Allergy alerts ‐ the incidence of parentally reported allergies in children presenting for general anaesthesia

ConclusionOnly the minority of parent ‐reported allergies in paediatric surgical patients were specialist confirmed and likely to be clinically relevant. Self‐reported food allergy is commonly specialist verified, reactions to medications were generally not. Over‐reporting of allergies is increasingly common and limits clinician c hoice of medications. Better education of patients and their families and more timely verification or dismissal of parent‐reported reactions is urgently needed.This article is protected by copyright. All rights reserved.
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: Research Report Source Type: research

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Abstract Childhood allergy is common, and increasing. Many children are incorrectly labeled as having allergy or adverse drug reactions. This can pose a dilemma for anesthetists and lead to a change in practice or drug selection. We review the pathophysiology of hypersensitivity reactions and the implications for anesthesia of food allergy, atopy, and family history of allergy in children. The epidemiology of anaphylaxis is discussed. We discuss the common triggers of perioperative anaphylaxis in children and explore emerging triggers including chlorhexidine and sugammadex. Accurate data on pediatric perioperative...
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research
In conclusion, our findings identify ALCAM as a novel therapeutic target for preventing corneal allograft rejection in high-risk patient populations. Moreover, given the documented contribution of ALCAM to (lymph)angiogenesis, DC migration, and T cell activation, ALCAM blockade might represent a therapeutic strategy for treating other immune-mediated inflammatory conditions, such as solid organ transplant rejection, allergy or autoimmune diseases. Experimental Procedures Cloning, Expression, and Purification of I/F8-Fc and KSF-Fc For cloning of I/F8-Fc and KSF-Fc the respective scFv sequence was amplified from previousl...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
CONCLUSION: Only the minority of parent-reported allergies in paediatric surgical patients were specialist confirmed and likely to be clinically relevant. Self-reported food allergy is commonly specialist verified, reactions to medications were generally not. Over-reporting of allergies is increasingly common and limits clinician choice of medications. Better education of patients and their families and more timely verification or dismissal of parent-reported reactions is urgently needed. This article is protected by copyright. All rights reserved. PMID: 30414337 [PubMed - as supplied by publisher]
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research
We report a case of anaphylaxis to propofol in an adult patient without food allergy to soy, but with a latent sensitization to soy. An IgE-dependent allergy to propofol was established by a basophil activation test. Here, we document for the first time the existence of specific IgEs to a 65kDa protein, found in soybean oil and soy flour. In the absence of data on the reactogenic threshold for allergenic food proteins injected intravenously, a risk appears to be established and leads us to recommend a systematic detection for proteins in the refined soybean oil used in the pharmaceutical industry for intravenous products. ...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
Publication date: September–October 2017 Source:The Journal of Allergy and Clinical Immunology: In Practice, Volume 5, Issue 5 Author(s): Paul J. Turner, Elina Jerschow, Thisanayagam Umasunthar, Robert Lin, Dianne E. Campbell, Robert J. Boyle Up to 5% of the US population has suffered anaphylaxis. Fatal outcome is rare, such that even for people with known venom or food allergy, fatal anaphylaxis constitutes less than 1% of total mortality risk. The incidence of fatal anaphylaxis has not increased in line with hospital admissions for anaphylaxis. Fatal drug anaphylaxis may be increasing, but rates of fatal anaphylax...
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
ABSTRACT: Propofol is a safe, well-tolerated anesthetic that is labeled as contraindicated in patients with egg or soy allergy. This contraindication has become increasingly problematic given the rising incidence of food allergy and eosinophilic esophagitis (EoE). To address this issue, we studied practice patterns of propofol use for esophagogastroduodenoscopies in children with EoE and food allergies at our institution. A retrospective observational study of 1365 esophagogastroduodenoscopies from January 2013 to June 2014 was performed. Data were analyzed using Student t tests, chi square tests, Fisher exact tests, and m...
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research
Summary Patients with a history of food allergy and food intolerance are common in the pediatric population and are encountered frequently in the perioperative setting by pediatric anesthesiologists. Perioperatively, food allergy can present on a spectrum ranging from minor acute urticaria to more severe hypovolemia and anaphylactic shock. Allergy to foods including fruits, fish, egg, soy, and peanut are most concerning for their potential to cross‐react with perioperative medications. There is little in the anesthesia literature that focuses on the perioperative management of children with food allergies. This education...
Source: Pediatric Anesthesia - Category: Anesthesiology Authors: Tags: Educational Review (Non Commissioned) Source Type: research
Conclusion After watching their son get buried, Cash’s parents were thrown into a world they didn’t know much about. They were now another set of grieving parents who senselessly lost their child due to medical practices recommended under a doctor’s care. Vaccines are being ignored when compiling infant mortality data. In 2013, Cash Dewayne Thomas was one of 23,440 babies who died in the United States before reaching their first birthday, according to the latest infant mortality data published in 2016. [19] About 11,300 newborns die within their first day of life, many soon after receiving their first hep...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Augustina Ursino Human Top Stories apnea Cash Dewayne Thomas Jesse Dewayne Thomas newborn vaccines truth about vaccines Vaccine Death Whitney Hill Source Type: blogs
Anaphylaxis is increasingly common. The patient population death rate for anaphylaxis is Australia in 2013 was over double that reported in the UK Dr Ray Mullins, an allergist in Canberra, and colleagues from Sydney and Singapore have recently reported an increase in in the number of anaphylaxis fatalities in Australia. This is currently trending towards a 3 fold increase in anaphylaxis deaths over the study period of 15 years. Mullins and colleagues had previously identified a rise in the rate of all food allergy, with the most dramatic effect in young childhood food where hospital admission analyses showed a 50...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Research Education Immunology allergy Anaphylaxis EpiPen mastocytosis Ray Mullins Source Type: blogs
We report a case of anaphylaxis to propofol in an adult patient without food allergy to soy, but with a latent sensitization to soy. An IgE-dependent allergy to propofol was established by a basophil activation test. Here, we document for the first time the existence of specific IgEs to a 65kDa protein, found in soybean oil and soy flour. In the absence of data on the reactogenic threshold for allergenic food proteins injected intravenously, a risk appears to be established and leads us to recommend a systematic detection for proteins in the refined soybean oil used in the pharmaceutical industry for intravenous products. ...
Source: European Annals of Allergy and Clinical Immunology - Category: Allergy & Immunology Tags: Eur Ann Allergy Clin Immunol Source Type: research
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