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Other Phenotypes and Treatment of Chronic Rhinosinusitis
This article comments on some factors that are believed to influence the expression of CRS. These factors include anatomic abnormalities, immotile cilia, age, allergic sensitization, immune deficiency, dental infections, gastrointestinal reflux, smoking, biofilm, and the microbiome. Other factors are discussed in other sections. The article concludes with an overview of treatment. In brief, nasal steroids and large volume nasal irrigations are the first line of treatment for this inflammatory disease. Antibiotics are used when infections are thought to contribute. Oral steroids are frequently used in severe disease. Endosc...
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 6, 2016 Category: Allergy & Immunology Source Type: research

Varied incidence of immediate adverse reactions to low ‐osmolar non‐ionic iodide radiocontrast media used in computed tomography
ConclusionsThe incidence of immediate ADRs varied according to the low‐osmolar nonionic RCM used. Iopromide‐induced immediate ADRs were more frequent, while iobitridol was associated with fewer immediate ADRs than other RCMs. Multiple CT examinations per day resulted in a higher incidence of immediate ADRs and anaphylaxis than a single CT examination. Clinicians should consider these risk differences of immediate ADRs when prescribing contrasted CT examinations.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - August 31, 2016 Category: Allergy & Immunology Authors: Sung Ryeol Kim, Jae ‐Hyun Lee, Kyung Hee Park, Hye Jung Park, Jung Won Park Tags: Original Article ‐Clinical Allergy Source Type: research

The relationship between biomarkers of fungal allergy and lung damage in asthma
ConclusionsIgE sensitisation to thermotolerant filamentous fungi, in particular A. fumigatus but not total IgE, is associated with fixed airflow obstruction and a number of radiological abnormalities in moderate to severe asthma. All patients with IgE sensitisation to A. fumigatus are at risk of lung damage irrespective of whether they meet the criteria for ABPA.This article is protected by copyright. All rights reserved.
Source: Clinical and Experimental Allergy - October 31, 2016 Category: Allergy & Immunology Authors: Kerry F. Woolnough, Matthew Richardson, Christopher Newby, Michelle Craner, Michelle Bourne, William Monteiro, Salman Siddiqui, Peter Bradding, Catherine H. Pashley, Andrew J. Wardlaw Tags: Original Article ‐Asthma and Rhinitis Source Type: research

IgE plasma level in asthmatics with nasal polyps is independent of atopy
CONCLUSIONS. In asthmatic patients with rhinitis and CRSsNP, IgE plasma levels are elevated according to atopy while in those with CRSwNP, IgE plasma levels were independent of atopy.
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Castillo Vizuete, J. A., Picado, C., Plaza, V., Rodrigo, G., Julia, B., Mullol, J. Tags: 5.3 Allergy and Immunology Source Type: research

Journal Allergy & Clinical Immunology Perspective: Clinical potential for imaging in asthma and other lung disorders
The ability of lung imaging to phenotype patients, determine prognosis, and to predict response to treatments is expanding in clinical and translational research. The purpose of this perspective is to describe current imaging modalities that may be useful clinical tools in asthma and other lung disorders and to explore some of the new developments in imaging modalities of the lung. These imaging modalities include chest radiography (CXR), computed tomography (CT), lung magnetic resonance imaging (MRI), electrical impedance tomography (EIT), bronchoscopy, and others.
Source: Journal of Allergy and Clinical Immunology - November 17, 2016 Category: Allergy & Immunology Authors: Emily M. DeBoer, David R. Spielberg, Alan S. Brody Source Type: research

Examination of high ‐antibiotic users in a multi‐institutional cohort of chronic rhinosinusitis patients
ConclusionVariability in antibiotic use in CRS appears to be driven by symptom burden, independent of objective measures of disease severity, patient demographics, and presence of comorbid disease. Clear guidelines are essential to define appropriate antibiotic use in CRS.
Source: International Forum of Allergy and Rhinology - December 31, 2016 Category: Allergy & Immunology Authors: Vijay R. Ramakrishnan, Jess C. Mace, Zachary M. Soler, Timothy L. Smith Tags: ORIGINAL ARTICLE Source Type: research

