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Food Allergy History and Reaction to Propofol Administration in a Large Pediatric Population.
CONCLUSIONS: In the listed food-allergic cohort, the majority had no allergy testing or negative testing. We found no evidence of a relationship between food allergy history and perioperative propofol reaction. We suggest multiply allergic and atopic patients may have a similar likelihood of propofol reaction as with other medications. PMID: 33529424 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - February 2, 2021 Category: Anesthesiology Authors: Bagley L, Kordun A, Sinnott S, Lobo K, Cravero J Tags: Paediatr Anaesth Source Type: research

Sex Differences in IL-33-Induced STAT6-Dependent Type 2 Airway Inflammation
In this study, we have demonstrated that delivery of OVA+IL-33 to the lungs of mice induced an innate inflammatory response that exhibited sex-dependent differences in magnitude and regulation. Compared to males, female mice produced larger amounts of type 2 cytokines and chemokines and had substantially more activated eosinophils and AAM in the lung; each of these responses was significantly lower in female mice lacking STAT6. On the contrary, male mice displayed less inflammation overall, and in some instances, no apparent role for STAT6 was observed. BALF levels of inflammatory mediators and eosinophils were very lo...
Source: Frontiers in Immunology - April 30, 2019 Category: Allergy & Immunology Source Type: research

Sequential Immunization With Live-Attenuated Chimeric Hemagglutinin-Based Vaccines Confers Heterosubtypic Immunity Against Influenza A Viruses in a Preclinical Ferret Model
This study was also partly funded by a research contract from GSK. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the funders. Conflict of Interest Statement AG-S, FK, and PP are inventors in patent applications filed and owned b
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Allergy alerts - the incidence of parentally reported allergies in children presenting for general anaesthesia.
CONCLUSION: Only the minority of parent-reported allergies in paediatric surgical patients were specialist confirmed and likely to be clinically relevant. Self-reported food allergy is commonly specialist verified, reactions to medications were generally not. Over-reporting of allergies is increasingly common and limits clinician choice of medications. Better education of patients and their families and more timely verification or dismissal of parent-reported reactions is urgently needed. This article is protected by copyright. All rights reserved. PMID: 30414337 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - November 10, 2018 Category: Anesthesiology Authors: Sommerfield DL, Sommerfield A, Schilling A, Slevin L, Lucas M, von Ungern-Sternberg BS Tags: Paediatr Anaesth Source Type: research

Allergy alerts ‐ the incidence of parentally reported allergies in children presenting for general anaesthesia
ConclusionOnly the minority of parent ‐reported allergies in paediatric surgical patients were specialist confirmed and likely to be clinically relevant. Self‐reported food allergy is commonly specialist verified, reactions to medications were generally not. Over‐reporting of allergies is increasingly common and limits clinician c hoice of medications. Better education of patients and their families and more timely verification or dismissal of parent‐reported reactions is urgently needed.This article is protected by copyright. All rights reserved.
Source: Pediatric Anesthesia - November 10, 2018 Category: Anesthesiology Authors: David L Sommerfield, Aine Sommerfield, Alina Schilling, Lliana Slevin, Michaela Lucas, Britta S von Ungern ‐Sternberg Tags: Research Report Source Type: research

No evidence for contraindications to the use of propofol in adults allergic to egg, soy or peanut
Conclusion. No connection between allergy to propofol and allergy to egg, soy or peanut was found. The present practice of choosing alternatives to propofol in patients with this kind of food allergy is not evidence based and should be reconsidered.
Source: British Journal of Anaesthesia - December 16, 2015 Category: Anesthesiology Authors: Asserhoj, L. L., Mosbech, H., Kroigaard, M., Garvey, L. H. Tags: Clinical Practice Source Type: research

Propofol administration is safe in adult eosinophilic esophagitis patients sensitized to egg, soy, or peanut
ConclusionsPropofol was safely administered for procedural sedation in a large series of adult EoE patients multisensitized to egg, soy, peanut, showing one‐third clinical allergy to these foods.
Source: Allergy - January 21, 2014 Category: Allergy & Immunology Authors: J. Molina‐Infante, A. Arias, D. Vara‐Brenes, R. Prados‐Manzano, J. Gonzalez‐Cervera, M. Alvarado‐Arenas, A. J. Lucendo Tags: Original Article Source Type: research