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Vaccination: Influenza Vaccine
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Total 364 results found since Jan 2013.
Hemagglutinin-Based Universal Flu Vaccine Shows Early Promise Hemagglutinin-Based Universal Flu Vaccine Shows Early Promise
An influenza-vaccine candidate targeting the hemagglutinin (HA) stalk elicits cross-reactive antibodies in healthy human adults, according to interim results of a phase 1 clinical trial.Reuters Health Information
Source: Medscape Allergy Headlines - November 27, 2019 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
Safety of Live Attenuated Influenza Vaccine in Children with Moderate-Severe Asthma
In a phase IV, multicenter prospective cohort study of 478 children with asthma, LAIV did not cause a significant change in asthma control, including in preschool children and young people with poorly controlled or difficult asthma.
Source: Journal of Allergy and Clinical Immunology - December 17, 2019 Category: Allergy & Immunology Authors: Paul J. Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J. Andrews, Elizabeth Miller, SNIFFLE-4 Study Investigators Source Type: research
Broadly Protective Influenza Vaccine Comprising a Cocktail of Inactivated Avian Influenza Viruses
There is a great need for broadly protective, “universal” influenza virus vaccines given the antigenic drift and shift of influenza viruses and the variable protective efficacy of the current influenza vaccines. This technology relates to a broadly protective, “universal” influenza vaccine candidate composed of a cocktail of different l ow pathogenicity avian influenza virus subtypes inactivated by betapropiolactone (BPL). Vaccinating animals with BPL-inactivated whole virus vaccine comprising influenza virus strains belonging to four or more different low pathogenicity avian influenza hemagglutinin subtypes, intra...
Source: NIH OTT Licensing Opportunities - December 5, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research
A High-Yield Perfusion-Based Transient Gene Expression Bioprocess
Currently, fed-batch processes are the most commonly used bioprocesses in transient gene expression (TGE) vaccine manufacturing. However, because fed-batch processes keep all the cells and protein product in the vessel throughout the run, some limitations are intrinsic. First, waste products like cell debris or other unwanted small molecules accumulate in the vessel with a potential to disrupt the cell growth, protein production, and the stability of the generated protein of interest. Second, necessary buffer exchange and/or cell concentration steps must be performed outside of the culturing vessel. These steps are more in...
Source: NIH OTT Licensing Opportunities - December 2, 2019 Category: Research Authors: ajoyprabhu3 Source Type: research
Safety of live attenuated influenza vaccine (LAIV) in children with moderate to severe asthma
Live attenuated influenza vaccine (LAIV) is recommended for annual influenza vaccination in children from age 2 years. However, some guidelines recommend against its use in children with asthma or recurrent wheeze due to concerns over its potential to induce wheezing.
Source: Journal of Allergy and Clinical Immunology - December 17, 2019 Category: Allergy & Immunology Authors: Paul J. Turner, Louise Fleming, Sejal Saglani, Jo Southern, Nick J. Andrews, Elizabeth Miller, SNIFFLE-4 Study Investigators Source Type: research
Flu Vaccine ‘ Not A Very Good Match ’ For Strain That ’ s Tough On Children
(CNN) — This year’s flu vaccine is “not a very good match” for a common strain of the flu that’s especially tough on children, according to the nation’s top infectious disease doctor.
“It’s not a very good match for B/Victoria,” said Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, referring to the strain. “It’s not an awful match, but it’s not a very good match.”
Children are particularly susceptible to influenza B/Victoria.
Fauci said even though the match for B/Victoria isn’t great, a flu shot can...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 14, 2020 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Syndicated CBSN Boston CNN Flu Vaccine Source Type: news
Oral Flu Vaccine Well-Tolerated and Immunogenic Oral Flu Vaccine Well-Tolerated and Immunogenic
The VXA-A1.1 oral influenza vaccine was well tolerated and provided protective immunity against virus shedding similar to that of intramuscular inactivated influenza vaccine (IIV), in a phase II trial.Reuters Health Information
Source: Medscape Allergy Headlines - February 1, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
First childhood flu helps explain why virus hits some people harder than others
Why are some people better able to fight off the flu than others? Part of the answer, according to a new study, is related to the first flu strain we encounter in childhood.Scientists from UCLA and the University of Arizona have found that people ’s ability to fight off the flu virus is determined not only by the subtypes of flu they have had throughout their lives, but also by the sequence in which they are been infected by the viruses. Their study is published in the open-access journal PLoS Pathogens.The research offers an explanation for why some people fare much worse than others when infected with the same strain...
