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Procedure: Gastroschisis Repair

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Total 540 results found since Jan 2013.

TGF-β1 polymorphisms and asthma severity, airway inflammation, and remodeling
The development and progression of asthma are determined by multiple genetic and environmental factors. A relatively new hypothesis is that chronic injury by environmental irritants and/or defective repair of the airway epithelium leads to the release of cytokines and growth factors. These factors drive chronic airway inflammation and remodeling seen in asthma. Airway inflammation and remodeling are 2 important pathologic features associated with airway hyperresponsiveness (AHR) and fixed airflow obstruction.
Source: Journal of Allergy and Clinical Immunology - October 29, 2012 Category: Allergy & Immunology Authors: Despo Ierodiakonou, Dirkje S. Postma, Gerard H. Koppelman, Jorrit Gerritsen, Nick H.T. ten Hacken, Wim Timens, H. Marike Boezen, Judith M. Vonk Tags: Letters to the Editor Source Type: research

Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study
Conclusions Blockade of IL-6R by tocilizumab can induce limited repair in a subset of erosions, particularly in large lesions with sclerosis. Repair of erosions during tocilizumab treatment reflects the favourable impact of IL-6R blockade on local bone remodelling in patients with RA.
Source: Annals of the Rheumatic Diseases - February 5, 2013 Category: Rheumatology Authors: Finzel, S., Rech, J., Schmidt, S., Engelke, K., Englbrecht, M., Schett, G. Tags: Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

B-cell reconstitution for SCID: Should a conditioning regimen be used in SCID treatment?
Bone marrow transplantation has resulted in life-saving sustained T-cell reconstitution in many infants with severe combined immunodeficiency (SCID), but correction of B-cell function has been more problematic. At the annual meeting of the Primary Immunodeficiency Treatment Consortium held in Boston, Massachusetts, on April 27, 2012, a debate was held regarding the use of pretransplantation conditioning versus no pretransplantation conditioning in an effort to address this problem. Reviews of the literature were made by both debaters, and there was agreement that there was a higher rate of B-cell chimerism and a lower numb...
Source: Journal of Allergy and Clinical Immunology - March 5, 2013 Category: Allergy & Immunology Authors: Elie Haddad, Sandrine Leroy, Rebecca H. Buckley Tags: Current perspectives Source Type: research

Epstein-Barr virus–independent diffuse large B-cell lymphoma in DNA ligase 4 deficiency
We report on one of the first patients, 411BR, who carried a homozygous 833G>A/R278H mutation and 2 cooperating homozygous N-terminal single nucleotide polymorphisms. Despite remaining well for many years, albeit with profound learning difficulties, persistent anemia, thrombocytopenia and lymphopenia, bronchiectasis, and combined immunodeficiency treated with immunoglobulin replacement (see in this article's Online Repository at www.jacionline.org), he re-presented at 23 years of age with rapidly enlarging cervical lymphadenopathy. EBV was negative in blood by PCR. Biopsy revealed diffuse large B-cell lymphoma (DLBCL). Com...
Source: Journal of Allergy and Clinical Immunology - December 10, 2012 Category: Allergy & Immunology Authors: Chris M. Bacon, Sarah J. Wilkinson, Gavin P. Spickett, Dawn Barge, Helen H. Lucraft, Graham Jackson, Vikki Rand, Andrew R. Gennery Tags: Letters to the Editor Source Type: research

Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity
Conclusion: The severity of the antibody deficiency in patients with AT correlates with disturbances in B- and T-cell homeostasis resulting in reduced immune repertoire diversity, which consequently affects the chance of successful antigen-dependent cognate B-T interaction.
Source: Journal of Allergy and Clinical Immunology - April 8, 2013 Category: Allergy & Immunology Authors: Gertjan J. Driessen, Hanna IJspeert, Corry M.R. Weemaes, Ásgeir Haraldsson, Margreet Trip, Adilia Warris, Michiel van der Flier, Nico Wulffraat, Mijke M.M. Verhagen, Malcolm A. Taylor, Menno C. van Zelm, Jacques J.M. van Dongen, Marcel van Deuren, Mirjam Tags: Immune deficiencies, infection, and systemic immune disorders Source Type: research

Pollution may increase diabetes risk
Conclusion This German study looked at the relationship between air pollution and proximity to the nearest road at the child’s birth address, and the child’s insulin resistance when they were aged 10. Though links were found between increasing levels of nitrogen dioxide and levels of particles less than 10 micrometres in diameter and increasing insulin levels at age 10, there are important limitations to bear in mind: Though the researchers have attempted to adjust for many potential confounders, it is difficult to conclude that the air pollution at the birth address has directly caused the child’s insulin resista...
Source: NHS News Feed - May 10, 2013 Category: Consumer Health News Tags: Diabetes Lifestyle/exercise Source Type: news

Notch signalling pathways mediate synovial angiogenesis in response to vascular endothelial growth factor and angiopoietin 2
Conclusions Notch-1 mediates VEGF/Ang2-induced angiogenesis and EC invasion in inflammatory arthritis.
Source: Annals of the Rheumatic Diseases - May 10, 2013 Category: Rheumatology Authors: Gao, W., Sweeney, C., Walsh, C., Rooney, P., McCormick, J., Veale, D. J., Fearon, U. Tags: Open access, Immunology (including allergy), Pathology, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Surgical diagnostic tests, Clinical diagnostic tests Basic and translational research Source Type: research

