Pioglitazone modulates the proliferation and apoptosis of vascular smooth muscle cells via peroxisome proliferators-activated receptor-gamma

Conclusions: Pioglitazone inhibits VSMCs proliferation and promotes apoptosis of VSMCs through a PPARgamma signaling pathway. Up-regulation of caspase 3 and down-regulation of cyclins mediates pioglitazone's anti-proliferative and pro-apoptotic effects. Our results imply that pioglitazone prevents the VSMCs proliferation via modulation of caspase and cyclin signaling pathways in a PPARgamma-dependent manner.
Source: Epidemiologic Perspectives and Innovations - Category: Epidemiology Authors: Source Type: research