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The role of zinc sulfate in enhancing cellular and humoral immune responses to foot-and-mouth disease vaccine
Virus Res. 2023 Aug 1:199189. doi: 10.1016/j.virusres.2023.199189. Online ahead of print.ABSTRACTFoot-and-mouth disease (FMD) is a rapidly propagating infectious disease of cloven-hoofed animals, especially cattle and pigs, affecting the productivity and profitability of the livestock industry. Presently, FMD is controlled and prevented using vaccines; however, conventional FMD vaccines have several disadvantages, including short vaccine efficacy, low antibody titers, and safety issues in pigs, indicating the need for further studies. Here, we evaluated the efficacy of a novel bivalent vaccine containing zinc sulfate as an...
Source: Virus Research - August 3, 2023 Category: Virology Authors: Mi-Kyeong Ko Hyeong Won Kim So Hui Park Jong-Hyeon Park Su-Mi Kim Min Ja Lee Source Type: research

Type-I like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of nov...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Type I-like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29;229:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Type-I like metalloproteinase in the venom of the West African saw-scaled carpet viper (Echis ocellatus) has anti-trypanosomal activity against African trypanosomes
Toxicon. 2023 Apr 29:107138. doi: 10.1016/j.toxicon.2023.107138. Online ahead of print.ABSTRACTAfrican trypanosomiasis is an infectious disease caused by hemoparasites of the genus Trypanosoma and remains a major health problem in Africa - killing around 4000 people and animals worth an estimated $5 billion, annually. The absence of a vaccine and satisfactory drug against African trypanosomiasis (AT) necessitates the continued search for new chemotherapy options. Owing to the rich biochemical diversity in snake venom, it has recently become a source of therapeutic peptides that are being explored for the development of nov...
Source: Toxicon - May 1, 2023 Category: Toxicology Authors: Ameh Ilu Mathias A Chia Thais R Cataldi Carlos A Labate Godwin U Ebiloma Peter O Yusuf Mohammed N Shuaibu Emmanuel O Balogun Source Type: research

Diagnostic Value of Circulating Antigens in the Serum of Piglets with Experimental Acute Toxoplasmosis
In this study, we established a model of acute T. gondii infection in Large White pigs. CAg levels peaked between 3 and 5 d after inoculation, and 28 CAgs were identified using an immunoprecipitation-shotgun approach, among which dolichol-phosphate-mannose synthase family protein (TgDPM), C3HC zinc finger-like protein (TgZFLP3), and ribosomal protein RPL7 (TgRPL7) were selected to further investigate their value in the diagnosis of acute toxoplasmosis. Immunofluorescence assays revealed that TgDPM and TgRPL7 were localized in the membrane surface, while TgZFLP3 was localized in the apical end. Western blotting revealed the...
Source: Journal of Immunology - January 13, 2022 Category: Allergy & Immunology Authors: Qi Liu Man-Yu Zhang Bing Zhao Yun Chen Wei Jiang Xiao-Ling Geng Quan Wang Source Type: research

A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression
Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research