
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Total 883 results found since Jan 2013.
Aging decreases docosahexaenoic acid transport across the blood-brain barrier in C57BL/6J mice
by Takuro Iwao, Fuyuko Takata, Junichi Matsumoto, Hisataka Aridome, Miho Yasunaga, Miki Yokoya, Yasufumi Kataoka, Shinya Dohgu
Nutrients are actively taken up by the brain via various transporters at the blood–brain barrier (BBB). A lack of specific nutrients in the aged brain, including decreased levels of docosahexaenoic acid (DHA), is associated with memory and cognitive dysfunction. To compensate for decreased brain DHA, orally supplied DHA must be transported from the circulating blood to the brain across the BBB through transport carriers, including major facilitator superfamily domain-containing protein 2a (MFSD2...
Source: PLoS One - February 16, 2023 Category: Biomedical Science Authors: Takuro Iwao Source Type: research
Differential effects of < i > WRAP53 < /i > transcript variants on non-small cell lung cancer cell behaviors
ConclusionsWRAP53 transcript variants exerted different functions in non-small cell lung cancer cells and regulated non-small cell lung cancer cell behaviors depending on the p53 expression.
Source: PLoS One - January 27, 2023 Category: Biomedical Science Authors: Yan Zhu Source Type: research
ODF2L acts as a synthetic lethal partner with WEE1 inhibition in epithelial ovarian cancer models
WEE1 has emerged as an attractive target in epithelial ovarian cancer (EOC), but how EOC cells may alter their sensitivity to WEE1 inhibition remains unclear. Here, through a cell cycle machinery–related gene RNAi screen, we found that targeting outer dense fiber of sperm tails 2–like (ODF2L) was a synthetic lethal partner with WEE1 kinase inhibition in EOC cells. Knockdown of ODF2L robustly sensitized cells to treatment with the WEE1 inhibitor AZD1775 in EOC cell lines in vitro as well as in xenografts in vivo. Mechanistically, the increased sensitivity to WEE1 inhibition upon ODF2L loss was accompanied by accumulated...
Source: Journal of Clinical Investigation - January 18, 2023 Category: Biomedical Science Authors: Jie Li, Jingyi Lu, Manman Xu, Shiyu Yang, Tiantian Yu, Cuimiao Zheng, Xi Huang, Yuwen Pan, Yangyang Chen, Junming Long, Chunyu Zhang, Hua Huang, Qingyuan Dai, Bo Li, Wei Wang, Shuzhong Yao, Chaoyun Pan Source Type: research
Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47
KRAS is one of the most frequently activated oncogenes in human cancers. Although the role of KRAS mutation in tumorigenesis and tumor maintenance has been extensively studied, the relationship between KRAS and the tumor immune microenvironment is not fully understood. Here, we identified a role of KRAS in driving tumor evasion from innate immune surveillance. In samples of lung adenocarcinoma from patients and Kras-driven genetic mouse models of lung cancer, mutant KRAS activated the expression of cluster of differentiation 47 (CD47), an antiphagocytic signal in cancer cells, leading to decreased phagocytosis of cancer ce...
Source: Journal of Clinical Investigation - January 18, 2023 Category: Biomedical Science Authors: Huanhuan Hu, Rongjie Cheng, Yanbo Wang, Xiaojun Wang, Jianzhuang Wu, Yan Kong, Shoubin Zhan, Zhen Zhou, Hongyu Zhu, Ranran Yu, Gaoli Liang, Qingyan Wang, Xiaoju Zhu, Chen-Yu Zhang, Rong Yin, Chao Yan, Xi Chen Source Type: research
Doxorubicin induced ROS-dependent HIF1 α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis
In this study, we investigated the role of IGFBP3, HIF1A, and PHD in Dox-induced cardiac apoptosis. Cells challenged with 1 μM Dox for 24 h increased ROS generation, augmented intracellular and secreted IGFBP3 levels, and reduced IGF1 signaling. Further, we showed that Dox enhanced the extracellular association of IGF1 with IGFBP3. Moreover, echocardiography parameters, especially ejection fraction (EF) and fractional shortening (FS) were significantly reduced in ventricle tissue of Dox challenged rats. Notably, siRNA approach against IGFBP3 or an anti-IGFBP3 antibody rescued Dox-induced cardiac apoptosis, mitochondrial R...
Source: Aging - January 5, 2023 Category: Biomedical Science Authors: Su-Ying Wen Ayaz Ali I-Chieh Huang Jian-Sheng Liu Po-Yuan Chen Vijaya Padma Viswanadha Chih-Yang Huang Wei-Wen Kuo Source Type: research
PLAC8 contributes to the malignant behaviors of cervical cancer cells by activating the SOX4-mediated AKT pathway
This study aimed to explore the function and regulatory mechanism of PLAC8 in CC. Bioinformatics and immunohistochemical analyses demonstrated that PLAC8 was significantly upregulated in CC tissues compared with normal tissues. Gain/loss-of-function experiments showed that siRNA-mediated knockdown of PLAC8 suppressed cell migration and invasion, while PLAC8 overexpression promoted cell motility. Moreover, PLAC8 was revealed to affect the epithelial –mesenchymal transition (EMT) process by upregulating epithelial (E)-cadherin and decreasing the expression of mesenchymal markers of EMT, including vimentin, zinc finger E-bo...
Source: Histochemistry and Cell Biology - January 5, 2023 Category: Biomedical Science Source Type: research
C-C motif chemokine ligand 2 promotes myogenesis of myoblasts via the AKT-mTOR pathway
In conclusion, CCL2 positively affects myogenesis by CCR2 via AKT-mTOR signaling pathways. CCL2 might have potential as a therapeutic target for low muscle mass and muscle recovery.PMID:36575043 | DOI:10.18632/aging.204451
Source: Aging - December 27, 2022 Category: Biomedical Science Authors: Mi Kyung Kwak Eun Suk Ha Jiwoo Lee Yun Mi Choi Beom-Jun Kim Eun-Gyoung Hong Source Type: research
Decreased VEGFA alleviates the symptoms of LPS-induced sepsis in a mouse model by inhibiting glycolysis and thereby regulating the polarization of macrophages
This study demonstrates that decreased VEGFA inhibits glycolysis and thus inhibits LPS-induced M1 polarization of macrophages, ultimately relieving sepsis.
Source: European Journal of Histochemistry - December 22, 2022 Category: Biomedical Science Authors: Jun Lin, Liping Jiang, Kun Guo, Ning Feng Source Type: research
Ganglioside GD1a enhances osteogenesis by activating ERK1/2 in mesenchymal stem cells of < em > Lmna < /em > mutant mice
Aging (Albany NY). 2022 Nov 14;14. doi: 10.18632/aging.204378. Online ahead of print.ABSTRACTMutations in Lmna usually cause a series of human disorders, such as premature aging syndrome (progeria) involving the skeletal system. Gangliosides are known to be involved in cell surface differentiation and proliferation of stem cells. However, the role of gangliosides in Lmna dysfunctional mesenchymal stem cells (MSCs) is unclear. Therefore, Ganglioside's role in osteogenesis of Lmna dysfunctional MSCs analyzed. As a result of the analysis, it was confirmed that the expression of ganglioside GD1a was significantly reduced in MS...
Source: Aging - November 14, 2022 Category: Biomedical Science Authors: Dong Hoon Kwak Ji Hye Park Eul Sig Choi Seong Hyun Park Seo-Yeon Lee Seoul Lee Source Type: research
