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Total 180 results found since Jan 2013.

Epigenetic regulation of SIRT1-induced skeletal muscle mass: exercise and heart diseases.
This article is protected by copyright. All rights reserved. PMID: 28879684 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - September 6, 2017 Category: Physiology Authors: Fernandes T, Gomes JLP, Silveira AC Tags: J Physiol Source Type: research

Effects of leucine supplementation and resistance training on myopathy of diabetic rats
In conclusion, 5% leucine supplementation combined with resistance training has the potential to attenuate muscle loss and motor performance decrements in diabetic rats, at least in part through increased protein synthesis. Leucine and resistance training has the potential to attenuate muscle loss and motor performance decrements in diabetic rats.
Source: Physiological Reports - May 23, 2017 Category: Physiology Authors: Carlos Eduardo C. Martins, Vanessa B. de S. Lima, Brad J. Schoenfeld, Julio Tirapegui Tags: Original Research Source Type: research

Weak by the machines: muscle motor protein dysfunction – a side effect of intensive care unit treatment
Abstract Intensive care interventions involve periods of mechanical ventilation, sedation and complete mechanical silencing of patients. Critical illness myopathy (CIM) is an ICU‐acquired myopathy that is associated with limb muscle weakness, muscle atrophy, electrical silencing of muscle and motor proteinopathy. The hallmark of CIM is a preferential muscle myosin loss due to increased catabolic and reduced anabolic activity. The ubiquitin proteasome pathway plays an important role, apart from recently identified novel mechanisms affecting non‐lysosomal protein degradation or autophagy. CIM is not reproduced by pure di...
Source: Acta Physiologica - May 3, 2017 Category: Physiology Authors: O. Friedrich, S. Diermeier, L. Larsson Tags: Review Source Type: research

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in patients with mitochondrial myopathy
Muscle weakness and exercise intolerance negatively affect the quality of life of patients with mitochondrial myopathy. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated whether 1 wk of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in patients with mitochondrial myopathy. Ten patients with mitochondrial myopathy (40 ± 5 yr, maximal whole body oxygen uptake = 21.2 ± 3.2 ml·min–1·kg body wt&nda...
Source: AJP: Regulatory, Integrative and Comparative Physiology - May 1, 2017 Category: Physiology Authors: Nabben, M., Schmitz, J. P. J., Ciapaite, J., le Clercq, C. M. P., van Riel, N. A., Haak, H. R., Nicolay, K., de Coo, I. F. M., Smeets, H., Praet, S. F., van Loon, L. J., Prompers, J. J. Tags: Research Article Source Type: research

Weak by the Machines: Muscle Motor Protein Dysfunction ‐NDASH‐ a side Effect of Intensive Care Unit Treatment
This article is protected by copyright. All rights reserved.
Source: Acta Physiologica - April 1, 2017 Category: Physiology Authors: O Friedrich, S Diermeier, L Larsson Tags: Review Article Source Type: research

Skeletal muscle myopenia in mice model of bile duct ligation and carbon tetrachloride ‐induced liver cirrhosis
In conclusion, skeletal muscle myopenia was present in experimental models of BDL and CCl4‐induced cirrhosis. Moreover, reduction in protein synthesis and activation of protein degradation were the main mechanisms responsible for myopenia in BDL mice, while activation of ubiquitin‐pathway through inflammatory cytokines seems to be the main potential mechanism involved in CCl4 mice. The study elucidates the main morphological and functional alterations involved in skeletal muscle mass in experimental models of cirrhosis secondary to bile duct ligation (BDL) and CCl4 administration. A different molecular pathway seems t...
Source: Physiological Reports - March 31, 2017 Category: Physiology Authors: Michela Giusto, Laura Barberi, Francesca Di Sario, Emanuele Rizzuto, Carmine Nicoletti, Francesca Ascenzi, Anastasia Renzi, Nicola Caporaso, Giuseppe D'Argenio, Eugenio Gaudio, Antonio Musar ò, Manuela Merli Tags: Original Research Source Type: research

Optical probing of gastrocnemius in patients with peripheral artery disease characterizes myopathic biochemical alterations and correlates with stage of disease
This study characterizes the degree of myopathy as it relates to progression in Peripheral artery disease (PAD) using ATR‐FTIR microspectroscopy. Spectral signatures taken from muscle tissue samples predicted hemodynamic limitation and progression of the disease. The spectral biomarkers investigated may provide insight into new therapeutic targets.
Source: Physiological Reports - March 13, 2017 Category: Physiology Authors: Ryan A. Becker, Kim Cluff, Nithyanandhi Duraisamy, Hootan Mehraein, Hussam Farhoud, Tracie Collins, George P. Casale, Iraklis I. Pipinos, Jeyamkondan Subbiah Tags: Original Research Source Type: research

