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Specialty: Epidemiology

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Total 51 results found since Jan 2013.

PSMD9 expression predicts radiotherapy response in breast cancer
Conclusions: We conclude that PSMD9 expression may predict radiotherapy benefit, with low expression indicative of relative radio-sensitivity, the opposite of previous reports relating to 26S proteasome expression. Our conclusion is compatible with use of proteasome inhibitors as radio-sensitizers, and highlights PSMD9 as a potential target for radio-sensitizing drugs.
Source: Epidemiologic Perspectives and Innovations - March 28, 2014 Category: Epidemiology Authors: Fiona E LanglandsDavid DodwellAndrew M HanbyKieran HorganRebecca A Millican-SlaterValerie SpeirsEldo T VergheseLaura SmithThomas A Hughes Source Type: research

Suppression of VEGF by Reversible-PEGylated Histidylated Polylysine in Cancer Therapy.
Abstract A reversible-PEGylated polylysine is designed and developed for efficient delivery of siRNA. In this unique structure, the ε-amino groups of disulfide linked poly(ethylene glycol) (PEG) and polylysine (mPEG-SS-PLL) are partially replaced by histidine groups, in order to develop the histidylated reversible-PEGylated polylysine (mPEG-SS-PLH), for enhanced endosome escape ability. The transfection efficacy of mPEG-SS-PLH is found to closely correlate with histidine substitution. Its maximum transfection efficiencies are determined, respectively, to be 75%, 42%, and 24%, against 293T, MCF-7, and PC-3 cells. ...
Source: Adv Data - May 7, 2014 Category: Epidemiology Authors: Cai X, Zhu H, Dong H, Li Y, Su J, Shi D Tags: Adv Healthc Mater Source Type: research

Repression of phosphoinositide-dependent protein kinase 1 expression by ciglitazone via Egr-1 represents a new approach for inhibition of lung cancer cell growth
Conclusion: Collectively, our results demonstrate that ciglitazone inhibits PDK1 expression through AMPKalpha-mediated induction of Egr-1 and Egr-1 binding to the specific DNA site in the PDK1 gene promoter, which is independent of PPARgamma. Activation of AMPKalpha by metformin enhances the effect of ciglitazone. In turn, this leads to inhibition of NSCLC cell proliferation.
Source: Epidemiologic Perspectives and Innovations - June 13, 2014 Category: Epidemiology Authors: SWei Sunny HannQing TangFang ZhengShunyu ZhaoJianping ChenZhiYu Wang Source Type: research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
Conclusions: These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK/Pyk2 signaling pathways. This provides evidence that melatonin may be a potential therapeutic molecule targeting the hypoxic microenvironment of glioma.
Source: Epidemiologic Perspectives and Innovations - March 20, 2015 Category: Epidemiology Authors: Cheng-Shi XuZe-Fen WangXiao-Dong HuangLi-Ming DaiChang-Jun CaoZhi-Qiang Li Source Type: research

Uterine NDRG2 expression is increased at implantation sites during early pregnancy in mice, and its down-regulation inhibits decidualization of mouse endometrial stromal cells
Conclusions: These results suggest that NDRG2 might play an important role in the process of decidualization during early pregnancy.
Source: Epidemiologic Perspectives and Innovations - May 26, 2015 Category: Epidemiology Authors: Yan GuXuan ZhangQian YangJian-mei WangYa-ping HeZhao-gui SunHui-qin ZhangJian Wang Source Type: research

Uncovering Tumor-Promoting Roles of Activin A in Pancreatic Ductal Adenocarcinoma
Adv Sci (Weinh). 2023 Apr 21:e2207010. doi: 10.1002/advs.202207010. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with high incidence rates of metastasis and cachexia. High circulating activin A, a homodimer of inhibin βA subunits that are encoded by INHBA gene, predicts poor survival among PDAC patients. However, it still raises the question of whether activin A suppression renders favorable PDAC outcomes. Here, the authors demonstrate that activin A is abundantly detected in tumor and stromal cells on PDAC tissue microarray and mouse PDAC sections. In orthotopic ...
Source: Adv Data - April 21, 2023 Category: Epidemiology Authors: Seok-Yeong Yu Yi Luan Siyuan Tang Amirhossein Abazarikia Rosemary Dong Thomas C Caffrey Michael A Hollingsworth David Oupicky So-Youn Kim Source Type: research

The novel IGF-IR/Akt-dependent anticancer activities of glucosamine
Conclusions: Taken together, our results suggest that targeting the IGF-1R/Akt pathway with glucosamine may be an effective therapeutic strategy for treating some type of cancer.
Source: Epidemiologic Perspectives and Innovations - January 20, 2014 Category: Epidemiology Authors: Ki-Hoon SongJu-Hee KangJong-Kyu WooJeong-Seok NamHye-Young MinHo-Young LeeSoo-Youl KimSeung-Hyun Oh Source Type: research

