Omalizumab Effectiveness by Biomarker Status in Patients with Asthma: Evidence From PROSPERO, A Prospective Real-World Study
Publication date: January 2019Source: The Journal of Allergy and Clinical Immunology: In Practice, Volume 7, Issue 1Author(s): Thomas B. Casale, Allan T. Luskin, William Busse, Robert S. Zeiger, Benjamin Trzaskoma, Ming Yang, Noelle M. Griffin, Bradley E. ChippsBackgroundOmalizumab has demonstrated efficacy in clinical trials of patients with asthma, but real-world data are needed.ObjectiveTo assess outcomes after omalizumab initiation in patients with asthma in a real-world setting.MethodsPatients aged 12 years and older with allergic asthma who were candidates for omalizumab on the basis of physician-assessed need were enrolled in a US-based, prospective, single-arm, 48-week multicenter study, the Prospective Observational Study to Evaluate Predictors of Clinical Effectiveness in Response to Omalizumab. Monthly assessments included exacerbations, health care utilization, asthma control test (ACT), and adverse events. At baseline, 6 months, and end of study, biomarkers (blood eosinophils and fractional exhaled nitric oxide) were collected and spirometry performed.ResultsOf 806 enrollees, 801 (99.4%) received omalizumab and 622 (77.2%) completed the study. The exacerbation rate significantly improved from a mean of 3.00 ± 3.28 in the 12 months before baseline to 0.78 ± 1.37 through month 12 (P
ConclusionWhile most PCPs and respiratory/allergy specialists can reach a working diagnosis of ACO, there remains uncertainty around which diagnostic features are most important and what constitutes optimal management. It is imperative that clinical studies including patients with ACO are initiated, allowing the generation of evidence ‐based management strategies.This article is protected by copyright. All rights reserved.
Publication date: Available online 16 February 2019Source: Nitric OxideAuthor(s): M. Bobrowska-Korzeniowska, I. Stelmach, A. Brzozowska, J. Jerzyńska, M. Mitał, W. StelmachAbstractTo date, some studies suggest that passive smoking (PS) may be an important determinant of FeNO levels in children but sill there is a need of investigations using objective methods of PS exposure.The aim of our study was to examine the effect of PS, measured by urine cotinine levels, on FeNO and lung function (FEV1) in allergic and non-allergic asthmatic children.MethodsIt was a prospective, non-interventional study. 140 children, aged 4&ndash...
ConclusionThis study showed that food sensitization at 6 and 12 months was associated with reduced FEV1 in adolescence. Our finding that this link is not completely mediated by either subsequent asthma or aeroallergen sensitization is novel and suggests that early food sensitization itself can be used to identify high-risk groups for poor lung health.
Assessment of lung function is an essential component for understanding lung development. We sought to determine trajectories of lung function in a high-risk, urban longitudinal birth cohort.
Abstract BACKGROUND: Perennial allergic rhinitis (PAR) often coexists in asthmatic patients. Intranasal cellulose powder (ICP) was reportedly effective in ameliorating PAR. OBJECTIVE: We investigated whether ICP is equally effective compared with intranasal corticosteroids in improving asthma control as well as nasal symptoms among children with PAR and allergic asthma (AA). METHODS: Between July 2015 and September 2016, we did a single-center, randomized, placebo-controlled trial. Asthmatic children aged 6 to 11 years with mild-to-moderate PAR were randomly assigned to formoterol/budesonide inhalation (...
The decline in lung function is observed among asthma and obesity. Measurement of obstructive airway by spirometry is suggested to confirm the diagnosis and monitor treatment outcomes in asthma. Nevertheless, spirometry is hard to complete in preschooler. Impulse oscillometry (IOS) is a new and easier technique to measure airway resistance. We aim to evaluate IOS parameter in Thai asthmatic patients and Thai obese children.
Bronchial asthma is a chronic inflammatory lung disease characterized by variable airflow limitation and underlying inflammation. Impulse oscillometry (IOS) has been to measure small airways function, but limited data are available that corelate the bronchodilator response using spirometry and IOS in asthmatic children.
This study is to be determined if methacholine challenge test could be replaced by FeNO.
Forced oscillation technique (FOT) has a potential to evaluate respiratory pathophysiology in asthma that spirometry does not detect. Since lung function decline in children with asthma has been reported to have significant impact on development of COPD in later life, we investigated changes in FOT parameters in children/adolescents with asthma in relation with changes in maximal expiratory flow at 50 % of the forced vital capacity (MEF50), an index for the small airways.
CONCLUSION: The patients with chronic cough frequently had paranasal sinus abnormalities. The Lund-Mackay CT score may be useful for assessing the condition of the lower airway in chronic cough patients. Upper airway examinations should play a part in the management of chronic cough. PMID: 30656950 [PubMed - as supplied by publisher]