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Procedure: Liver Transplant

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Comprehensive Care of Patients with Chronic Liver Disease.
Abstract Chronic liver disease results from a wide range of conditions, for which individual management is beyond the scope of this article. General education, counseling, and harm reduction practices are important to the primary care of these patients, as are monitoring for cirrhosis and management of its complications. For patients with advanced liver disease, comprehensive care includes considering referral for liver transplantation, educating and empowering patients to prioritize goals of care, and optimizing symptom relief. PMID: 26320039 [PubMed - in process]
Source: The Medical Clinics of North America - September 1, 2015 Category: Journals (General) Authors: James J, Liou IW Tags: Med Clin North Am Source Type: research

The experiences, motivations, and opinions of New Zealand's live liver donors.
CONCLUSION: This unique and informed group have experienced both what it means to have a loved one waiting for a transplant and how it feels to be an organ donor. If New Zealand is serious about wanting to increase deceased organ donation rates, we should consider the experiences such as those who have undergone live donation. PMID: 26905987 [PubMed - in process]
Source: New Zealand Medical Journal - February 26, 2016 Category: Journals (General) Tags: N Z Med J Source Type: research

Hepatotoxicity of paracetamol and related fatalities.
Authors: Tittarelli R, Pellegrini M, Scarpellini MG, Marinelli E, Bruti V, di Luca NM, Busardò FP, Zaami S Abstract Paracetamol, also known as acetaminophen, is the most commonly used antipyretic and pain reliever and since 1955 it is available over-the-counter as a single formulation or in combination with other substances and, as indicated by the World Health Organization, it can be used in all the three steps of pain intensity. Paracetamol toxicity is one of the most common causes of poisoning worldwide. While paracetamol is described as relatively nontoxic when administered in therapeutic doses, it is known to...
Source: European Review for Medical and Pharmacological Sciences - April 7, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Management of liver complications in sickle cell disease.
Authors: Suddle AR Abstract Liver disease is an important cause of morbidity and mortality in patients with sickle cell disease (SCD). Despite this, the natural history of liver disease is not well characterized and the evidence basis for specific therapeutic intervention is not robust. The spectrum of clinical liver disease encountered includes asymptomatic abnormalities of liver function; acute deteriorations in liver function, sometimes with a dramatic clinical phenotype; and decompensated chronic liver disease. In this paper, the pathophysiology and clinical presentation of patients with acute and chronic liver...
Source: Hematology ASH Education Program - December 7, 2019 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

Updates on the diagnosis and management of the most common hereditary porphyrias: AIP and EPP.
Authors: Linenberger M, Fertrin KY Abstract The porphyrias are a family of metabolic disorders caused by defects in the activity of one of the enzymes in the heme biosynthetic pathway. Acute intermittent porphyria (AIP), caused by autosomal dominant mutations in the gene encoding hydroxymethylbilane synthase, can lead to hepatocyte overaccumulation and systemic distribution of the proximal porphyrin precursors, 5-aminolevulinic acid (ALA) and porphobilinogen (PBG). ALA and PBG are toxic to neurons and extrahepatic tissue and cause the neurovisceral clinical manifestations of AIP. Management of AIP includes awarenes...
Source: Hematology ASH Education Program - December 5, 2020 Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research

What Problems are Ciliopathies Associated With?
Discussion Nephronophthisis (NPHP) one cause of end-stage renal disease (ESRD) usually occurring before age 30 years. NPHP is a non-motile ciliopathy affecting cellular sensing in the renal tubular epithelium. See To Learn More below. The incidence varies according to location with 1:1 million in the US but 1:50,000 in Finland. There are 3 subtypes: Infantile Occurs usually within 1 year of life Enlarged kidneys and severe hypertension In utero can have oligohydramnios problems such as pulmonary hypoplasia, facial dysmorphisms, limb contractures Extra-renal problems include congenital heart disease, liver fibrosis, recur...
Source: PediatricEducation.org - July 5, 2021 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What are Presentations of Neuroblastoma?
Discussion Abdominal pain is a very common problem with abdominal masses being somewhat less common. If one considers how frequently patients have abdominal pain due to constipation and that it often presents with a fecal mass, both of these are commonplace. Abdominal and pelvic organs are sometimes mistaken for masses also. As the abdominal and pelvic cavities are large, tumors often need to be quite large before they cause functional problems and/or can be palpated on physical examination. A review of abdominal masses can be found here. A review of recurrent abdominal pain can be found here. A review of acute abdominal p...
Source: PediatricEducation.org - March 27, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

What Are Underlying Risk Factors for Liver Abscesses?
This study specific excluded patients with ALA or candidemia. LA treatment is usually antibiotics and less invasive surgical techniques such as aspiration or percutaneous catheter drainage, but other treatment including resection is sometimes needed Overall mortality from LA has decreased from 15-40% to as low as 0.8% in the pediatric populations as noted above. Learning Point LA can occur solely because of exposure to infectious organisms but is also commonly associated with hepatobiliary pathology as well. In Northern India study, the “[m]ajority of …children had no predisposing factors for development of LA ...
Source: PediatricEducation.org - August 21, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Authors: Krawczyk M, Lammert F Abstract Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research t...
Source: Annals of Hepatology - October 24, 2017 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

The search for noninvasive methods to identify liver fibrosis in children with nonalcoholic fatty liver disease.
Authors: Mandelia C, Kabbany MN, Conjeevaram Selvakumar PK, Alkhouri N Abstract Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity epidemic. Recent studies have clearly shown that the stage of fibrosis in adults with NAFLD is the most important histological feature in long-term outcomes and the development of liver-related complications. Despite the paucity of data regarding the natural history of pediatric NAFLD, its progression to cirrhosis and end-stage liver disease requiring liver transplantation is well documented. Given the high prevalence of NAFLD in children and adults, th...
Source: Future Medicine: Biomarkers in Medicine - March 10, 2018 Category: Internal Medicine Tags: Biomark Med Source Type: research

Search for Genetic Modifiers of PSC: Time to Increase the Number of Needles in the Haystack.
Authors: Krawczyk M, Lammert F Abstract Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research t...
Source: Annals of Hepatology - June 9, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Contribution of Turkey in Liver Transplant Research: A Scopus Database Search
CONCLUSIONS: Among countries, Turkey had the most living donor liver transplants in 2019 and could serve as a model to European countries for donor shortages. Although the United States performs 5 times more liver transplants than Turkey, their publications rate was almost 22 times more. Combining a workload of performing research and publishing along with transplant surgery is together hard to master. Although Turkey has valuable experiences and has opened frontiers in transplantation, publications need to keep up with their hard work and innovations.PMID:35607793 | DOI:10.6002/ect.2021.0491
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 24, 2022 Category: Transplant Surgery Authors: Oru ç Numan Gökçe Sevil Alkan Source Type: research