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Impact of postnatal steroids on peripheral avascular retina and severity of retinopathy of prematurity
CONCLUSION: Cumulative dose and duration of postnatal steroid use were independently associated with the severity of ROP and PAR. Thus, postnatal steroids should be used very prudently.IMPACT: We report ROP outcomes in a large cohort of infants from two major healthcare systems where we have studied the impact of postnatal steroids on the severity of ROP, growth, and development of retinal vessels. After correcting our data for three major outcome measures, we show that high-dose postnatal steroids used for a prolonged duration of time are independently associated with severe ROP and delay in retinal vascularization. Postn...
Source: Pediatric Research - June 8, 2023 Category: Pediatrics Authors: Prem S Shekhawat Mahmoud A M Ali Naveen Kannekanti Hannah Koechley Christiane Mhanna Merlin Pinto Mohsen A A Farghaly Maroun Mhanna Hany Z Aly Jonathan E Sears Source Type: research

Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure
CONCLUSIONS: The currently available evidence on the effectiveness of adjunctive steroid therapy versus antibiotics alone in the management of acute endophthalmitis after intraocular surgery is inadequate. We found no studies that had enrolled cases of acute endophthalmitis following intravitreous injection. A combined analysis of two studies suggests that use of adjunctive steroids may provide a higher chance of having a good visual outcome at three months than not using adjunctive steroids. However, considering that most of the confidence intervals crossed the null, and that this review was limited in scope and applicabi...
Source: Cochrane Database of Systematic Reviews - June 6, 2022 Category: General Medicine Authors: Sara Emami Ken Kitayama Anne L Coleman Source Type: research

Case Report: Herpes Simplex Virus Type 2 Acute Retinal Necrosis With Viral Encephalitis in Children
CONCLUSION: HSV-2-related pediatric acute retinal necrosis may be due to the acquisition of subclinical infection with HSV-2 during parturition, followed by reactivation of the virus latent in the body on account of certain factors. Moreover, it may be complicated with viral encephalitis. For suspected cases with invisible fundus, early intraocular fluid examination is especially helpful for differential diagnosis. Early diagnosis, early treatment, and timely prophylactic laser treatment to prevent retinal detachment are key to a better prognosis. Physicians need to pay attention to such suspected cases during diagnosis an...
Source: Herpes - April 4, 2022 Category: Infectious Diseases Authors: Luyao He Jialiang Duan Qingli Shang Source Type: research

Evaluation of the neuroprotective effects of methylprednisolone and surgical decompression in a rodent model of traumatic optic neuropathy
CONCLUSIONS: The present model revealed significant neuroprotective effects following administration of methylprednisolone for TON treatment. Mitigation of neuronal loss may result in functional benefits. Neuroprotective effects were not observed following surgical therapy, suggesting that this approach should be reserved for individual cases such as hematomas in the area of nerve envelopes.PMID:34696640 | DOI:10.1080/02713683.2021.1998544
Source: Current Eye Research - October 26, 2021 Category: Opthalmology Authors: Philippe Korn Nils-Claudius Gellrich Simon Spalthoff Philipp Jehn Ulf T Eysel Martin Zerfowski Source Type: research

Sympathetic Ophthalmia - a Contribution to Immunology, Clinic and Current Imaging.
CONCLUSION: SO remains a threatening clinical diagnosis that poses diagnostic and therapeutic challenges. It can be triggered post-traumatic, but also any intraocular surgery. This should be taken into account when assessing the indication for intraocular eye surgery, especially in eyes with reduced visual outcome. PMID: 32967030 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - September 24, 2020 Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research