Filtered By:
Specialty: Biology
This page shows you your search results in order of relevance. This is page number 9.
Order by Relevance | Date
Total 84794 results found since Jan 2013.
Mitosis: Kinetochores determined against random search-and-capture
Curr Biol. 2022 Mar 14;32(5):R231-R234. doi: 10.1016/j.cub.2022.02.003.ABSTRACTThe mechanism of chromosome biorientation during mitotic spindle assembly remains a century-old mystery. In contrast to the stochastic models that have dominated the field for decades, a new study now proposes that chromosome biorientation is instead deterministic and driven by microtubule self-organization at kinetochores.PMID:35290774 | DOI:10.1016/j.cub.2022.02.003
Source: Current Biology - March 15, 2022 Category: Biology Authors: Joana Soares-de-Oliveira Helder Maiato Source Type: research
CellDynaMo –stochastic reaction-diffusion-dynamics model: Application to search-and-capture process of mitotic spindle assembly
by Evgenii Kliuchnikov, Artem Zhmurov, Kenneth A. Marx, Alex Mogilner, Valeri Barsegov
We introduce a Stochastic Reaction-Diffusion-Dynamics Model (SRDDM) for simulations of cellular mechanochemical processes with high spatial and temporal resolution. The SRDDM model is mapped into the CellDynaMo package, which couples the spatially inhomogeneous reaction-diffusion master equation t o account for biochemical reactions and molecular transport within the Langevin Dynamics (LD) framework to describe dynamic mechanical processes. This computational infrastructure allows the simulation of hours of molecular machine dynamics in...
Source: PLoS Computational Biology - June 3, 2022 Category: Biology Authors: Evgenii Kliuchnikov Source Type: research
Search for New Target Genes of MicroRNA for Differential Diagnosis of Benign and Malignant Neoplasms of the Thyroid Gland by In Silico Methods
In this study,in silico methods were used to search for potential markers that are microRNA target genes. A list of 19 microRNAs was compiled, the expression of which varies depending on the type of thyroid neoplasms. For these microRNAs, the target genes were selected considering tissue specificity and association with thyroid diseases. We selected 9 target genes (MCM2,RASSF2,SPAG9,SSTR2,TP53BP1,INPP4B,CCDC80,GNAS, andPLK1), which can be considered as promising markers according to published data. Also, 6 new potential markers (CDK4,FGFR1,ERBB3,EGR1,MYLK, andSRC) were found, which make it possible to distinguish between f...
Source: Bulletin of Experimental Biology and Medicine - June 23, 2022 Category: Biology Source Type: research
Chromosome and protein folding: In search for unified principles
Curr Opin Struct Biol. 2023 Jun 14;81:102610. doi: 10.1016/j.sbi.2023.102610. Online ahead of print.ABSTRACTStructural biology has traditionally focused on the structures of proteins, short nucleic acids, small molecules, and their complexes. However, it is now widely recognized that the 3D organization of chromosomes should also be included in this list, despite significant differences in scale and complexity of organization. Here we highlight some notable similarities between the folding processes that shape proteins and chromosomes. Both biomolecules are folded by two types of processes: the affinity-mediated interactio...
Source: Current Opinion in Structural Biology - June 16, 2023 Category: Biology Authors: Leonid A Mirny Source Type: research
The Search for Single-Domain Antibodies Interacting with the Receptor-Binding Domain of SARS-CoV-2 Surface Protein
We performed a search for nanoantibodies that specifically interact with the receptor-binding domain (RBD) of the SARS-CoV-2 surface protein. The specificity of single-domain antibodies from the blood sera of a llama immunized with RBD of SARS-CoV-2 surface protein S (variant B.1.1.7 (Alpha)) was analyzed by ELISA. Recombinant trimers of the SARS-CoV-2 spike protein were used as antigens. In this work, a set of single-domain antibodies was obtained that specifically bind to the RBD of the SARS-CoV-2 virus.
Source: Bulletin of Experimental Biology and Medicine - July 19, 2023 Category: Biology Source Type: research
Neural network models for influenza forecasting with associated uncertainty using Web search activity trends
by Michael Morris, Peter Hayes, Ingemar J. Cox, Vasileios Lampos
Influenza affects millions of people every year. It causes a considerable amount of medical visits and hospitalisations as well as hundreds of thousands of deaths. Forecasting influenza prevalence with good accuracy can significantly help public health agencies to timely react to seasonal or novel strain epidemics. Although significant progress has been made, influenza forecasting remains a challenging modelling task. In this paper, we propose a methodological framework that improves over the state-of-the-art forecasting accuracy of influenza-like illness (I...
