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Total 567 results found since Jan 2013.
Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation
In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe-/- mice were fed with an atherosclerotic Western diet for 8 or 16 weeks. We showed that Par3L expression was significantly increased in human and mouse atherosclerotic plaques. In primary mouse macrophages, oxidized low-density lipoprotein (oxLDL, 50 μg/mL) time-dependently increased Par3L expression. In Apoe-/- mice, adenovirus-mediated Par3L overexpression aggravated atherosclerotic plaque formation accompanied by increased M1 macrophages in atherosclerotic plaques and bo...
Source: Acta Pharmacologica Sinica - September 21, 2023 Category: Drugs & Pharmacology Authors: Yi-Min Huang Yu-Sen Wu Yuan-Ye Dang Yi-Ming Xu Kong-Yang Ma Xiao-Yan Dai Source Type: research
Nutrient-driven dedifferentiation of enteroendocrine cells promotes adaptive intestinal growth in Drosophila
Dev Cell. 2023 Sep 1:S1534-5807(23)00437-9. doi: 10.1016/j.devcel.2023.08.022. Online ahead of print.ABSTRACTPost-developmental organ resizing improves organismal fitness under constantly changing nutrient environments. Although stem cell abundance is a fundamental determinant of adaptive resizing, our understanding of its underlying mechanisms remains primarily limited to the regulation of stem cell division. Here, we demonstrate that nutrient fluctuation induces dedifferentiation in the Drosophila adult midgut to drive adaptive intestinal growth. From lineage tracing and single-cell RNA sequencing, we identify a subpopul...
Source: Developmental Cell - September 9, 2023 Category: Cytology Authors: Hiroki Nagai Luis Augusto Eijy Nagai Sohei Tasaki Ryuichiro Nakato Daiki Umetsu Erina Kuranaga Masayuki Miura Yuichiro Nakajima Source Type: research
Low-dose of polystyrene microplastics induce cardiotoxicity in mice and human-originated cardiac organoids
Environ Int. 2023 Aug 25;179:108171. doi: 10.1016/j.envint.2023.108171. Online ahead of print.ABSTRACTMicroplastic particles (MP) are prevalent in both industrial production and the natural environment, posing a significant concern for human health. Daily diet, air inhalation, and skin contact are major routines of MP intake in human. The main injury target systems of MPs include the digestive system, respiratory system, and cardiovascular system. However, the study on MPs' adverse effects on the heart is less than other target organs. Previous in vivo studies have demonstrated that MPs can induce heart injuries, including...
Source: Environment International - September 5, 2023 Category: Environmental Health Authors: Yue Zhou Qian Wu Yan Li Yan Feng Yan Wang Wei Cheng Source Type: research
Senescence of bone marrow mesenchymal stem cells in Wistar male rats receiving normal chow/high-calorie diets with/without vitamin D
This study aimed to examine the effects of a high-calorie diet (HCD) with/without vitamin D on BM-MSCs senescence. In the first phase, 48 middle-aged rats were fed a normal chow diet (NCD, n = 24) and an HCD (n = 24) for 26 weeks. Afterward, the rats in each group were randomly divided into three equal subgroups. Immediately, eight-rat from each diet group were sacrificed to assess the HCD effects on the first phase measurements. In the second phase, the remaining 4 groups of rats were fed either NCD or HCD with (6 IU/g) or without vitamin D (standard intake: 1 IU/g); in other words, in this phase, the animals were fed (a)...
Source: Biogerontology - August 22, 2023 Category: Geriatrics Authors: Fahimeh Agh Seyed Hadi Mousavi Naheed Aryaeian Fatemehsadat Amiri Mohammad Reza Jalilvand Motahareh Hasani Farhad Vahid Fatemeh Sepahvand Mehran Vosugh Source Type: research
Allogeneic Adipose-Derived Mesenchymal Stem Cell Transplantation Alleviates Atherosclerotic Plaque by Inhibiting Ox-LDL Uptake, Inflammatory Reaction and Endothelial Damage in Rabbits
In this study, the early treatment effect and preliminary mechanism analysis of allogeneic rabbit ADSCs intravenous transplantation were investigated in a high-fat diet rabbit model. The polarization mechanism of rabbit ADSCs on the macrophage was further analyzed in vitro. Compared with the model group, blood lipid levels declined, the plaque area, oxidized low-density lipoprotein (ox-LDL) uptake, scavenger receptor A1 and cluster of differentiation (CD) 36 levels were all significantly reduced, and the accumulation of inflammatory M1 macrophages, apoptosis, interleukin (IL)-6 and tumor necrosis factor (TNF)-α expression...
Source: Atherosclerosis - August 11, 2023 Category: Cardiology Authors: Yanhong Li Guiying Shi Wei Liang Haiquan Shang Huiwu Li Yunlin Han Wenjie Zhao Lin Bai Chuan Qin Source Type: research
Linking the Mechanics of Chewing to Biology of the Junctional Epithelium
J Dent Res. 2023 Aug 9:220345231185288. doi: 10.1177/00220345231185288. Online ahead of print.ABSTRACTThe capacity of a tissue to continuously alter its phenotype lies at the heart of how an animal is able to quickly adapt to changes in environmental stimuli. Within tissues, differentiated cells are rigid and play a limited role in adapting to new environments; however, differentiated cells are replenished by stem cells that are defined by their phenotypic plasticity. Here we demonstrate that a Wnt-responsive stem cell niche in the junctional epithelium is responsible for the capability of this tissue to quickly adapt to c...
Source: Cell Research - August 9, 2023 Category: Cytology Authors: X Yuan B Liu P Cuevas J Brunski F Aellos J Petersen T Koehne S Br öer R Gr über A LeBlanc X Zhang Q Xu J A Helms Source Type: research
Short-term western diet causes rapid and lasting alterations of bone marrow physiology
Thromb Haemost. 2023 Aug 7. doi: 10.1055/a-2149-4431. Online ahead of print.ABSTRACTDietary factors have a significant impact on overall health and western diet (WD) disrupts arterial homeostasis, thereby promoting atherosclerosis. In our study, we investigated the effects of short-term WD on bone marrow vasculature and hematopoiesis in hypercholesterolemic mice. We found that WD rapidly remodels bone marrow arterioles, and these alterations persist even after WD cessation. The proximity between hematopoietic stem cells (HSCs) and arterioles increased with short-term WD, which was associated with a reduced HSC counts as we...
Source: Atherosclerosis - August 7, 2023 Category: Cardiology Authors: Mariaelvy Bianchini Zoe Moeller-Ramon Christian Weber Remco Megens Johan Duchene Source Type: research