TGFbetaR2 is a major target of miR-93 in nasopharyngeal carcinoma aggressiveness
Conclusion: The present study reports an involvement of miR-93-mediated TGFbetaR2 down-regulation in NPC aggressiveness, thus giving extended insights into molecular mechanisms underlying cancer aggressiveness. Approaches aimed at blocking miR-93 may serve as a promising therapeutic strategy for treating NPC patients.
Source: Epidemiologic Perspectives and Innovations - March 8, 2014 Category: Epidemiology Authors: Xiaoming LyuWeiyi FangHang ZhengLongmei CaiYanfen YeLan ZhangJinbang liHong PengWilliam C ChoEna WangFrancesco M MarincolaKaitai YaoHongbing CaiJiliang LiXin Li Source Type: research

A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages
Conclusions: We have successfully developed an automated HCI assay to quantitate MNGCs induced by Bp in macrophages. This assay was then used to characterize the phenotype of the Bp mutants for their ability to induce MNGC formation and identify small molecules that interfere with this process. Successful application of chemical genetics and functional reverse genetics siRNA approaches in the MNGC assay will help gain a better understanding of the molecular targets and cellular mechanisms responsible for the MNGC phenotype induced by Bp, by other bacteria such as Mycobacterium tuberculosis, or by exogenously added cytokines.
Source: Epidemiologic Perspectives and Innovations - April 22, 2014 Category: Epidemiology Authors: Gianluca PegoraroBrett P EatonRicky L UlrichDouglas J LaneJenifer F OjedaSina BavariDavid DeShazerRekha G Panchal Source Type: research

p38alpha MAPK-mediated induction and interaction of FOXO3a and p53 contribute to the inhibited-growth and induced-apoptosis of human lung adenocarcinoma cells by berberine
Conclusion: Our results show that BBR inhibits proliferation and induces apoptosis of NSCLC cells through activation of p38alpha MAPK signaling pathway, followed by induction of the protein expression of p53 and FOXO3a. The latter contribute to the BBR-increased p21 (CIP1/WAF1) protein expression. The exogenous FOXO3a, interaction and mutually exclusive events of p53 and FOXO3a augment the overall response of BBR.
Source: Epidemiologic Perspectives and Innovations - April 26, 2014 Category: Epidemiology Authors: Fang ZhengQin TangJingJing WuShunYu ZhaoZhanYang LiangLiuning LiWanYin WuSwei Hann Source Type: research

Ganglioside GD2 in reception and transduction of cell death signal in tumor cells
Conclusions: Results of this study demonstrate that anti-GD2 antibodies not only passively bind to the surface of tumor cells but also directly induce rapid cell death after the incubation with GD2-positive tumor cells. These results suggest a new role of GD2 as a receptor that actively transduces death signal in malignant cells.
Source: Epidemiologic Perspectives and Innovations - April 28, 2014 Category: Epidemiology Authors: Igor I DoroninPolina A VishnyakovaIrina V KholodenkoEugene D PonomarevDmitry Y RyazantsevIrina M MolotkovskayaRoman V Kholodenko Source Type: research

HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A
Conclusion: It is concluded that non-response to everolimus is characterized by increased cdk2/cyclin A, driving RCC cells into the G2/M-phase. VPA hinders everolimus non-response by diminishing cdk2/cyclin A. Therefore, treatment with HDAC-inhibitors might be an option for patients with advanced renal cell carcinoma and acquired everolimus resistance.
Source: Epidemiologic Perspectives and Innovations - June 16, 2014 Category: Epidemiology Authors: Eva JuengelSnigdha NowazJasmina Makarevi¿Iyad NatshehIsabella WernerKaren NelsonMichael ReiterIgor TsaurJens ManiSebastian HarderGeorg BartschAxel HaferkampRoman A Blaheta Source Type: research

The role of A-kinase anchoring protein 95-like protein in annealing of tRNALys3 to HIV-1 RNA
Conclusion: The results support a hypothesis that HAP95 may transiently block RHA's activity to protect the annealed tRNALys3 on viral RNA in the cells from removing by RHA during the packaging of RHA into virus particles, thus facilitating the annealing of tRNALys3 to HIV-1 RNA.
Source: Epidemiologic Perspectives and Innovations - July 17, 2014 Category: Epidemiology Authors: Li XingXia ZhaoFei GuoLawrence Kleiman Source Type: research

TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis
Conclusions: BDNF/TrkB signaling plays an important role in the NRG1-stimulated NR2B regulation. These findings could be of relevance to many neurodevelopmental disorders, as NRG1 and BDNF signaling pathways have been implicated in autism and schizophrenia.
Source: Epidemiologic Perspectives and Innovations - July 24, 2014 Category: Epidemiology Authors: Chirayu C PandyaAnilkumar PILLAI Source Type: research

Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma
Conclusions: Pioglitazone inhibits VSMCs proliferation and promotes apoptosis of VSMCs through a PPARgamma signaling pathway. Up-regulation of caspase 3 and down-regulation of cyclins mediates pioglitazone's anti-proliferative and pro-apoptotic effects. Our results imply that pioglitazone prevents the VSMCs proliferation via modulation of caspase and cyclin signaling pathways in a PPARgamma-dependent manner.
Source: Epidemiologic Perspectives and Innovations - September 19, 2014 Category: Epidemiology Authors: Jing WanZhichao XiaoShengping ChaoShixi XiongXuedong GanXuguang QiuChang XuYexin MaXin Tu Source Type: research