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Total 443 results found since Jan 2013.

Relationship between radiographic joint space narrowing, sonographic cartilage thickness and anatomy in rheumatoid arthritis and control joints
Conclusions Sonographic cartilage assessment in MCPs is closely related to anatomical cartilage thickness. Both JSW and JSN by radiography represent cartilage thickness in the MCP joints of patients with RA quite well. Thus, US is a valid tool for measuring MCT if radiographs are not available or in case of joint malalignment.
Source: Annals of the Rheumatic Diseases - October 9, 2015 Category: Rheumatology Authors: Mandl, P., Supp, G., Baksa, G., Radner, H., Studenic, P., Gyebnar, J., Kurucz, R., Niedermayer, D., Aletaha, D., Balint, P. V., Smolen, J. S. Tags: Immunology (including allergy), Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

Dactylitis warns of future damage in psoriatic arthritis
Baseline radiographic damage and the presence of dactylitis at 5 years are independent predictors of further joint destruction in people with psoriatic arthritis, according to follow-up data from a psoriatic arthritis registry. The analysis of hand and foot radiographic findings from 72 patients...
Source: Skin and Allergy News - October 20, 2015 Category: Dermatology Source Type: news

Assessment of pneumatization of the paranasal sinuses: a comprehensive and validated metric
ConclusionThe APPS score is the first comprehensive and validated metric for quantifying the degree of paranasal sinus pneumatization and anatomic variation. This has important potential utility in standardizing evaluation of sinus CT and researching the relationship of sinus pneumatization with clinical parameters.
Source: International Forum of Allergy and Rhinology - December 1, 2015 Category: Allergy & Immunology Authors: Michael J. Marino, Jacqueline E. Weinstein, Charles A. Riley, Joshua M. Levy, Noah A. Emerson, Edward D. McCoul Tags: ORIGINAL ARTICLE Source Type: research

The first double-blind, randomised, parallel-group certolizumab pegol study in methotrexate-naive early rheumatoid arthritis patients with poor prognostic factors, C-OPERA, shows inhibition of radiographic progression
Conclusions In MTX-naive early RA patients with poor prognostic factors, CZP+MTX significantly inhibited structural damage and reduced RA signs and symptoms, demonstrating the efficacy of CZP in these patients. Trial registration number (NCT01451203).
Source: Annals of the Rheumatic Diseases - December 11, 2015 Category: Rheumatology Authors: Atsumi, T., Yamamoto, K., Takeuchi, T., Yamanaka, H., Ishiguro, N., Tanaka, Y., Eguchi, K., Watanabe, A., Origasa, H., Yasuda, S., Yamanishi, Y., Kita, Y., Matsubara, T., Iwamoto, M., Shoji, T., Okada, T., van der Heijde, D., Miyasaka, N., Koike, T. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

MRI findings predict radiographic progression and development of erosions in hand osteoarthritis
Conclusions BMLs, synovitis and JSN were the strongest predictors for radiographic progression. Malalignment was associated with incident erosions only. Future studies should explore whether reducing BMLs and inflammation can decrease the risk of structural progression.
Source: Annals of the Rheumatic Diseases - December 11, 2015 Category: Rheumatology Authors: Haugen, I. K., Slatkowsky-Christensen, B., Boyesen, P., Sesseng, S., van der Heijde, D., Kvien, T. K. Tags: Immunology (including allergy), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Clinical diagnostic tests, Radiology (diagnostics) Clinical and epidemiological research Source Type: research

MRI assessment of suppression of structural damage in patients with rheumatoid arthritis receiving rituximab: results from the randomised, placebo-controlled, double-blind RA-SCORE study
Conclusions This study demonstrated that rituximab significantly reduced erosion and cartilage loss at week 24 and week 52 in MTX-inadequate responder patients with active RA, suggesting that MRI is a valuable tool for assessing inflammatory and structural damage in patients with established RA receiving rituximab. Trial registration number NCT00578305
Source: Annals of the Rheumatic Diseases - December 11, 2015 Category: Rheumatology Authors: Peterfy, C., Emery, P., Tak, P. P., Ostergaard, M., DiCarlo, J., Otsa, K., Navarro Sarabia, F., Pavelka, K., Bagnard, M.-A., Gylvin, L. H., Bernasconi, C., Gabriele, A. Tags: Open access, Immunology (including allergy), Bone and joint infections, Inflammation, Radiology, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Clinical diagnostic tests, Radiology (diagnostics), Ca Source Type: research

Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression
Conclusions A clinically well-tolerated CDK4/6 inhibitor exerted antiarthritic effects in this mouse model. By combining therapeutic agents targeting immune reaction and synovial proliferation, we have demonstrated for the first time that two molecular targeting treatments act additively and may not increase immune suppression.
Source: Annals of the Rheumatic Diseases - December 11, 2015 Category: Rheumatology Authors: Hosoya, T., Iwai, H., Yamaguchi, Y., Kawahata, K., Miyasaka, N., Kohsaka, H. Tags: Immunology (including allergy), Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis Basic and translational research Source Type: research

Bronchoscopy in patients with haemoptysis and normal computed tomography of the chest is unlikely to result in significant findings.
CONCLUSION: CT should be used as first-line examination in patients with a history of haemoptysis. Furthermore, in patients above 40 years of age with positive findings of any kind on the CT, further examination with FOB is indicated. However, if the chest CT is without pathological findings, it is most unlikely that FOB will reveal anything of significance. FUNDING: none. TRIAL REGISTRATION: not relevant. PMID: 26239592 [PubMed - in process]
Source: Danish Medical Journal - December 12, 2015 Category: Journals (General) Tags: Dan Med J Source Type: research

