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Excessive expression of miR-1a by statin causes skeletal injury through targeting mitogen-activated protein kinase kinase kinase 1
CONCLUSION: Statin causes skeletal injury through induction of miR-1a excessive expression to decrease MAP3K1 gene expression.PMID:33864447 | DOI:10.18632/aging.202839
Source: Aging - April 17, 2021 Category: Biomedical Science Authors: Chang-Ning Fu Jia-Wen Song Zhi-Peng Song Qian-Wen Wang Wen-Wu Bai Tao Guo Peng Li Chao Liu Shuang-Xi Wang Bo Dong Source Type: research

Anti-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibody in necrotizing myopathy: treatment outcomes, cancer risk, and role of autoantibody level.
Conclusion: HMGCR Ab-positive NM patients are associated with statin exposure, have severe muscle weakness and high CK at presentation, lack other organ manifestations, and generally have favourable outcomes from immunosuppression. Anti-HMGCR Abs should be assessed in MSA-negative NM patients, particularly those with a history of statin exposure. PMID: 31801390 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - December 4, 2019 Category: Rheumatology Authors: Aggarwal R, Moghadam-Kia S, Lacomis D, Malik A, Qi Z, Koontz D, Burlingame RW, Oddis CV Tags: Scand J Rheumatol Source Type: research

Proton Pump Inhibitors: Risk for Myopathy?
CONCLUSION: A limited body of published data suggests that PPI use has been associated with myopathy-like symptoms without long-term effects following discontinuation. Although myopathy is a rare adverse effect observed with PPIs, it can be a serious side effect to be considered when starting a patient on acid suppression therapy. PMID: 27539734 [PubMed - as supplied by publisher]
Source: The Annals of Pharmacotherapy - August 17, 2016 Category: Drugs & Pharmacology Authors: Colmenares EW, Pappas AL Tags: Ann Pharmacother Source Type: research

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations
Abstract The incidence of myopathy increases dramatically in statin users who also exercise, likely limiting the positive impact of this lifesaving medication. New evidence also indicates that statin use can directly compromise aerobic exercise capacity; however, we are just beginning to understand the interactions of statins with exercise training and adaptations. This review focuses on the interactions of statins with aerobic exercise capacity and training adaptations to summarize the available information and draw attention to the gaps in our current knowledge in this area. PubMed, Web of knowledge, and Google...
Source: Sports Medicine - October 24, 2014 Category: Sports Medicine Source Type: research

No effect of combined coenzyme Q10 and selenium supplementation on atorvastatin-induced myopathy
Scandinavian Cardiovascular Journal, Volume 0, Issue 0, Page 1-8, Early Online.
Source: Scandinavian Cardiovascular Journal - January 11, 2013 Category: Cardiology Tags: article Source Type: research