PSMD9 expression predicts radiotherapy response in breast cancer

Conclusions:
We conclude that PSMD9 expression may predict radiotherapy benefit, with low expression indicative of relative radio-sensitivity, the opposite of previous reports relating to 26S proteasome expression. Our conclusion is compatible with use of proteasome inhibitors as radio-sensitizers, and highlights PSMD9 as a potential target for radio-sensitizing drugs.

Source: Epidemiologic Perspectives and Innovations - March 28, 2014 Category: Epidemiology Authors: Fiona E LanglandsDavid DodwellAndrew M HanbyKieran HorganRebecca A Millican-SlaterValerie SpeirsEldo T VergheseLaura SmithThomas A Hughes Source Type: research