Transient Cardiomyopathy and Quadriplegia Induced by Ephedrine Decongestant.
We report the case of an otherwise healthy 37-year-old woman who presented with acute-onset quadriplegia and heart failure. She had a normal chest radiograph on admission, but developed marked pulmonary edema and bilateral effusions the next day. Echocardiography revealed a left ventricular ejection fraction of 0.18 and no obvious intrinsic pathologic condition such as foramen narrowing on spinal imaging. Laboratory screening was positive for methamphetamines in the urine, and the patient admitted to having used, over the past several weeks, multiple ephedrine-containing products for allergy-symptom relief. She was ultimat...
Source: Texas Heart Institute Journal - December 1, 2015 Category: Cardiology Authors: Snipelisky DF, Kurklinsky AK, Chirila R Tags: Tex Heart Inst J Source Type: research

Transnasal endoscopic medial maxillary sinus wall transposition with preservation of structures
ConclusionsTEMMT provides excellent access into the MS, especially the floor and anterior wall, without the morbidities of the Caldwell‐Luc or medial maxillectomy approach. In addition, the transposition of the inferior turbinate and the mucosal flap provides coverage of the medial wall with preservation of the inferior meatus, inferior turbinate, and nasolacrimal duct for patients with benign MS disease. Level of EvidenceNA Laryngoscope, 2015
Source: The Laryngoscope - December 21, 2015 Category: ENT & OMF Authors: Alice Z. Maxfield, Tiffany T. Chen, Tiago F. Scopel, Robert Engle, Kristina Piastro, Anna Butrymowicz, Tyler Kenning, Carlos D. Pinheiro‐Neto Tags: Allergy/Rhinology Source Type: research

Early introduction of food to prevent food allergy. The LEAP study (Learning Early about Peanut)
Objective: To report a case of a preschool girl who developed acute urinary retention associated with constipation. Case description: A girl aged six years old presented a 24 h history of inability to urinate. She was went twice to the emergency room during this period. In the first admission, 12 h after the onset of the symptoms, she presented abdominal pain and acute urinary retention. After the drainage by urinary catheterization of 300 mL of clear urine, she presented relief of the symptoms and, as urinalysis had no change, the patient was discharged home. Twelve hours after the first visit, she returned to the emergen...
Source: Revista Paulista de Pediatria - December 22, 2015 Category: Pediatrics Source Type: research

Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial
Conclusions The influence of early antirheumatic therapy on ACPA seroreversions was markedly different across specificities, and early disappearance of anti-cVim antibodies associated with better radiological outcome. Thus, these data suggest that the disappearance of particular ACPA reactivities may be beneficial in early RA. Trial registration number WHO database at the Karolinska institute: CT20080004; and clinicaltrials.gov: NCT00764725.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Kastbom, A., Forslind, K., Ernestam, S., Geborek, P., Karlsson, J. A., Petersson, I. F., Saevarsdottir, S., Klareskog, L., van Vollenhoven, R. F., Lundberg, K. Tags: Open access, Immunology (including allergy), Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis Clinical and epidemiological research Source Type: research

Synovitis in knee osteoarthritis: a precursor of disease?
Conclusions Effusion-synovitis and Hoffa-synovitis strongly predicted the development of iROA.
Source: Annals of the Rheumatic Diseases - January 11, 2016 Category: Rheumatology Authors: Atukorala, I., Kwoh, C. K., Guermazi, A., Roemer, F. W., Boudreau, R. M., Hannon, M. J., Hunter, D. J. Tags: Immunology (including allergy), Inflammation, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Clinical diagnostic tests, Radiology (diagnostics), Epidemiology Clinical and epidemiological research Source Type: research

Serum Jo-1 Autoantibody and Isolated Arthritis in the Antisynthetase Syndrome: Review of the Literature and Report of the Experience of AENEAS Collaborative Group
Abstract Anti-Jo-1 is the most frequently detectable antibody in the antisynthetase syndrome (ASSD), an autoimmune disease characterized by the occurrence of arthritis, myositis, and interstitial lung disease (ILD). Recently, we organized an international collaborative group called American and European NEtwork of Antisynthetase Syndrome (AENEAS) for the study of this rare and fascinating disease. The group collected and published one of the largest series of ASSD patients ever described and with one of the longer follow-up ever reported. The number of participating centers is steadily increasing, as well as the a...
Source: Clinical Reviews in Allergy and Immunology - January 19, 2016 Category: Allergy & Immunology Source Type: research

Early introduction of food to prevent food allergy. The LEAP study (Learning Early about Peanut)
Objective: To report a case of a preschool girl who developed acute urinary retention associated with constipation. Case description: A girl aged six years old presented a 24 h history of inability to urinate. She was went twice to the emergency room during this period. In the first admission, 12 h after the onset of the symptoms, she presented abdominal pain and acute urinary retention. After the drainage by urinary catheterization of 300 mL of clear urine, she presented relief of the symptoms and, as urinalysis had no change, the patient was discharged home. Twelve hours after the first visit, she returned to the emergen...
Source: Revista Paulista de Pediatria - January 22, 2016 Category: Pediatrics Source Type: research