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Total 540 results found since Jan 2013.

Th17 cells and tissue remodeling in atopic and contact dermatitis
ConclusionThe expression of IL‐17 and related cytokines, such as IL‐22, was demonstrated in acute eczematous lesions independent of their pathogenesis. Our results suggest a potential role for IL‐17 in remodeling of the skin.
Source: Allergy - November 1, 2013 Category: Allergy & Immunology Authors: D. Simon, C. Aeberhard, Y. Erdemoglu, H.‐U. Simon Tags: Original Article Source Type: research

News Beyond Our Pages
Viral, bacterial, and fungal infections are recognized by the innate immune system through pattern-recognition receptors, such as Toll-like receptors, but the mechanism by which the innate immune system recognizes helminths and allergens remains largely unknown. It has been proposed that allergens are detected through sensing their activity because many allergens have enzymatic activity and can induce tissue damage. It has been further proposed that the purpose of the TH2 immune response that is mounted against such allergens is to protect against or initiate repair of damaged tissue. Two articles published simultaneously ...
Source: Journal of Allergy and Clinical Immunology - December 26, 2013 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson Tags: News beyond our pages Source Type: research

High-content cytometry and transcriptomic biomarker profiling of human B-cell activation
Conclusion: The biomarkers found in this study could be used to further study the complex process of B-cell activation and to understand conditions that lead to the development of primary antibody deficiencies.
Source: Journal of Allergy and Clinical Immunology - September 9, 2013 Category: Allergy & Immunology Authors: Christian Hennig, Claudia Ilginus, Kaan Boztug, Julia Skokowa, Laszlo Marodi, Anna Szaflarska, Mareike Sass, Claudio Pignata, Sara Sebnem Kilic, Isabel Caragol, Ulrich Baumann, Christoph Klein, Karl Welte, Gesine Hansen Tags: Immune deficiencies, infection, and systemic immune disorders Source Type: research

Thriving in 2013: A year in review
2013 was a year of varying emotion in Boston—from the tragedy of the marathon bombings to the elation of the first World Series victory at Fenway Park in nearly a century. And if the past 12 months have taught me anything, it’s that learning to appreciate the good moments and figuring out how to stay strong during the difficult times are what truly define our strength of character. It’s an important life lesson, and one that stayed with me as I compiled the top Thriving stories of 2013. The following blogs document many of the great achievements our staff and patients experienced in 2013, as well as the coura...
Source: Thrive, Children's Hospital Boston - December 31, 2013 Category: Pediatrics Authors: Tripp Underwood Tags: All posts patient stories Source Type: news

Skin Repair Properties of d-Limonene and Perillyl Alcohol in Murine Models
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - February 9, 2014 Category: Allergy & Immunology Authors: A. d'Alessio, PatriziaMirshahi, MassoudBisson, Jean-FrancoisC. Bene, Marie Tags: Articles Source Type: research

A common atopy‐associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding
ConclusionThe human RHS7 critically contributes to the regulation of gene transcription, and the common atopy‐associated polymorphism rs2240032 impacts transcriptional activity and transcription factor binding.
Source: Allergy - March 25, 2014 Category: Allergy & Immunology Authors: A. Kretschmer, G. Möller, H. Lee, H. Laumen, C. Toerne, K. Schramm, H. Prokisch, S. Eyerich, S. Wahl, H. Baurecht, A. Franke, M. Claussnitzer, K. Eyerich, A. Teumer, L. Milani, N. Klopp, S. M. Hauck, T. Illig, A. Peters, M. Waldenberger, J. Adamski, E. R Tags: Original Article Source Type: research

News Beyond Our Pages
Vitamin A deficiency is a common nutrient deficiency primarily affecting children in which helminth infections are prevalent. It is known that this micronutrient supports the adaptive immune system through its metabolite, retinoic acid. Spencer et al (Science 2014;343:432-6) examined the possibility that innate lymphoid cells (ILCs), which are known to be involved in barrier maintenance, tissue repair, and host defense, can sustain barrier defense during vitamin A deficiency. The authors discovered that although the deficiency diminishes the adaptive immune system and type 3 ILCs, a dramatic expansion of IL-13–producing ...
Source: Journal of Allergy and Clinical Immunology - March 31, 2014 Category: Allergy & Immunology Authors: Marc E. Rothenberg, Jean Bousquet, Patricia C. Fulkerson Tags: News beyond our pages Source Type: research

Somatic reversion in dedicator of cytokinesis 8 immunodeficiency modulates disease phenotype
Conclusions: In patients with DOCK8 deficiency, only certain combinations of germline mutations supported secondary somatic repair. Those patients had an ameliorated disease course with longer survival but still had fatal complications or required hematopoietic cell transplantation. These observations support the concept that some DOCK8-immunodeficient patients have mutable mosaic genomes that can modulate disease phenotype over time.
Source: Journal of Allergy and Clinical Immunology - May 5, 2014 Category: Allergy & Immunology Authors: Huie Jing, Qian Zhang, Yu Zhang, Brenna J. Hill, Christopher G. Dove, Erwin W. Gelfand, T. Prescott Atkinson, Gulbu Uzel, Helen F. Matthews, Peter J. Mustillo, David B. Lewis, Fotini D. Kavadas, I. Celine Hanson, Ashish R. Kumar, Raif S. Geha, Daniel C. D Tags: Immune deficiencies, infection, and systemic immune disorders Source Type: research

