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Total 101 results found since Jan 2013.

Glucagon‐like peptide‐1 (GLP‐1) preserves non‐alcoholic fatty liver disease (NAFLD) through inhibition of the endoplasmic reticulum (ER) stress‐associated pathway
ConclusionGLP‐1 protected against non‐alcoholic fatty liver disease by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46. This article is protected by copyright. All rights reserved.
Source: Hepatology Research - July 4, 2015 Category: Internal Medicine Authors: Na. Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research

Glucagon‐like peptide‐1 preserves non‐alcoholic fatty liver disease through inhibition of the endoplasmic reticulum stress‐associated pathway
ConclusionGLP‐1 protected against NAFLD by inactivating the ER stress‐associated apoptosis pathway. In addition, the effect was possibly related to the signaling pathway of ERp46.
Source: Hepatology Research - August 18, 2015 Category: Internal Medicine Authors: Na Ao, Jing Yang, Xiaochen Wang, Jian Du Tags: Original Article Source Type: research

In vitro effect of microRNA-107 targeting Dkk-1 by regulation of Wnt/β-catenin signaling pathway in osteosarcoma
Conclusion: We conclude that miR-107 is likely to inhibit the occurrence and development of OS by down-regulating Dkk-1 via the Wnt/β-catenin signaling pathway, providing us with a new therapeutic target for the treatment of OS.
Source: Medicine - July 1, 2017 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Tongxinluo attenuates oxygen-glucose-serum deprivation/restoration-induced endothelial barrier breakdown via peroxisome proliferator activated receptor-α/angiopoietin-like 4 pathway in high glucose-incubated human cardiac microvascular endothelial cells
Conclusion: These data suggest cell-intrinsic and endothelial-specific Angptl4 mediates the protection of TXL against endothelial barrier breakdown during oxygen-glucose-serum deprivation and restoration under high glucose condition partly via the PPAR-α/Angptl4 pathway.
Source: Medicine - August 21, 2020 Category: Internal Medicine Tags: Research Article: Clinical Trial/Experimental Study Source Type: research

Activation of the developmental pathway Neurogenin‐3/microRNA‐7a regulates cholangiocyte proliferation in response to injury
ABSTRACT Background/aims: The activation of the biliary stem‐cell signalling pathway Hes‐1/PDX‐1 in mature cholangiocytes determines cell proliferation. Neurogenin‐3 (Ngn‐3) is required for pancreas development and ductal cell neogenesis. PDX‐1‐dependent activation of Ngn‐3 initiates the differentiation program, by inducting microRNA (miR)‐7 expression. Here, we investigated the role Ngn‐3 on cholangiocyte proliferation. Methods: Expression levels of Ngn‐3 and miR‐7 isoforms were tested in cholangiocytes from normal and cholestatic human livers. Ngn‐3 was knocked‐down in vitro in normal rat chol...
Source: Hepatology - June 13, 2014 Category: Internal Medicine Authors: Marco Marzioni, Laura Agostinelli, Cinzia Candelaresi, Stefania Saccomanno, Samuele De Minicis, Luca Maroni, Eleonora Mingarelli, Chiara Rychlicki, Luciano Trozzi, Jesus M. Banales, Antonio Benedetti, Gianluca Svegliati Baroni Tags: Autoimmune, Cholestatic and Biliary Disease Source Type: research

Membrane Trafficking of Collecting Duct Water Channel Protein AQP2 Regulated by Akt/AS160.
In this study, we demonstrated that 1) small interfering RNA (siRNA)-mediated gene silencing of Akt1 significantly decreased Akt1 and phospho-AS160 protein expression; and 2) confocal laser scanning microscopy of AQP2 in mouse cortical collecting duct cells (M-1 cells) revealed AS160 knockdown by siRNA increased AQP2 expression in the plasma membrane compared with controls, despite the absence of dDAVP stimulation. Thus, the results suggest that PI3K/Akt pathways could play a role in AQP2 trafficking via the AS160 protein. PMID: 21468198 [PubMed]
Source: Electrolyte and Blood Pressure - December 11, 2015 Category: Internal Medicine Tags: Electrolyte Blood Press Source Type: research

Targeting polo-like kinase 1, a regulator of p53, in the treatment of adrenocortical carcinoma
Conclusions: These preclinical studies suggest that targeting p53 through PLK-1 is an attractive chemotherapy strategy warranting further investigation in adrenocortical cancer.
Source: Clinical and Translational Medicine - January 11, 2016 Category: Internal Medicine Authors: Kimberly BusseyAditi BapatClaire LinnehanMelissa WandoloskiErica DastrupErik RogersPaul GonzalesMichael Demeure Source Type: research

