MAPK and SHH pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma

In conclusion, sustained activation of the MAPK and SHH pathways modulate the levels of DIO3 expression in PTC. Importantly, DIO3 silencing was associated with decreases in cell proliferation, thus suggesting a D3 role in tumor growth and aggressiveness.

Source: Endocrine-Related Cancer - January 29, 2016 Category: Endocrinology Authors: Romitti, M., Wajner, S. M., Ceolin, L., Ferreira, C. V., Ribeiro, R. V. P., Rohenkohl, H. C., Weber, S. d. S., Lopez, P. L. d. C., Fuziwara, C. S., Kimura, E. T., Maia, A. L. Tags: Research Source Type: research