Source: UCLA Newsroom: Health Sciences - February 4, 2020 Category: Universities & Medical Training Source Type: news
Broadly Protective Strategies Against Influenza Viruses: Universal Vaccines and Therapeutics
Influenza virus is a respiratory pathogen that can cause disease in humans, with symptoms ranging from mild to life-threatening. The vast majority of influenza virus infections in humans are observed during seasonal epidemics and occasional pandemics. Given the substantial public health burden associated with influenza virus infection, yearly vaccination is recommended for protection against seasonal influenza viruses. Despite vigilant surveillance for new variants and careful selection of seasonal vaccine strains, the efficacy of seasonal vaccines can vary widely from year to year. This often results in lowered protection...
Source: Frontiers in Microbiology - February 6, 2020 Category: Microbiology Source Type: research
NIH Slated for 7 percent Budget Cut
The President has proposed a $38.7 billion budget for the National Institutes of Health in fiscal year (FY) 2021. This translates to a $3 billion or 7 percent cut in the agency’s funding compared to FY 2020.
The NIH budget request includes a $50 million initiative to use artificial intelligence (AI) to develop a better understanding of the causes of chronic diseases and to identify early treatments. This plan is in line with the Administration’s “Industries of the Future” effort, which supports using and developing AI across sectors.
The budget would provide $50 million for the Childhood Cancer ...
Source: Public Policy Reports - February 18, 2020 Category: Biology Authors: AIBS Source Type: news
Flu Vaccine Effectiveness Good This Season, CDC Says Flu Vaccine Effectiveness Good This Season, CDC Says
Preliminary estimates show influenza vaccine effectiveness for 2019-2020 was 55% in children and 45% overall, according to the Centers for Disease Control and Prevention.Medscape Medical News
Source: Medscape Allergy Headlines - February 20, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Source Type: news
FDA OKs Quadrivalent, Adjuvanted Flu Vaccine for Older Adults FDA OKs Quadrivalent, Adjuvanted Flu Vaccine for Older Adults
The quadrivalent version of Fluad was safe and effective against influenza strains included in the vaccine in multiple clinical studies with adults aged 65 years or older.News Alerts
Source: Medscape Allergy Headlines - February 24, 2020 Category: Allergy & Immunology Tags: Infectious Diseases News Alert Source Type: news
A computable phenotype for influenza vaccination status in patients with asthma
Upper respiratory infections are associated with up to 80% of asthma exacerbations. Investigating the role of influenza vaccination on asthma exacerbations using electronic health records (EHRs) is challenging due to lack of a computable phenotype for influenza vaccination. The purpose of this project was to develop an influenza vaccination computable phenotype, and evaluate its performance against manual chart review.
Source: Journal of Allergy and Clinical Immunology - January 31, 2020 Category: Allergy & Immunology Authors: Edwin Dovigi, Rafsa Khan, Pankaja Desai, Raj Shah, Ekta Kishen, Christopher Codispoti Source Type: research
Licensure of a New Hexavalent Vaccine for Use in Infants Licensure of a New Hexavalent Vaccine for Use in Infants
A new hexavalent vaccine for use in children aged 6 weeks through 4 years has been approved by the FDA to prevent diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b, and hepatitis B.Morbidity & Mortality Weekly Report
Source: Medscape Allergy Headlines - March 2, 2020 Category: Allergy & Immunology Tags: Public Health & Prevention Journal Article Source Type: news
World Health Organization Declares COVID-19 a ‘Pandemic.’ Here’s What That Means
The World Health Organization (WHO) on March 11 declared COVID-19 a pandemic, pointing to the over 118,000 cases of the coronavirus illness in over 110 countries and territories around the world and the sustained risk of further global spread.
“This is not just a public health crisis, it is a crisis that will touch every sector,” said Dr. Tedros Adhanom Ghebreyesus, WHO director-general, at a media briefing. “So every sector and every individual must be involved in the fights.”
An epidemic refers to an uptick in the spread of a disease within a specific community. By contrast, the WHO defines a pand...
Source: TIME: Health - March 11, 2020 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized COVID-19 Source Type: news