Hyperhomocysteinemia Activates the Aryl Hydrocarbon Receptor‐CD36 Pathway to Promote Hepatic Steatosis in Mice
In conclusion, our results strongly suggest that HHcy activated the AHR‐CD36 pathway by increasing hepatic LXA4 content, which resulted in hepatic steatosis. This article is protected by copyright. All rights reserved.
Source: Hepatology - February 29, 2016 Category: Internal Medicine Authors: Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Hyperhomocysteinemia activates the aryl hydrocarbon receptor/CD36 pathway to promote hepatic steatosis in mice
Conclusion: In conclusion, our results strongly suggest that HHcy activated the AHR‐CD36 pathway by increasing hepatic LXA4 content, which resulted in HS. (Hepatology 2016; 00:000–000)
Source: Hepatology - April 4, 2016 Category: Internal Medicine Authors: Liu Yao, Chunjiong Wang, Xu Zhang, Liyuan Peng, Wenli Liu, Xuejiao Zhang, Yajin Liu, Jinlong He, Changtao Jiang, Ding Ai, Yi Zhu Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons
Abstract: Tricyclic antidepressant amitriptyline (AM) has been shown to exert neurotrophic activity on neurons. We thus explored whether AM may aid the neuronal development and protect anesthesia-induced neuro-injury in young spinal cord dorsal root ganglion (DRG) neurons. The DRG explants were prepared from 1-day-old rats. The effect of AM on aiding DRG neural development was examined by immunohistochemistry at dose-dependent manner. AM-induced changes in gene and protein expressions, and also phosphorylation states of tyrosine kinases receptor A (TrkA) and B (TrkB) in DRG, were examined by quantitative real-time polymer...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysisof Observ Studiesin Epidemiology Source Type: research

SIRT3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity
Conclusion: our data identified SIRT3 to be a novel negative regulator of autophagy, whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. This article is protected by copyright. All rights reserved.
Source: Hepatology - April 24, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Sirtuin 3 acts as a negative regulator of autophagy dictating hepatocyte susceptibility to lipotoxicity
Conclusion: Our data indicate that SIRT3 is a negative regulator of autophagy whose activation by SFAs contributes to lipotoxicity in hepatocytes and suggest that restraining SIRT3 overactivation can be a potential therapeutic choice for the treatment of NAFLD as well as other metabolic disorders, with lipotoxicity being the principal pathomechanism. (Hepatology 2017).
Source: Hepatology - July 20, 2017 Category: Internal Medicine Authors: Songtao Li, Xiaobing Dou, Hua Ning, Qing Song, Wei Wei, Ximei Zhang, Chen Shen, Jiaxin Li, Changhao Sun, Zhenyuan Song Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research

Farnesoid X Receptor Signaling Activates the Hepatic X ‐box Binding Protein 1 Pathway in vitro and in Mice
Conclusion: FXR signaling activates the IRE1α/XBP1 pathway in vivo and in vitro. FXR pathway activation increases XBP1 splicing and enhances phosphorylated‐IRE1α expression. These effects are mediated, at least in part, by SHP. IRE1α/XBP1 pathway activation by bile acids and pharmacologic FXR agonists may be protective during liver injury and may have therapeutic implications for liver diseases. This article is protected by copyright. All rights reserved.
Source: Hepatology - January 30, 2018 Category: Internal Medicine Authors: Xiaoying Liu, Grace L. Guo, Bo Kong, David B. Hilburn, Susan C. Hubchak, Seong Park, Brian LeCuyer, Antony Hsieh, Li Wang, Deyu Fang, Richard M. Green Tags: Liver Biology and Pathobiology Source Type: research

β-Catenin expression is associated with cell invasiveness in pancreatic cancer.
Conclusions: Based on our data, β-catenin may be involved in cancer invasion in pancreatic cancer, and it is not associated with CD44, the invasion related protein. PMID: 30360026 [PubMed - as supplied by publisher]
Source: The Korean Journal of Internal Medicine - October 26, 2018 Category: Internal Medicine Authors: Nan JN, Kim OR, Lee MA Tags: Korean J Intern Med Source Type: research

Effect of mGluR7 on proliferation of human embryonic neural stem cells
This study is to investigate the effect of metabotropic glutamate receptor 7 (mGluR7) on the proliferation of human embryonic neural stem cells (NSCs) and its molecular mechanism. Human embryonic NSCs were isolated. The pCMV2-GV146-GFP-mGluR7 plasmid was transfected to over-express mGluR7 while mGluR7 siRNA was transfected to knockdown mGluR7. MTT assay was used to analyze cell proliferation. Flow cytometry was used to detect cell cycle and apoptosis. Protein and mRNA levels were analyzed by Western blot and RT-qPCR, respectively. The viability of human NSCs and the diameter of neurospheres after 24 hours, 48 hours, ...
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research