Source: PLoS Computational Biology - August 28, 2023 Category: Biology Authors: Michael Morris Source Type: research
The Automated Systematic Search Deduplicator (ASySD): a rapid, open-source, interoperable tool to remove duplicate citations in biomedical systematic reviews
Researchers performing high-quality systematic reviews search across multiple databases to identify relevant evidence. However, the same publication is often retrieved from several databases. Identifying and r...
Source: BMC Biology - September 7, 2023 Category: Biology Authors: Kaitlyn Hair, Zsanett Bahor, Malcolm Macleod, Jing Liao and Emily S. Sena Tags: Methodology article Source Type: research
Metabolism of hydrogen sulfide (H2S) and Production of Reactive Sulfur Species (RSS) by superoxide dismutase
Publication date: May 2018 Source:Redox Biology, Volume 15 Author(s): Kenneth R. Olson, Yan Gao, Faihaan Arif, Kanika Arora, Shivali Patel, Eric. R. DeLeon, Thomas R. Sutton, Martin Feelisch, Miriam M. Cortese-Krott, Karl D. Straub Reactive sulfur species (RSS) such as H2S, HS•, H2Sn, (n = 2–7) and HS2 •- are chemically similar to H2O and the reactive oxygen species (ROS) HO•, H2O2, O2 •- and act on common biological effectors. RSS were present in evolution long before ROS, and because both are metabolized by catalase it has been suggested that “antioxidant” enzymes originally evolved to regulate RSS and may...
Source: Redox Biology - December 6, 2017 Category: Biology Source Type: research
Catalase as a sulfide-sulfur oxido-reductase: An ancient (and modern?) regulator of reactive sulfur species (RSS)
Publication date: August 2017 Source:Redox Biology, Volume 12 Author(s): Kenneth R. Olson, Yan Gao, Eric R. DeLeon, Maaz Arif, Faihaan Arif, Nitin Arora, Karl D. Straub Catalase is well-known as an antioxidant dismutating H2O2 to O2 and H2O. However, catalases evolved when metabolism was largely sulfur-based, long before O2 and reactive oxygen species (ROS) became abundant, suggesting catalase metabolizes reactive sulfide species (RSS). Here we examine catalase metabolism of H2Sn, the sulfur analog of H2O2, hydrogen sulfide (H2S) and other sulfur-bearing molecules using H2S-specific amperometric electrodes and fluorophore...
Source: Redox Biology - March 9, 2017 Category: Biology Source Type: research
Preparatory attention incorporates contextual expectations
Curr Biol. 2021 Dec 9:S0960-9822(21)01648-1. doi: 10.1016/j.cub.2021.11.062. Online ahead of print.ABSTRACTHumans are remarkably proficient at finding objects within complex visual scenes. According to current theories of attention,1-3 visual processing of an object of interest is favored through the preparatory activation of object-specific representations in visual cortex.4-15 One key problem that is inherent to real-world visual search but is not accounted for by current theories is that a given object will produce a dramatically different retinal image depending on its location, which is unknown in advance. For instanc...
Source: Current Biology - December 17, 2021 Category: Biology Authors: Surya Gayet Marius V Peelen Source Type: research
The Application of Silver to Decontaminate Dental Unit Waterlines-a Systematic Review
Biol Trace Elem Res. 2022 Jan 8:1-15. doi: 10.1007/s12011-022-03105-w. Online ahead of print.ABSTRACTThe contamination of dental unit waterlines (DUWLs) is a major health concern since it can pose cross-infection risks among dental professionals and their patients. Silver is one of the widely used metals in medical fields due to its superior antimicrobial properties. Silver-based agents have been commercially available for the decontamination of dental unit water currently. This systematic review aims to examine the evidence supporting efficacy and safety of application of silver to decontaminate DUWLs. We performed a sear...
Source: Biological Trace Element Research - January 8, 2022 Category: Biology Authors: Feiruo Hong Piaopiao Chen Xuefen Yu Qianming Chen Source Type: research
Drosophila re-zero their path integrator at the center of a fictive food patch
Curr Biol. 2021 Aug 21:S0960-9822(21)01108-8. doi: 10.1016/j.cub.2021.08.006. Online ahead of print.ABSTRACTThe ability to keep track of one's location in space is a critical behavior for animals navigating to and from a salient location, and its computational basis is now beginning to be unraveled. Here, we tracked flies in a ring-shaped channel as they executed bouts of search triggered by optogenetic activation of sugar receptors. Unlike experiments in open field arenas, which produce highly tortuous search trajectories, our geometrically constrained paradigm enabled us to monitor flies' decisions to move toward or away...
Source: Current Biology - August 27, 2021 Category: Biology Authors: Amir H Behbahani Emily H Palmer Rom án A Corfas Michael H Dickinson Source Type: research