British Lung Foundation/United Kingdom Primary Immunodeficiency Network Consensus Statement on the Definition, Diagnosis, and Management of Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency Disorders
Publication date: Available online 25 March 2017 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): John R. Hurst, Nisha Verma, David Lowe, Helen E. Baxendale, Stephen Jolles, Peter Kelleher, Hilary J. Longhurst, Smita Y. Patel, Elisabetta A. Renzoni, Clare R. Sander, Gerard R. Avery, Judith L. Babar, Matthew S. Buckland, Siobhan Burns, William Egner, Mark M. Gompels, Pavels Gordins, Jamanda A. Haddock, Simon P. Hart, Grant R. Hayman, Richard Herriot, Rachel K. Hoyles, Aarnoud P. Huissoon, Joseph Jacob, Andrew G. Nicholson, Doris M. Rassl, Ravishankar B. Sargur, Sinisa Savic, Suranjith L. Senevi...
Source: The Journal of Allergy and Clinical Immunology: In Practice - March 26, 2017 Category: Allergy & Immunology Source Type: research

Radiographic Evidence of Sinonasal Inflammation in Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome: An Underrecognized Association
Conclusions Radiographic evidence of sinonasal inflammation was a common comorbidity in ACOS. Future studies are required to examine the role of sinonasal inflammation in ACOS.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 29, 2017 Category: Allergy & Immunology Source Type: research

Lack of Efficacy of Symptoms and Medical History in Distinguishing the Degree of Eosinophilia in Nasal Polyps
Conclusions The ability to individualize therapies for NP is dependent on identifying clinical features or biomarkers of eosinophilia. However, with the exception of circulating eosinophilia, we could not identify a clinical feature or biomarker that robustly predicted the presence of tissue eosinophilia. Even more problematic, even the seeming “criterion standard” determination of tissue pathology was of limited value, as our cohort displayed a continuous spectrum of tissue eosinophil expression, making arbitrary any definitive cutoff distinguishing these conditions.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 10, 2017 Category: Allergy & Immunology Source Type: research

Biotherapeutics in Chronic Rhinosinusitis with and without Nasal Polyps
Publication date: Available online 16 May 2017 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Claus Bachert, Philippe Gevaert, Peter Hellings In western countries, 85% of chronic rhinosinusitis with nasal polyp disease reveals a type 2 inflammatory pattern with expression of IL-4, -5, and -13 as well as increased concentrations of IgE, whereas chronic rhinosinusitis without nasal polyps merely expresses these biomarkers. The degree of type 2 inflammation furthermore is associated with disease severity, asthma comorbidity, and recurrence of disease after surgery. Therefore, these biomarkers a...
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 17, 2017 Category: Allergy & Immunology Source Type: research

A 17-year-old male with a Small Bowel Neuroendocrine Tumor: flushing differential diagnosis
ConclusionsNETs can present as carcinoid syndrome (flushing, diarrhea, abdominal pain, wheezing), which constitutes vague symptomatology and represents a challenging diagnosis for physicians. They can be confused with an allergic reaction and the allergist should consider it as a differential diagnosis. Accurate diagnostic tests will help to diagnose NETs earlier and potentially prevent carcinoid heart disease, bowel obstruction, and improve quality of life and mortality in these patients.
Source: World Allergy Organization Journal - September 4, 2017 Category: Allergy & Immunology Source Type: research

Computed tomography analysis of frontal cell prevalence according to the International Frontal Sinus Anatomy Classification
International Forum of Allergy&Rhinology, EarlyView.
Source: International Forum of Allergy and Rhinology - February 19, 2018 Category: Allergy & Immunology Authors: GarretChobyMD , AndrewThambooMD , Tae ‐BinWonMD, PhD , JooyeonKimMD , Liang ChunShihMD , Peter H.HwangMD Source Type: research

Preoperative Lund ‐Mackay computed tomography score is associated with preoperative symptom severity and predicts quality‐of‐life outcome trajectories after sinus surgery
International Forum of Allergy&Rhinology, EarlyView.
Source: International Forum of Allergy and Rhinology - March 8, 2018 Category: Allergy & Immunology Authors: Steven G.BrooksMPH , MichalTropeMD , MarielBlasettiBS , LaurelDoghramjiRN , ArjunParasherMD , Jordan T.GlicksmanMD, MPH , David W.KennedyMD , Erica R.ThalerMD , Noam A.CohenMD, PhD , James N.PalmerMD , Nithin D.AdappaMD Source Type: research

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