Re‐defining the Unique Roles for Eosinophils in Allergic Respiratory Inflammation
This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - June 24, 2014 Category: Allergy & Immunology Authors: Elizabeth A. Jacobsen, Nancy A. Lee, James J. Lee Tags: Invited Review Source Type: research

NIH launches 3D Print Exchange
The National Institutes of Health (NIH) recently launched the NIH 3D Print Exchange, a public website that enables users to share, download, and edit 3D print files related to health and science. These files can be used, for example, to print custom laboratory equipment and models of bacteria and human anatomy. The NIH 3D Print Exchange also provides video tutorials and additional resources with instruction on 3D modeling software to enable users to customize and create 3D prints. “3D printing is a potential game changer for medical research,” said NIH Director Francis S. Collins, M.D., Ph.D. “At NIH, we have seen an...
Source: Network News - June 24, 2014 Category: Databases & Libraries Authors: Emily Hurst Tags: General (all entries) Technology 3d 3d printing NIH open data open science Source Type: news

Prospective long term follow-up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)
Conclusions The incidence of ASD is maximal within the first 5 years after diagnosis but continues developing over time, affecting up to 33.3% of individuals after long term follow-up. Once ASD occurs, dilatation increases over time, underlining the need for periodic evaluation. Surgical repair is feasible in about one-third of candidates.
Source: Annals of the Rheumatic Diseases - September 4, 2014 Category: Rheumatology Authors: Garcia-Martinez, A., Arguis, P., Prieto-Gonzalez, S., Espigol-Frigole, G., Alba, M. A., Butjosa, M., Tavera-Bahillo, I., Hernandez-Rodriguez, J., Cid, M. C. Tags: Immunology (including allergy), Pathology, Radiology, Vascularitis, Surgical diagnostic tests, Clinical diagnostic tests, Epidemiology Clinical and epidemiological research Source Type: research

Allergic Contact Dermatitis in Atopic Dermatitis
Opinion statement Atopic dermatitis (AD) is a common chronic inflammatory skin disease resulting from a disrupted barrier function and an altered immune mechanism. Sometimes, it is difficult to distinguish between AD, irritant contact dermatitis (ICD), and allergic contact dermatitis (ACD) because they all present as eczematous dermatitis and may co-exist. Impaired barrier function in AD predisposes to the development of both ACD and ICD, as these three conditions share some mechanisms. The prevalence of ACD is at least as common in AD patients as in the general population; therefore, patients with chronic recalci...
Source: Current Treatment Options in Allergy - July 30, 2014 Category: Allergy & Immunology Source Type: research

TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction
IL-13 is a pleiotropic cytokine that provokes diverse pathophysiological outcomes. Although its effect during gastrointestinal helminth infection is prototypic of a protective TH2 response (increased peristalsis, goblet cell hyperplasia and mucus secretion, eosinophil recruitment, fibroblast activation, and wound repair), temporal or spatial dysregulation of this response is thought to underlie diseases such as asthma, allergic hyperreactivity, and organ fibrosis.1 IL-13 signals via the IL-13Rα1/IL-4Rα heterodimer to induce several genes specific to TH2 inflammation including CCL26, CCL11, POSTN, and MUC5AC.
Source: Journal of Allergy and Clinical Immunology - June 20, 2014 Category: Allergy & Immunology Authors: Vahe Badalyan, Robert Thompson, Kezia Addo, Lee A. Borthwick, Andrew J. Fisher, Tatiana Ort, Timothy G. Myers, Thomas A. Wynn, Thirumalai R. Ramalingam Tags: Letter to the Editor Source Type: research

Acrylate-induced allergic contact dermatitis in a car windscreen repairer
We report a case of an allergic skin reaction to ultraviolet-cured acrylates in a windscreen repair worker. The patient presented with a 6 month history of fingertip dryness, vesicles and desquamation. He had worked as a self-employed car windscreen repairer for 19 years. Previous management with vinyl glove protection and treatment with clobetasol propionate ointment had produced little improvement. He was patch tested to the British Society for Cutaneous Allergy standard and preservatives series and to the two acrylates used in his work environment, identified using safety data sheets, methyl methacrylate 2% pet and 2-hy...
Source: Occupational Medicine - October 2, 2014 Category: Respiratory Medicine Authors: Fremlin, G., Sansom, J. Tags: Dermatological disorders Case Report Source Type: research

Systems biology approaches to understanding Epithelial Mesenchymal Transition (EMT) in mucosal remodeling and signaling in asthma
Abstract A pathological hallmark of asthma is chronic injury and repair, producing dysfunction of the epithelial barrier function. In this setting, increased oxidative stress, growth factor- and cytokine stimulation, together with extracellular matrix contact produces transcriptional reprogramming of the epithelial cell. This process results in epithelial-mesenchymal transition (EMT), a cellular state associated with loss of epithelial polarity, expression of mesenchymal markers, enhanced mobility and extracellular matrix remodeling. As a result, the cellular biology of the EMT state produces characteristic chang...
Source: World Allergy Organization Journal - June 2, 2014 Category: Allergy & Immunology Source Type: research