Mitochondrial Bioenergetics in the Metabolic Myopathy Accompanying Peripheral Artery Disease
Victoria G. Rontoyanni, Omar Nunez Lopez, Grant T. Fankhauser, Zulfiqar F. Cheema, Blake B. Rasmussen, Craig Porter
Source: Frontiers in Physiology - March 13, 2017 Category: Physiology Source Type: research

Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome
Abstract Barth syndrome (BTHS) is an X‐linked condition characterized by altered cardiolipin metabolism and cardioskeletal myopathy. We sought to compare cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with BTHS and unaffected controls and examine their relationships with cardiac function and exercise capacity. Children/adolescents and young adults with BTHS (n = 20) and children/adolescent and young adult control participants (n = 23, total n = 43) underwent 31P magnetic resonance spectroscopy (31P‐MRS) of the lower extremity (calf) and heart for estimation of skeletal muscle...
Source: Physiological Reports - February 13, 2017 Category: Physiology Authors: Adil Bashir, Kathryn L. Bohnert, Dominic N. Reeds, Linda R. Peterson, Adam J. Bittel, Lisa Fuentes, Christina A. Pacak, Barry J. Byrne, W. Todd Cade Tags: Original Research Source Type: research

Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in mitochondrial myopathy patients.
Abstract Muscle weakness and exercise intolerance negatively affect the quality of life of mitochondrial myopathy patients. Short-term dietary nitrate supplementation has been shown to improve exercise performance and reduce oxygen cost of exercise in healthy humans and trained athletes. We investigated if 1 week of dietary inorganic nitrate supplementation decreases the oxygen cost of exercise and improves mitochondrial function in mitochondrial myopathy patients. Ten mitochondrial myopathy patients (40 ± 5 years, maximal whole-body oxygen uptake = 21.2 ± 3.2 mL/min/kg body weight, maximal workload = 122 ± 26 ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - February 7, 2017 Category: Physiology Authors: Nabben M, Schmitz JP, Ciapaite J, Le Clercq CM, van Riel NA, Haak HR, Nicolay K, de Coo IF, Smeets HJ, Praet SF, van Loon LJ, Prompers JJ Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Critical Illness Myopathy (CIM) and Ventilator-Induced Diaphragm Muscle Dysfunction (VIDD): Acquired Myopathies Affecting Contractile Proteins.
Authors: Larsson L, Friedrich O Abstract Critical care and intensive care units (ICUs) have undergone dramatic changes and improvements in recent years, and critical care is today one of the fastest growing hospital disciplines. Significant improvements in treatments, removal of inefficient and harmful interventions, and introduction of advanced technological support systems have improved survival among critically ill ICU patients. However, the improved survival is associated with an increased number of patients with complications related to modern critical care. Severe muscle wasting and impaired muscle function a...
Source: Comprehensive Physiology - February 1, 2017 Category: Physiology Tags: Compr Physiol Source Type: research

Protein Structure-Function Relationship at Work: Learning from Myopathy Mutations of the Slow Skeletal Muscle Isoform of Troponin T
Anupom Mondal, J.-P. Jin
Source: Frontiers in Physiology - October 13, 2016 Category: Physiology Source Type: research

Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?
Steven B. Marston
Source: Frontiers in Physiology - September 25, 2016 Category: Physiology Source Type: research

Large copy-number variations in patients with statin-associated myopathy affecting statin myopathy-related loci.
Abstract Some patients are susceptible to statin-associated myopathy (SAM) either because of genetic variations affecting statin uptake and metabolism, or because they predispose their carriers to muscular diseases. Among the frequent variants examined using the genome-wide association study approach, SLCO1B1 c.521T>C represents the only validated predictor of SAM in patients treated with high-dose simvastatin. Our aim was to ascertain the overall contribution of large copy-number variations (CNVs) to SAM diagnosed in 86 patients. CNVs were detected by whole genome genotyping using Illumina HumanOmni2.5 Exome B...
Source: Physiological Research - August 18, 2016 Category: Physiology Authors: Stránecký V, Neřoldová M, Hodaňová K, Hartmannová H, Piherová L, Zemánková P, Přistoupilová A, Vrablík M, Adámková V, Kmoch S, Jirsa M Tags: Physiol Res Source Type: research

Molecular and Functional Effects of a Splice Site Mutation in the MYL2 Gene Associated with Cardioskeletal Myopathy and Early Cardiac Death in Infants
Zhiqun Zhou, Wenrui Huang, Jingsheng Liang, Danuta Szczesna-Cordary
Source: Frontiers in Physiology - June 16, 2016 Category: Physiology Source Type: research