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Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation
Biochem Biophys Res Commun. 2021 Dec 1;587:99-106. doi: 10.1016/j.bbrc.2021.11.101. Online ahead of print.ABSTRACTColorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of auriculasin in promoting ROS generation and inhibiting cell viability were blocked. Auriculasin induced CRC cell apopto...
Source: Biochemical and Biophysical Research communications - December 6, 2021 Category: Biochemistry Authors: Chun-Xiao Wang Li-Hua Chen Hai-Bin Zhuang Ze-Sheng Shi Zhi Chuan Chen Jian-Peng Pan Zhong-Shi Hong Source Type: research

Resveratrol activates PI3K/AKT to reduce myocardial cell apoptosis and mitochondrial oxidative damage caused by myocardial ischemia/reperfusion injury
In conclusion, our study shows that resveratrol can reduce ROS in cardiomyocytes by PI3K/AKT signaling pathway activation, and effectively inhibit the apoptosis of cardiomyocytes, thus having a direct protective effect on cardiomyocytes under SR.PMID:34107386 | DOI:10.1016/j.acthis.2021.151739
Source: Acta Histochemica - June 9, 2021 Category: Biochemistry Authors: Dongmin Yu Jianxian Xiong Yizhou Gao Jinghang Li Dawei Zhu Xiaowei Shen Lifu Sun Xiaowei Wang Source Type: research

7‐Methoxy‐(9H‐β‐Carbolin‐1‐Il)‐(E)‐2‐Propenoic Acid, a β‐Carboline Alkaloid from Eurycoma Longifolia, Exhibits Anti‐Inflammatory Effects by Activating the Nrf2/Heme Oxygenase‐1 Pathway
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - August 21, 2015 Category: Biochemistry Authors: Nguyen Hai Dang, Young‐Yeon Choo, Nguyen Tien Dat, Nguyen Hoai Nam, Chau Van Minh, Jeong‐Hyung Lee Tags: Article Source Type: research

7‐Methoxy‐(9H‐β‐Carbolin‐1‐il)‐(E)‐1‐Propenoic Acid, a β‐Carboline Alkaloid From Eurycoma longifolia, Exhibits Anti‐Inflammatory Effects by Activating the Nrf2/Heme Oxygenase‐1 Pathway
ABSTRACT Eurycoma longifolia is an herbal medicinal plant popularly used in Southeast Asian countries. In the present study, we show that 7‐methoxy‐(9H‐β‐carbolin‐1‐il)‐(E)‐1‐propenoic acid (7‐MCPA), a β‐carboline alkaloid isolated from E. longifolia, exerted anti‐inflammatory effects by activating the nuclear factor‐E2‐related factor 2 (Nrf2)/heme oxygenase‐1 (HO‐1) pathway. 7‐MCPA inhibited lipopolysaccharide (LPS)‐induced production of nitric oxide (NO), prostaglandin E2 (PGE2), and interleukin‐6 (IL‐6) in RAW264.7 cells and rescued C57BL/6 mice from LPS‐induced lethality in v...
Source: Journal of Cellular Biochemistry - September 3, 2015 Category: Biochemistry Authors: Nguyen Hai Dang, Young‐Yeon Choo, Nguyen Tien Dat, Nguyen Hoai Nam, Chau Van Minh, Jeong‐Hyung Lee Tags: Article Source Type: research

Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells
Fitoterapia. 2021 Oct 19:105066. doi: 10.1016/j.fitote.2021.105066. Online ahead of print.ABSTRACTLewy bodies are characteristic spherical inclusions in Parkinson's disease (PD) that are formed by α-synuclein fibrils. Ferruginol (Fer) is an amonomeric compound isolated from a traditional Chinese herb. Here, we show that Fer exerted potent neuroprotective effects in both in vitro and in vivo PD models. Neuronal cells transfected with A53T mutant (A53T) α-synuclein plasmids and treated with Fer exhibited attenuated the cytotoxicity induced by pathogenic A53T α-synuclein overexpression. Further, when we transfected neurona...
Source: Fitoterapia - October 22, 2021 Category: Biochemistry Authors: Xiaohong Wang Guiyun Cao Dongyi Ding Fei Li Xuesong Zhao Jiahua Wang Yang Yang Source Type: research

Promotion of ABCG2 gene expression by neolignans from Piper longum L
Biosci Biotechnol Biochem. 2023 Sep 14:zbad132. doi: 10.1093/bbb/zbad132. Online ahead of print.ABSTRACTWe focused on Piper longum L., an herbal drug produced in Myanmar, which has a renoprotective effect. Thus, we attempted to isolate and identify compounds that enhance the expression of the ABCG2 gene from the aerial parts of the plant except for the fruit. Among the various P. longum extracts, we isolated and identified the components. Using Caco-2 cells, the hABCG2 mRNA expression-enhancing effects of the isolated compounds were compared with the positive reference compound (3-methylcholanthrene: 3MC) using real-time P...
Source: Bioscience, Biotechnology, and Biochemistry - September 14, 2023 Category: Biochemistry Authors: Atsuyoshi Nishina Motohiko Ukiya Kazuki Motegi Risa Kiryu Daisuke Sato Mitsuru Sada Yuki Hori Hideo Satsu Kazuhiro Uemura Mamoru Koketsu Masayuki Ninomiya Lwin Mon Mon Myint Hirokazu Kimura Source Type: research