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Procedure: Spirometry

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Total 1034 results found since Jan 2013.

Bronchial Asthma and Bronchial Hyperresponsiveness and Their Characteristics in Patients with Common Variable Immunodeficiency
Conclusions: An increased prevalence of BHR and BA was detected in CVID patients compared to the general population. BA may develop despite the disturbed immunoglobulin production, and the majority of patients display nonatopic and noneosinophilic properties. These results suggest a limited role of atopy and eosinophilic inflammation in the pathogenesis of BA in CVID patients.Int Arch Allergy Immunol
Source: International Archives of Allergy and Immunology - November 20, 2018 Category: Allergy & Immunology Source Type: research

Usefulness of portable spirometry in addition to clinical asthma control score (C-ACT) in atopic children before performing an oral food challenge.
Conclusion: We found no systematic association between spirometry and C-ACT before performing OFC. These results imply that both tests may be additional in assessing asthma control. C-ACT may reflect control for the previous month, when spirometry is more informative on the control of asthma the day of OFC.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Jouglet, M., Schweitzer, C., Demoulin-Alexikova, S., Luc, A., Ioan, I., Dumond, P., Divaret-Chauveau, A. Tags: Paediatric asthma and allergy Source Type: research

Particles in exhaled air (PExA) in assessment of asthma in children
Conclusions: Novel PExA method was successfully assessed in healthy and asthmatic children (6-18 years). PExA 2.0 seems to discriminate healthy children from the asthmatics.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Juusela, M., Malmström, K., Aaltonen, V., Sarna, S., Qvist, E. Tags: Paediatric asthma and allergy Source Type: research

Omalizumab Effectiveness by Biomarker Status in Patients with Asthma: Evidence From PROSPERO, A Prospective Real-World Study
ConclusionsOmalizumab initiation in patients with asthma resulted in improved exacerbation rates, reduced hospitalizations, and improved ACT scores compared with pretreatment values, regardless of biomarker status.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 29, 2018 Category: Allergy & Immunology Source Type: research

Lung Lavage Granulocyte Patterns and Clinical Phenotypes in Children with Severe, Therapy-Resistant Asthma
ConclusionsIn children with severe, therapy-resistant asthma, BAL granulocyte patterns and infectious species are associated with novel phenotypic features which can inform pathway-specific revisions in treatment. In 32% of children evaluated, BAL revealed corticosteroid-refractory eosinophilic infiltration amenable to anti-Th2 biological therapies, and in 12%, a treatable bacterial pathogen.
Source: The Journal of Allergy and Clinical Immunology: In Practice - January 15, 2019 Category: Allergy & Immunology Source Type: research

The role of early life food sensitization in adolescent lung function: Results from two birth cohort studies
ConclusionThis study showed that food sensitization at 6 and 12 months was associated with reduced FEV1 in adolescence. Our finding that this link is not completely mediated by either subsequent asthma or aeroallergen sensitization is novel and suggests that early food sensitization itself can be used to identify high-risk groups for poor lung health.
Source: The Journal of Allergy and Clinical Immunology: In Practice - February 12, 2019 Category: Allergy & Immunology Source Type: research

Association Between Pulmonary Function and Asthma Symptoms
ConclusionsThe weak and statistically insignificant association between FEV1%pred and ACQ-5/ACQ-6 scores in unadjusted models suggests a high degree of unexplained variation between these measures. Results support the use of both symptoms and pulmonary function, rather than relying on one measure alone, to assess asthma control in clinical care and outcomes studies.
Source: The Journal of Allergy and Clinical Immunology: In Practice - April 27, 2019 Category: Allergy & Immunology Source Type: research

The Role of Early Life Food Sensitization in Adolescent Lung Function: Results from 2 Birth Cohort Studies
ConclusionsThis study showed that food sensitization at 6 and 12 months was associated with reduced FEV1 in adolescence. Our finding that this link is not completely mediated by either subsequent asthma or aeroallergen sensitization is novel and suggests that early food sensitization itself can be used to identify high-risk groups for poor lung health.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 3, 2019 Category: Allergy & Immunology Source Type: research

Small Airway Dysfunction by Impulse Oscillometry in Symptomatic Patients with Preserved Pulmonary Function
ConclusionPatients with respiratory symptoms and PPF may have SAD that can be identified with the aid of IOS in addition to spirometry.
Source: The Journal of Allergy and Clinical Immunology: In Practice - July 11, 2019 Category: Allergy & Immunology Source Type: research

Diagnostic cut-offs and clinical utility of recombinant Aspergillus fumigatus antigens in the diagnosis of allergic bronchopulmonary aspergillosis
ConclusionIgE against rAsp f1 and f2 (using ROC derived cut-offs) were found to be the most useful in differentiating ABPA from ASA. Due to conduct at single-center, our results require further validation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 11, 2019 Category: Allergy & Immunology Source Type: research

Clinical characteristics of cough frequency patterns in patients with and without asthma
ConclusionsIn asthmatic patients, nocturnal CoFr can be associated with BHR, was significantly higher before treatment, but improved more after treatment compared to non-asthmatic patients. Monitoring nocturnal CoFr may provide unique and valuable information on making an early prediction of therapeutic effects in asthma.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 19, 2019 Category: Allergy & Immunology Source Type: research

Diagnostic Cutoffs and Clinical Utility of Recombinant Aspergillus fumigatus Antigens in the Diagnosis of Allergic Bronchopulmonary Aspergillosis
ConclusionsIgE against rAsp f1 and f2 (using receiver-operating characteristic–derived cutoffs) were found to be the most useful in differentiating ABPA from ASA. Because this study was conducted at a single center, our results require further validation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 2, 2019 Category: Allergy & Immunology Source Type: research

Predicting the response to bronchial thermoplasty
ConclusionThe most severely afflicted patients had the greatest improvements in ACQ, exacerbation frequency and medication requirement.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 9, 2019 Category: Allergy & Immunology Source Type: research

A202 lack of concordance between feno and spirometry in patients with chronic cough
Cough variant asthma (CVA) is a type of asthma in which the main symptom is a dry, non-productive chronic cough (CC) in the absence of wheezing or shortness of breath (Corrao WM. Allergy Asthma Proc. 2018; 39: 466). The condition is frequently underdiagnosed, since baseline spirometric values are usually normal. Since airway inflammation is the basis of CVA, fractional exhaled nitric oxide (FeNO) is often used for patient evaluation but is still open to question. We aimed to explore the value of FeNO measurements in diagnosing patients with CC suspected to have CVA.
Source: Annals of Allergy, Asthma and Immunology - October 31, 2019 Category: Allergy & Immunology Authors: T. Nsouli, N. Diliberto, S. Nsouli, S. Zamora, A. Nsouli, J. Bellanti Source Type: research

Clinical characterization and predictors of IOS-defined small airway dysfunction in asthma.
ConclusionWe identified predictors of SAD and showed that especially EIA, overweight, asthma-related night awakenings, smoking, and older age were strongly associated with SAD.
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 12, 2019 Category: Allergy & Immunology Source Type: research