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a case of eosinophilic gastroenteritis found by pica during oral immunotherapy.
We report the case of a 6-year-old boy with EGE. He was diagnosed as having immediate-type food allergies (egg, milk and wheat) by oral food challenges at 1 year of age. OIT for each food was carried out, and the amounts of the offending foods were able to be gradually increased without causing any immediate-type allergy symptoms. However, the total IgE and specific IgE values were remarkably increased at the age of 4 years and 4 months. He first developed oral mucosa symptoms and vomiting at 4 years and 10 months of age, and they gradually worsened. Stopping eggs and milk alleviated the symptoms. Nevertheless, he still oc...
Source: Arerugi - March 20, 2020 Category: Allergy & Immunology Authors: Nishimura K, Fukuie T, Miyaji Y, Inuzuka Y, Toyokuni K, Irahara M, Ishikawa F, Sato M, Saito M, Yamamoto-Hanada K, Narita M, Nomura I, Ohya Y Tags: Arerugi Source Type: research

Treatment of eosinophilic esophagitis with diets: an update.
Authors: Lucendo AJ, Molina-Infante J Abstract Eosinophilic esophagitis (EoE) is a chronic inflammatory esophageal disease triggered and maintained predominantly by food antigens. It represents a unique form of non-IgE mediated food allergy, largely dependent upon delayed, cell-mediated hypersensitivity. First-line therapies for EoE consist on drugs with anti-inflammatory effect (mainly including topic steroids and proton pump inhibitors) and dietary therapy. An elimination diet that avoids the consumption of food triggers currently remains the only therapy targeting the cause of EoE. Currently, available food alle...
Source: Minerva Gastroenterologica e Dietologica - November 27, 2019 Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research

Eosinophilic esophagitis: Pathophysiology, diagnosis, and management.
Abstract Eosinophilic esophagitis (EoE) is a multifactorial esophageal inflammation, with a genetic predisposition, which combines a deficient esophageal mucosal barrier, an abnormal immune reaction to environmental allergens mediated by Th2 interleukins, immediate esophageal lesions and dysmotility, with secondary remodeling and fibrosis. Symptoms include reflux, abdominal pain, and food impaction, with a variation according to age. Fibroscopy shows major and minor endoscopic and histologic criteria, with a mucosal count≥15 eosinophils/high power field (Eo/hpf). A new entity has been defined, where gastroesopha...
Source: Archives de Pediatrie - February 27, 2019 Category: Pediatrics Authors: Vinit C, Dieme A, Courbage S, Dehaine C, Dufeu CM, Jacquemot S, Lajus M, Montigny L, Payen E, Yang DD, Dupont C Tags: Arch Pediatr Source Type: research

Dietary therapy for eosinophilic esophagitis
Eosinophilic esophagitis is a chronic, immune-mediated esophageal disease triggered predominantly, but not exclusively, by food antigens. Presently, available food allergy tests are suboptimal to predict food triggers for eosinophilic esophagitis, especially in adults. Elemental diets (exclusive feeding with amino acid –based formulas) and empiric 6-food elimination diets (withdrawing milk, wheat, egg, soy, nuts, and fish/seafood for 6 weeks) have consistently shown the best efficacy rates. However, their high level of restriction and need for multiple endoscopies have hampered their implementation in clinical practice.
Source: Journal of Allergy and Clinical Immunology - March 6, 2018 Category: Allergy & Immunology Authors: Javier Molina-Infante, Alfredo J. Lucendo Tags: Current perspectives Source Type: research

Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: The 2-4-6 study
Numerous dietary restrictions and endoscopies limit the implementation of empiric elimination diets in patients with eosinophilic esophagitis (EoE). Milk and wheat/gluten are the most common food triggers.
Source: Journal of Allergy and Clinical Immunology - October 23, 2017 Category: Allergy & Immunology Authors: Javier Molina-Infante, Ángel Arias, Javier Alcedo, Ruth Garcia-Romero, Sergio Casabona-Frances, Alicia Prieto-Garcia, Ines Modolell, Pedro L. Gonzalez-Cordero, Isabel Perez-Martinez, Jose Luis Martin-Lorente, Carlos Guarner-Argente, Maria L. Masiques, Vi Tags: Food allergy and gastrointestinal disease Source Type: research

IgE-Mediated allergy to wheat in a child with celiac disease ¿ a case report
Conclusion: To our knowledge, this is the first report of a patient with celiac disease and concomitant IgE-mediated allergy to wheat presenting with immediate symptoms in two body systems. Although the pathophysiology of these diseases is different, this case demonstrates that they are not exclusive of one another. In patients who develop unexplained symptoms consistent with IgE-mediated allergy, an allergy assessment should be considered.
Source: Allergy, Asthma and Clinical Immunology - November 10, 2014 Category: Allergy & Immunology Authors: Tiffany WongHin KoEdmond Chan Source Type: research