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Therapy: Immunotherapy

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Total 36235 results found since Jan 2013.

Current Role and Future Perspectives of Immunotherapy and Circulating Factors in Treatment of Biliary Tract Cancers
Int J Med Sci. 2023 May 11;20(7):858-869. doi: 10.7150/ijms.82008. eCollection 2023.ABSTRACTBiliary tract cancers (BTCs) are a heterogenous group of malignancies arising from the epithelial cells of the biliary tree and the gallbladder. They are often locally advanced or already metastatic at the time of the diagnosis and therefore prognosis remains dismal. Unfortunately, the management of BTCs has been limited by resistance and consequent low response rate to cytotoxic systemic therapy. New therapeutic approaches are needed to improve the survival outcomes for these patients. Immunotherapy, one of the newest therapeutic o...
Source: International Journal of Medical Sciences - June 16, 2023 Category: Biomedical Science Authors: Simone Conci Giovanni Catalano Diletta Roman Camilla Zecchetto Eleonora Lucin Mario De Bellis Marzia Tripepi Alfredo Guglielmi Michele Milella Andrea Ruzzenente Source Type: research

Cancers, Vol. 15, Pages 4245: Immunotherapy for Colorectal Cancer with High Microsatellite Instability: The Ongoing Search for Biomarkers
rnero Élez Microsatellite instability (MSI) is a biological condition associated with inflamed tumors, high tumor mutational burden (TMB), and responses to immune checkpoint inhibitors. In colorectal cancer (CRC), MSI tumors are found in 5% of patients in the metastatic setting and 15% in early-stage disease. Following the impressive clinical activity of immune checkpoint inhibitors in the metastatic setting, associated with deep and long-lasting responses, the development of immune checkpoint inhibitors has expanded to early-stage disease. Several phase II trials have demonstrated a high rate of pathological compl...
Source: Cancers - August 24, 2023 Category: Cancer & Oncology Authors: Ros Baraibar Saoudi Rodriguez Salv à Tabernero Élez Tags: Review Source Type: research

Immune Checkpoint Inhibitors in Triple Negative Breast Cancer: The Search for the Optimal Biomarker
Biomark Insights. 2022 Feb 22;17:11772719221078774. doi: 10.1177/11772719221078774. eCollection 2022.ABSTRACTTriple negative breast cancer (TNBC) is a high-risk and aggressive malignancy characterized by the absence of estrogen receptors (ER) and progesterone receptors (PR) on the surface of malignant cells, and by the lack of overexpression of human epidermal growth factor 2 (HER2). It has limited therapeutic options compared to other subtypes of breast cancer. There is now a growing body of evidence on the role of immunotherapy in TNBC, however much of the data from clinical trials is conflicting and thus, challenging fo...
Source: Biomarker Insights - February 28, 2022 Category: General Medicine Authors: Sadaf Qureshi Nancy Chan Mridula George Shridar Ganesan Deborah Toppmeyer Coral Omene Source Type: research

Airway Diseases Education and Expertise (ADEX ) in Pediatrics: Adaptation for Clinical Practice in India.
Abstract JUSTIFICATION: Asthma and allergic rhinitis together are part of the concept of one airway, one disease or united airway disease. The management of allergic airway diseases should address this united concept and manage the issue by educating the patients and their parents and health care providers, along with environmental control measures, pharmacotherapy and immunotherapy. Here, we present recommendations from the module of Airway Diseases Education and Expertise (ADEX) that focused on allergic rhinitis, asthma and sleep disorder breathing as a single entity or Allergic Airway Disease. PROCESS: A w...
Source: Indian Pediatrics - February 8, 2016 Category: Pediatrics Authors: Paramesh H, Nagaraju K, Sukumaran TU, Agarkhedkar S, Bhakta S, Tilak R, Vijayasekaran D, Narayanan V, Mane A, Phansalkar A, Kadhe G Tags: Indian Pediatr Source Type: research

Patient education programme on immunotherapy in multiple sclerosis (PEPIMS): A controlled rater-blinded study.
CONCLUSION: Delivering evidence-based information on multiple sclerosis disease modifying therapies within a rehabilitation setting led to a marked increase of informed choices. PMID: 27072153 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - April 11, 2016 Category: Rehabilitation Authors: Köpke S, Kasper J, Flachenecker P, Meißner H, Brandt A, Hauptmann B, Bender G, Backhus I, Rahn AC, Pöttgen J, Vettorazzi E, Heesen C Tags: Clin Rehabil Source Type: research

Treatment of older patients with acute lymphoblastic leukemia.
Authors: Gökbuget N Abstract The treatment of older patients with acute lymphoblastic leukemia (ALL) is an unmet medical need. With increasing age, ALL patients have a significantly lower clinical remission rate, higher early mortality, higher relapse rate, and poorer survival compared with younger patients. This is only partly explained by a higher incidence of poor prognostic factors in the older age group. Most importantly, intensive chemotherapy with or without stem cell transplantation (SCT) is less well tolerated in older patients. Some progress has been made with delivering age-adapted, moderately intensive...
Source: Hematology ASH Education Program - December 4, 2016 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Emerging Subspecialties in Neurology: Headache medicine
We describe the history of the headache field, recent advances, and information about training and working in the headache field.
Source: Neurology - March 27, 2017 Category: Neurology Authors: Begasse de Dhaem, O., Minen, M. T. Tags: All Headache, Migraine, All Education RESIDENT AND FELLOW SECTION Source Type: research