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Specialty: Endocrinology

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Total 648 results found since Jan 2013.

Fatty Acid-Binding Protein 4 mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy
Publication date: 15 August 2015 Source:Molecular and Cellular Endocrinology, Volume 411 Author(s): Fang Yao , Zhen Li , Takashi Ehara , Lin Yang , Dandan Wang , Lulu Feng , Yiming Zhang , Kun Wang , Yonghong Shi , Huijun Duan , Lianshan Zhang Type 2 diabetes is characterized by hyperglycemia and deregulated lipid metabolism with increased plasma non-esterified fatty acids (NEFA). Apoptosis of glomerular cells is a hallmark in diabetic glomerulosclerosis. Fatty acid-binding protein 4 (FABP4), a carrier protein for fatty acids, has been linked to diabetes and diabetic nephropathy (DN). Here we aimed to investigate the lin...
Source: Molecular and Cellular Endocrinology - June 26, 2015 Category: Endocrinology Source Type: research

Expression, regulation and function of Hmgn3 during decidualization in mice
Publication date: 15 September 2015 Source:Molecular and Cellular Endocrinology, Volume 413 Author(s): Dang-Dang Li, Chuan-Hui Guo, Liang Yue, Cui-Cui Duan, Zhan-Qing Yang, Hang Cao, Bin Guo, Zhan-Peng Yue Although Hmgn3 is involved in the regulation of development and cellular differentiation, its physiological roles on decidualization are still unknown. Here we showed that Hmgn3 was highly expressed in the decidua and decidualizing stromal cells. Overexpression of Hmgn3 variants, Hmgn3a or Hmgn3b, enhanced the expression of decidualization markers Prl8a2 and Prl3c1, whereas inhibition of Hmgn3 reduced their exp...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research

Rosiglitazone inhibition of calvaria-derived osteoblast differentiation is through both of PPARγ and GPR40 and GSK3β-dependent pathway
This study aims to investigate the effects of RSG on differentiation and mineralization of osteoblasts using primary cultured mouse fetal calvaria-derived osteoblasts as a model, and elucidate the receptor and signaling pathways responsible for these effects. We found that RSG suppressed the differentiation and mineralization of calvaria-derived osteoblasts. Peroxisome proliferators-activated receptor γ (PPARγ) siRNA significantly reversed the inhibitory effect of RSG on osteogenic differentiation. The expression of G protein-coupled receptor (GPR) 40 was suppressed during differentiation, but was increased by RSG treatm...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research

Apoptosis induction by combination of drugs or a conjugated molecule associating non-steroidal anti-inflammatory and nitric oxide donor effects in medullary thyroid cancer models: implication of the tumor suppressor p73
Conclusion Association of NO with NSAID exhibited amplified anti-tumoral effects on in vitro and in vivo MTC models by inducing p73-dependent apoptotic cell death.
Source: Thyroid Research - August 14, 2015 Category: Endocrinology Source Type: research

Type 2 Iodothyronine Deiodinase Activity is Required for Rapid Stimulation of PI3K by Thyroxine in Human Umbilical Vein Endothelial Cells.
Abstract Thyroid hormones (THs) exert a number of physiological effects on the cardiovascular system. Some of the nongenomic actions of 3,5,3`-triiodothyronine (T3) are achieved by cross-coupling of TH receptor (TR) to the phosphatidylinositol 3-kinase (PI3K)/protein kinase Akt (Akt) pathway. We observed that both T3 and thyroxine (T4) rapidly stimulated Akt phosphorylation and Ras-related C3 botulinum toxin substrate 1 (Rac1) activation, which resulted in cell migration, in a PI3K dependent manner in human umbilical vein endothelial cells (HUVECs). We identified the expression of type 2 iodothyronine deiodinase (...
Source: Endocrinology - August 18, 2015 Category: Endocrinology Authors: Aoki T, Tsunekawa K, Araki O, Ogiwara T, Nara M, Sumino H, Kimura T, Murakami M Tags: Endocrinology Source Type: research

Reversal of pathological features of Graves' Orbitopathy by activation of Forkhead transcription factors, FOXOs.
CONCLUSIONS: FOXOs play a crucial repressor role in the regulation of HAS2/HA production and adipogenesis in orbital PFs. Our data reveals for the first time that resetting GO-associated pathological features through drug targeted activation of FOXOs could provide a feasible non-immunosuppressive therapeutic strategy for GO. PMID: 26502358 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - October 26, 2015 Category: Endocrinology Authors: Zhang L, Ji QH, Ruge F, Lane C, Morris D, Tee AR, Dayan CM, Ludgate M Tags: J Clin Endocrinol Metab Source Type: research

Epidermal Growth Factor: Porcine Uterine Luminal Epithelial Cell Migratory Signal during the Peri-implantation Period of Pregnancy
Publication date: Available online 24 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Wooyoung Jeong, Seoungo Jung, Fuller W. Bazer, Gwonhwa Song, Jinyoung Kim The majority of early conceptus mortality in pregnancy occurs during the peri-implantation period, suggesting that this period is important for conceptus viability and the establishment of pregnancy. Successful establishment of pregnancy in all mammalian species depends on the orchestrated molecular events that transpire at the conceptus-uterine interface during the peri-implantation period of pregnancy. This maternal-conceptus interactio...
Source: Molecular and Cellular Endocrinology - November 24, 2015 Category: Endocrinology Source Type: research

Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells
Publication date: Available online 27 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Sun-Mi Yun, Sang Hyeok Woo, Sang Taek Oh, Sung-Eun Hong, Tae-Boo Choe, Sang-Kyu Ye, Eun-Kyu Kim, Min Ki Seong, Hyun-A Kim, Woo Chul Noh, Jin Kyung Lee, Hyeon-Ok Jin, Yun-Han Lee, In-Chul Park Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Mela...
Source: Molecular and Cellular Endocrinology - November 27, 2015 Category: Endocrinology Source Type: research

The Cables1 gene in glucocorticoid regulation of pituitary corticotrope growth and Cushing disease.
CONCLUSIONS: CABLES1 is a critical regulator of corticotrope proliferation that defines a pathway often inactivated in CD and links proliferation to Gc resistance. PMID: 26695862 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - December 22, 2015 Category: Endocrinology Authors: Roussel-Gervais A, Couture C, Langlais D, Takayasu S, Balsalobre A, Rueda BR, Zukerberg LR, Figarella-Branger D, Brue T, Drouin J Tags: J Clin Endocrinol Metab Source Type: research

MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma
In conclusion, sustained activation of the MAPK and SHH pathways modulate the levels of DIO3 expression in PTC. Importantly, DIO3 silencing was associated with decreases in cell proliferation, thus suggesting a D3 role in tumor growth and aggressiveness.
Source: Endocrine-Related Cancer - January 29, 2016 Category: Endocrinology Authors: Romitti, M., Wajner, S. M., Ceolin, L., Ferreira, C. V., Ribeiro, R. V. P., Rohenkohl, H. C., Weber, S. d. S., Lopez, P. L. d. C., Fuziwara, C. S., Kimura, E. T., Maia, A. L. Tags: Research Source Type: research

Mir‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF‐1α signaling pathway
ConclusionThis study clarified the role of Mir‐217 in high glucose cultured RMCs through Sirt1/HIF‐1α signaling pathway and provided new therapeutic targets for diabetic nephropathy (DN).
Source: Diabetes/Metabolism Research and Reviews - February 1, 2016 Category: Endocrinology Authors: Ying Shao, Chuan Lv, Can Wu, Yuehong Zhou, Qiuyue Wang Tags: Research Article Source Type: research

Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
We report that chronic hyperglycemia weakens the endogenous antioxidant response, and the consequences of this defect are manifested by intracellular redox dysregulation, which can be restored by Keap1 inhibition. Targeted siRNA-based therapy represents a novel, efficacious strategy to reestablish redox homeostasis and accelerate diabetic cutaneous tissue regeneration.
Source: Diabetes - February 23, 2016 Category: Endocrinology Authors: Soares, M. A.; Cohen, O. D.; Low, Y. C.; Sartor, R. A.; Ellison, T.; Anil, U.; Anzai, L.; Chang, J. B.; Saadeh, P. B.; Rabbani, P. S.; Ceradini, D. J. Tags: Signal Transduction Source Type: research

Multiple Transduction Pathways Mediate Thyrotropin Receptor Signaling in Preosteoblast-Like Cells.
Abstract It has been shown that the thyroid stimulating hormone (TSH) receptor (TSHR) couples to a number of different signaling pathways although the Gs-cAMP pathway has been considered primary. Herein we measured the effects of TSH on bone marker mRNA and protein expression in preosteoblast-like U2OS cells stably expressing TSHRs. We determined which signaling cascades are involved in the regulation of interleukin 11 (IL11), osteopontin (OPN), and alkaline phosphatase (ALPL). We demonstrated that TSH-induced upregulation of IL11 is primarily mediated via the Gs pathway as IL11 was upregulated by forskolin (FSK),...
Source: Endocrinology - March 7, 2016 Category: Endocrinology Authors: Boutin A, Neumann S, Gershengorn MC Tags: Endocrinology Source Type: research

Maladaptative autophagy impairs adipose function in Congenital Generalized Lipodystrophy due to cavin-1 deficiency.
CONCLUSIONS: This study showed that cavin-1 deficiency resulted in maladaptative autophagy which contributed to insulin resistance and altered adipocyte differentiation. These new pathophysiological mechanisms could open new therapeutic perspectives for adipose tissue diseases including CGL4. PMID: 27144934 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - May 3, 2016 Category: Endocrinology Authors: Salle-Teyssières L, Auclair M, Terro F, Nemani M, Elsayed SM, Elsobky E, Lathrop M, Délépine M, Lascols O, Capeau J, Magré J, Vigouroux C Tags: J Clin Endocrinol Metab Source Type: research

Mir ‐217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF‐1α signaling pathway
ConclusionThis study clarified the role of Mir‐217 in high glucose cultured rat glomerular mesangial cells through Sirt1/HIF‐1α signaling pathway and provided new therapeutic targets for diabetic nephropathy. Copyright © 2016 John Wiley & Sons, Ltd.
Source: Diabetes/Metabolism Research and Reviews - April 20, 2016 Category: Endocrinology Authors: Ying Shao, Chuan Lv, Can Wu, Yuehong Zhou, Qiuyue Wang Tags: Research Article Source Type: research