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Therapy: Gene Therapy
Nutrition: Calcium
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Total 41 results found since Jan 2013.
Future treatments in hypertension: Can we meet the unmet needs of patients?
Eur J Intern Med. 2023 Jun 16:S0953-6205(23)00201-7. doi: 10.1016/j.ejim.2023.06.008. Online ahead of print.ABSTRACTThe prevalence of arterial hypertension is approximately 47% in the United States and 55% in Europe. Multiple different medical therapies are used to treat hypertension including diuretics, beta blockers, calcium channel blockers, angiotensin receptor blockers, angiotensin converting enzyme inhibitors, alpha blockers, central acting alpha receptor agonists, neprilysin inhibitors and vasodilators. However, despite the numerous number of medications, the prevalence of hypertension is on the rise, a considerable...
Source: European Journal of Internal Medicine - June 17, 2023 Category: Internal Medicine Authors: Mehmet Kanbay Sidar Copur Cem Tanriover Duygu Ucku Luke Laffin Source Type: research
Downregulation of striatal Ca < sub > V < /sub > 1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age
Neurobiol Dis. 2023 Mar 29:106111. doi: 10.1016/j.nbd.2023.106111. Online ahead of print.ABSTRACTIn the past 25 years, the prevalence of Parkinson's disease (PD) has nearly doubled. Age remains the primary risk factor for PD and as the global aging population increases this trend is predicted to continue. Even when treated with levodopa, the gold standard dopamine (DA) replacement therapy, individuals with PD frequently develop therapeutic side effects. Levodopa-induced dyskinesia (LID), a common side effect of long-term levodopa use, represents a significant unmet clinical need in the treatment of PD. Previously, in young...
Source: Neurobiology of Disease - March 31, 2023 Category: Neurology Authors: Margaret E Caulfield Molly J Vander Werp Jennifer A Stancati Timothy J Collier Caryl E Sortwell Ivette M Sandoval Fredric P Manfredsson Kathy Steece-Collier Source Type: research
Emerging Promise of the Therapeutic Approaches of Mitochondria for Neurodegenerative Disorders
Curr Neuropharmacol. 2023 Mar 16. doi: 10.2174/1570159X21666230316150559. Online ahead of print.ABSTRACTMitochondria are critical for homeostasis and metabolism in all cellular eukaryotes. Brain mitochondria are the primary source of fuel that supports many brain functions, including intracellular energy supply, cellular calcium regulation, regulation of limited cellular oxidative capacity, and control of cell death. Much evidence suggests that mitochondria play a central role in neurodegenerative disorders (NDDs) such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. Ong...
Source: Current Neuropharmacology - March 17, 2023 Category: Drugs & Pharmacology Authors: Md Mominur Rahman Afroza Alam Tumpa Md Saidur Rahaman Fahadul Islam Popy Rani Sutradhar Muniruddin Ahmed Badrah S Alghamdi Abdul Hafeez Athanasios Alexiou Asma Perveen Ghulam Md Ashraf Source Type: research
Molecular and cellular changes in the post-traumatic spinal cord remodeling after autoinfusion of a genetically-enriched leucoconcentrate in a mini-pig model
Neural Regen Res. 2023 Jul;18(7):1505-1511. doi: 10.4103/1673-5374.360241.ABSTRACTPost-traumatic spinal cord remodeling includes both degenerating and regenerating processes, which affect the potency of the functional recovery after spinal cord injury (SCI). Gene therapy for spinal cord injury is proposed as a promising therapeutic strategy to induce positive changes in remodeling of the affected neural tissue. In our previous studies for delivering the therapeutic genes at the site of spinal cord injury, we developed a new approach using an autologous leucoconcentrate transduced ex vivo with chimeric adenoviruses (Ad5/35)...
Source: Cell Research - December 26, 2022 Category: Cytology Authors: Maria Aleksandrovna Davleeva Ravil Rasimovich Garifulin Farid Vagizovich Bashirov Andrei Aleksandrovich Izmailov Leniz Faritovich Nurullin Ilnur Ildusovich Salafutdinov Dilara Zilbarovna Gatina Dmitrij Nikolaevich Shcherbinin Andrei Aleksandrovich Lysenko Source Type: research
Disrupted T-tubular network accounts for asynchronous calcium release in MTM1 deficient skeletal muscle
This article is protected by copyright. All rights reserved.PMID:36408764 | DOI:10.1113/JP283650
Source: The Journal of Physiology - November 21, 2022 Category: Physiology Authors: Peter Szentesi Beatrix Dienes Candice Kutchukian Tamas Czirjak Ana Buj-Bello Vincent Jacquemond Laszlo Csernoch Source Type: research
Uncovering a new route to pain therapy
Cell Calcium. 2022 Aug 2;106:102635. doi: 10.1016/j.ceca.2022.102635. Online ahead of print.ABSTRACTHigh-voltage-activated calcium channels (HVACCs) are promising targets for developing analgesics given their roles in controlling synaptic transmission, neuronal excitability and neuropeptide release in primary nociceptive neurons. Despite previous efforts in developing HVACCs inhibitors of various drug modalities, it remains undetermined whether targeting HVACCs directly by a gene therapy approach could lead to pain alleviation in vivo. To test this, Sun and colleagues adopted a post-translational ubiquitination-based knock...
Source: Cell Calcium - August 9, 2022 Category: Cytology Authors: Xiangyu Ren Han-Xiong Bear Zhang Source Type: research
