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Specialty: Cytology
Nutrition: Calcium
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Total 2805 results found since Jan 2013.
Molecular architecture of TMEM63 mechanosensitive ion channels
Cell Calcium. 2023 Sep 11;115:102798. doi: 10.1016/j.ceca.2023.102798. Online ahead of print.NO ABSTRACTPMID:37729772 | DOI:10.1016/j.ceca.2023.102798
Source: Cell Calcium - September 20, 2023 Category: Cytology Authors: Jed T Syrenne Parshuram J Sonawane Swetha E Murthy Source Type: research
Machine learning-based mortality prediction in hip fracture patients using biomarkers
J Orthop Res. 2023 Sep 20. doi: 10.1002/jor.25675. Online ahead of print.ABSTRACTThe purpose of this retrospective study was to assess whether mortality following a hip fracture can be predicted by a machine learning model trained on basic blood and lab test data as well as basic demographic data. Additionally, the purpose was to identify the key variables most associated with 1-, 5-, and 10-year mortality and investigate their clinical significance. Input data included 3751 hip fracture patient records sourced from the Medical Information Mart for Intensive Care IV database, which provided records from in-hospital databas...
Source: Cell Research - September 20, 2023 Category: Cytology Authors: George Asrian Abhinav Suri Chamith Rajapakse Source Type: research
Phytohormones regulate asexual Toxoplasma gondii replication
Parasitol Res. 2023 Sep 19. doi: 10.1007/s00436-023-07968-3. Online ahead of print.ABSTRACTThe protozoan Toxoplasma gondii (T. gondii) is a zoonotic disease agent causing systemic infection in warm-blooded intermediate hosts including humans. During the acute infection, the parasite infects host cells and multiplies intracellularly in the asexual tachyzoite stage. In this stage of the life cycle, invasion, multiplication, and egress are the most critical events in parasite replication. T. gondii features diverse cell organelles to support these processes, including the apicoplast, an endosymbiont-derived vestigial plastid ...
Source: Cell Research - September 19, 2023 Category: Cytology Authors: Tina Wagner Berit Bangoura Stefanie Wiedmer Arwid Daugschies Ildiko Rita Dunay Source Type: research
Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signalling by lncRNA < em > Tug1 < /em > in cardiomyocytes
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00339.2023. Online ahead of print.ABSTRACTCardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca2+ levels and consists of pore-forming proteins including MCU, and various regulatory proteins such as mitochondrial calcium uptake proteins 1 and 2 (MICU1/2). The stoichiometry of these proteins influences the sensitivity to Ca2+ and activity of the complex. However, the factors that regulate their gene expression remain incompletely understood. Long non-coding RNAs (lncRNAs)...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Adam J Trewin Kate L Weeks Glenn D Wadley S éverine Lamon Source Type: research
Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina
In this study, we examined by Western blot the expression of TRPC1 in healthy control rat retinas (Sprague-Dawley, SD) and retinas with RP (P23H-1 rats). We also analyzed its specific cellular distribution by immunofluorescence to recognize changes during neurodegeneration and to determine whether its presence is consistent with high basal calcium levels and cellular survival in degenerating retinas. We found that TRPC1 immunostaining was widely distributed across the retina in both rat strains, SD and P23H, and its expression levels significantly increased in the retinas with advanced degeneration compared to the age-cont...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Elena Caminos Marina Murillo-Mart ínez Mar ía García-Belando Jos é Julio Cabanes-Sanchís Juan R Martinez-Galan Source Type: research
Protective effect of cornuside on OGD/R injury in SH-SY5Y cells and its underlying mechanism
In this study, we treated SH-SY5Y cells with OGD/R to simulated ischemia/reperfusion (I/R) injury. Using high-throughput transcriptome sequencing, differentially expressed genes were analyzed in the OGD/R group versus the OGD/R + Cornuside (10 μmol/L) group to explore the neuroprotective mechanisms of Cornuside. The differentially expressed genes were mainly enriched in apoptosis signaling pathway, cell cycle, DNA damage and repair, and p38/JNK MAPK and p53 signaling pathways. The results showed that OGD/R significantly reduced the survival of SH-SY5Y cells, induced apoptosis, disrupted the nucleus, promoted the release o...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Xinyu Wang Chao Yan Chaoyun Wang Xiaoyan Xu Zhihao Liu Wang Xin Jianwei Gong Source Type: research
Regulation of mitochondrial calcium uniporter expression and calcium-dependent cell signalling by lncRNA < em > Tug1 < /em > in cardiomyocytes
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00339.2023. Online ahead of print.ABSTRACTCardiomyocyte calcium homeostasis is a tightly regulated process. The mitochondrial calcium uniporter (MCU) complex can buffer elevated cytosolic Ca2+ levels and consists of pore-forming proteins including MCU, and various regulatory proteins such as mitochondrial calcium uptake proteins 1 and 2 (MICU1/2). The stoichiometry of these proteins influences the sensitivity to Ca2+ and activity of the complex. However, the factors that regulate their gene expression remain incompletely understood. Long non-coding RNAs (lncRNAs)...
Source: Am J Physiol Cell Ph... - September 18, 2023 Category: Cytology Authors: Adam J Trewin Kate L Weeks Glenn D Wadley S éverine Lamon Source Type: research
Sirtuin1 inhibits calcium oxalate crystal-induced kidney injury by regulating TLR4 signaling and macrophage-mediated inflammatory activation
Cell Signal. 2023 Sep 15:110887. doi: 10.1016/j.cellsig.2023.110887. Online ahead of print.ABSTRACTSirtuin1 (Sirt1) activation significantly attenuated calcium oxalate (CaOx) crystal deposition and renal inflammatory injury by regulating renal immune microenvironment. Here, to elucidate the molecular mechanism underlying the therapeutic effects of Sirt1 on macrophage related inflammation and tubular epithelial cells (TECs) necrosis, we constructed a macrophage and CaOx monohydrate (COM)-stimulated tubular cell co-culture system to mimic immune microenvironment in kidney and established a mouse model of CaOx nephrocalcinosi...
Source: Cellular Signalling - September 17, 2023 Category: Cytology Authors: Chen Duan Haoran Liu Xiaoqi Yang Jianhe Liu Yaoliang Deng Tao Wang Jinchun Xing Zhiquan Hu Hua Xu Source Type: research
