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Total 327 results found since Jan 2013.
7-Methylxanthine Influences the Behavior of ADORA2A-DRD2 Heterodimers in Human Retinal Pigment Epithelial Cells
CONCLUSIONS: ADORA2A and DRD2 heterodimers were present in RPE cells. 7-MX may affect the behaviors of RPE cells through the ADORA2A-DRD2 receptor pathway. 7-MX is an inhibitor of ADORA2A receptors that can prevent inhibition of the D2 receptor pathway and increase D2 receptor pathway activity. This phenomenon may explain the mechanism of action through which 7-MX can control myopia progression.PMID:35724635 | DOI:10.1159/000525563
Source: Cell Research - June 20, 2022 Category: Cytology Authors: Yuzhuo Fan Jiarui Li Lvzhen Huang Kai Wang Mingwei Zhao Source Type: research
Inhibition of CD146 lessens uveal melanoma progression through reducing angiogenesis and vasculogenic mimicry
ConclusionsCD146 is a novel mediator of both angiogenesis and vasculogenic mimicry in uveal melanoma. Its antibody AA98 has the potency to be developed as a new antibody drug for treating uveal melanoma. Our results warrant further assessment of CD146 as a potential target to improve therapeutic management of uveal melanoma in a clinical setting.
Source: Cellular Oncology - June 18, 2022 Category: Cancer & Oncology Source Type: research
Expression and activation of the ketone body receptor HCAR2/GPR109A promotes preservation of retinal endothelial cell barrier function
Exp Eye Res. 2022 May 29:109129. doi: 10.1016/j.exer.2022.109129. Online ahead of print.ABSTRACTPreservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it is not surprising that loss of barrier integrity is a pathologic feature common to degenerative retinal diseases such as diabetic retinopathy. Our prior studies demonstrate the importance of hydroxycarboxylic acid receptor 2/GPR109A (HCAR2/GPR109A) expression in the retinal pigment epithelium (RPE) to outer retinal barrier integrity. However, whether HCAR2/GPR109A is expressed in retinal endothelial cells and has a similar relati...
Source: Experimental Eye Research - June 1, 2022 Category: Opthalmology Authors: Ammar A Abdelrahman Folami L Powell Ravirajsinh N Jadeja Malita A Jones Menaka C Thounaojam Manuela Bartoli Mohamed Al-Shabrawey Pamela M Martin Source Type: research
Agonism of GPR120 Prevented High Glucose-Induced Apoptosis of Retinal Endothelial Cells through Inhibiting NLRP3 Inflammasome
CONCLUSIONS: Activation of GPR120 protects retinal vascular endothelial cells from HG through inhibiting NLRP3 inflammasome. Thus, GPR120 might be a potential therapeutic target to reduce retinal endothelial damage in diabetic retinopathy.PMID:35584771 | DOI:10.1055/a-1811-7099
Source: Klinische Monatsblatter fur Augenheilkunde - May 18, 2022 Category: Opthalmology Authors: Xiaoju Ding Haijuan Xie Wuqiang Shan Ligang Li Source Type: research
Protective effect of pentraxin 3 on pathological retinal angiogenesis in an in vitro model of diabetic retinopathy
CONCLUSIONS: The upregulated expression of PTX3 may play a protective role on pathological angiogenesis in DR. PTX3 may serve as a new target for the treatment of DR.PMID:35577071 | DOI:10.1016/j.abb.2022.109283
Source: Archives of Biochemistry and Biophysics - May 16, 2022 Category: Biochemistry Authors: Yan Jiang Xindan Xing Tian Niu Hanying Wang Chingyi Wang Xin Shi Kun Liu Li Su Source Type: research
TNFAIP3 may be key to TLR4-activation of the inflammasome in the retinal vasculature
Exp Eye Res. 2022 May 11:109108. doi: 10.1016/j.exer.2022.109108. Online ahead of print.ABSTRACTThe goal of these studies were to determine whether tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) regulated toll-like receptor 4 (TLR4) actions on the NOD-like receptor protein 3 (NLRP3) inflammasome. Western blotting was done on retinal lysates from TLR4 floxed and endothelial cell specific TLR4 knockout mice for TNFAIP3, TLR4, and NLRP3 pathway proteins. Retinal endothelial cells (REC) were grown in normal (5mM) and high glucose (25mM) and treated with TNFAIP3 siRNA, followed by Western blotting for TLR4 and NLRP3 p...
Source: Experimental Eye Research - May 14, 2022 Category: Opthalmology Authors: Li Liu Youde Jiang Jena J Steinle Source Type: research
