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Total 5 results found since Jan 2013.
The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes.
In conclusion, ellagic acid is an effective skin-whitening agent and might be used as a topical applicant.
PMID: 33545118 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - February 2, 2021 Category: Drugs & Pharmacology Authors: Yang HL, Lin CP, Vudhya Gowrisankar Y, Huang PJ, Chang WL, Shrestha S, Hseu YC Tags: Biochem Pharmacol Source Type: research
Arecoline suppresses epithelial cell viability by upregulating tropomyosin-1 through the transforming growth factor- β/Smad pathway.
CONCLUSIONS: Arecoline suppresses HaCaT cell viability by upregulating TPM1 through the TGF-β/Smad signalling pathway. This research provides a scientific basis for further study of arecoline and TPM1 in OSF and can be generalised to broader pharmacological studies. TPM1 may be a promising molecular target for treating OSF.
PMID: 33332205 [PubMed - in process]
Source: Pharmaceutical Biology - December 19, 2020 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Gut Bacterial Metabolite Urolithin A Decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary UA in cancer prevention or as adjuvant therapy is promising.
Source: Molecular Nutrition and Food Research - February 17, 2020 Category: Food Science Authors: Md Alauddin,
Toshiyuki Okumura,
Janet Rajaxavier,
Shayan Khozooei,
Simone P öschel,
Satoru Takeda,
Yogesh Singh,
Sara Y Brucker,
Diethelm Wallwiener,
André Koch,
Madhuri S Salker Tags: Research Article Source Type: research
Gut metabolite, Urolithin A decreases Actin Polymerization and Migration in Cancer Cells
ConclusionUrolithin A leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization and migration. Thus, use of dietary Urolithin A in cancer prevention or as adjuvant therapy is promising.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - January 23, 2020 Category: Food Science Authors: Md Alauddin,
Toshiyuki Okumura,
Janet Rajaxavier,
Shayan Khozooei,
Simone P öschel,
Satoru Takeda,
Yogesh Singh,
Sara Y Brucker,
Diethelm Wallwiener,
André Koch1,
Madhuri S Salker Tags: Research Article Source Type: research
Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion
This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