Beyond dna repair,the immunological role of parp-1 and its siblings.
Abstract ADP-ribosylation is the addition of one or more (up to some hundreds) ADP-ribose moieties to acceptor proteins. There are two major families of enzymes that catalyze this reaction: extracellular ADP-ribosyl-transferases (ARTs), which are bound to the cell membrane by a GPI anchor or are secreted, and poly(ADP-ribose)-polymerases (PARPs), which are present in the cell nucleus and/or cytoplasm. Recent findings revealed a wide immunological role for ADP-ribosylating enzymes. ARTs, by sensing extracellular NAD concentration, can act as danger detectors. PARP-1, the prototypical representative of the PARP fami...
Source: Immunology - March 15, 2013 Category: Allergy & Immunology Authors: Rosado MM, Bennici E, Novelli F, Pioli C Tags: Immunology Source Type: research

Superior Vena Cava Stenting Guided by Alternative Imaging Modalities in a Patient with Severe Contrast Allergy: A Case Report and Brief Literature Review
We present a case of a 52‐year‐old woman with a sinus venosus atrial septal defect and partial anomalous pulmonary venous connection status post repair who presented with superior vena cava graft obstruction. Two overlapping stents were placed within the superior vena cava using gadolinium, CO2 angiography and transesophageal echocardiography for visualization of the graft stenoses. No iodinated media were used.
Source: Congenital Heart Disease - June 30, 2013 Category: Cardiology Authors: Priya Pillutla, Leigh C. Reardon, Jamil A. Aboulhosn Tags: Case Report Source Type: research

Serum proteins reflecting inflammation, injury and repair as biomarkers of disease activity in ANCA-associated vasculitis
Conclusions Many markers are elevated in severe active AAV and decline with treatment, but CXCL13, MMP-3 and TIMP-1 distinguish active AAV from remission better than the other markers studied, including ESR and CRP. These proteins are particularly promising candidates for future studies to address unmet needs in the assessment of patients with AAV.
Source: Annals of the Rheumatic Diseases - July 4, 2013 Category: Rheumatology Authors: Monach, P. A., Warner, R. L., Tomasson, G., Specks, U., Stone, J. H., Ding, L., Fervenza, F. C., Fessler, B. J., Hoffman, G. S., Ikle, D., Kallenberg, C. G., Krischer, J., Langford, C. A., Mueller, M., Seo, P., St. Clair, E. W., Spiera, R., Tchao, N., Ytt Tags: Immunology (including allergy), Inflammation, Renal medicine, Interstitial lung disease, Vascularitis, Epidemiology Clinical and epidemiological research Source Type: research

Pathogenesis of Exercise-Induced Bronchoconstriction
This article presents the various potential mechanisms responsible for the development of exercise-induced bronchoconstriction (EIB). Although the etiology of EIB is multifactorial, and the physiologic processes involved may vary between individuals (especially between those with and without asthma), drying of the small airways with an associated inflammatory response seems prerequisite for EIB. Dysregulated repair processes following exercise-induced airway epithelial injury may also serve as basis for EIB development/progression.
Source: Immunology and Allergy Clinics of North America - April 8, 2013 Category: Allergy & Immunology Authors: Pascale Kippelen, Sandra D. Anderson Source Type: research

Advanced age influences the dynamic changes in circulating C-reactive protein following injury
Conclusions CRP decline following insult is delayed in elderly patients as a result of unopposed IL-6 release. Age should be routinely incorporated in the assessment of CRP response to avoid misinterpretation of age-related delay in CRP clearance with ongoing systemic inflammation.
Source: Journal of Clinical Pathology - July 22, 2013 Category: Pathology Authors: Pinato, D. J., Bains, J., Irkulla, S., Pomroy, J., Ujam, B., Gaze, D., Mendall, M. A. Tags: Immunology (including allergy), Inflammation Original article Source Type: research

Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis
Conclusions These data suggest that sclerostin inhibition is a powerful tool to enhance bone repair in inflammatory arthritis.
Source: Annals of the Rheumatic Diseases - September 4, 2013 Category: Rheumatology Authors: Chen, X.-X., Baum, W., Dwyer, D., Stock, M., Schwabe, K., Ke, H.-Z., Stolina, M., Schett, G., Bozec, A. Tags: Open access, Genetics, Immunology (including allergy), Inflammation, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Pathogenesis of Exercise-Induced Bronchoconstriction
This article presents the various potential mechanisms responsible for the development of exercise-induced bronchoconstriction (EIB). Although the etiology of EIB is multifactorial, and the physiologic processes involved may vary between individuals (especially between those with and without asthma), drying of the small airways with an associated inflammatory response seems prerequisite for EIB. Dysregulated repair processes following exercise-induced airway epithelial injury may also serve as basis for EIB development/progression.
Source: Immunology and Allergy Clinics of North America - April 8, 2013 Category: Allergy & Immunology Authors: Pascale Kippelen, Sandra D. Anderson Source Type: research

Primary lysis of eosinophils in severe desquamative asthma
ConclusionEosinophil lysis and FEGs belong to the disease picture of severe asthma and need consideration in asthma studies concerned with: phenotypes, biomarkers, roles of epithelial injury/repair, and targeting novel drugs.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - December 1, 2013 Category: Allergy & Immunology Authors: Carl Persson Tags: Invited Review Source Type: research