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Non-interfacial self-assembly of synthetic protocells
CONCLUSION: This synthetic protocell fabricated by the NISA method simulates the occurrence and development process of primitive life, which has great potential application value in mRNA vaccine, cancer immunotherapy, and drug delivery.PMID:37400932 | DOI:10.1186/s40824-023-00402-w
Source: Cell Research - July 3, 2023 Category: Cytology Authors: Xiaolin Xu Wencai Guan Xiaolei Yu Guoxiong Xu Chenglong Wang Source Type: research

Bioinspired nano-vaccine construction by antigen pre-degradation for boosting cancer personalized immunotherapy
Biomaterials. 2022 Jun 8;287:121628. doi: 10.1016/j.biomaterials.2022.121628. Online ahead of print.ABSTRACTCancer vaccines-based cancer immunotherapy has drawn widespread concern. However, insufficient cancer antigens and inefficient antigen presentation lead to low immune response rate, which greatly restrict the practical application of cancer vaccines. Here, inspired by intracellular proteasome-mediated protein degradation pathway, we report an antigen presentation simplification strategy by extracellular degradation of antigen proteins into peptides with proteolytic enzyme for improving the utilization of cancer antig...
Source: Biomaterials - June 15, 2022 Category: Materials Science Authors: Qiu-Ling Zhang Sheng Hong Xue Dong Di-Wei Zheng Jun-Long Liang Xue-Feng Bai Xia-Nan Wang Zi-Yi Han Xian-Zheng Zhang Source Type: research

Nanovaccine biomineralization for cancer immunotherapy: a NADPH oxidase-inspired strategy for improving antigen cross-presentation via lipid peroxidation
Biomaterials. 2021 Aug 25;277:121089. doi: 10.1016/j.biomaterials.2021.121089. Online ahead of print.ABSTRACTCurrent efforts to develop novel vaccine nanotechnologies to increase cytotoxic T lymphocytes have met the challenges of the limited efficacy of antigen cross-presentation. Recent studies have uncovered a unique biological mechanism by which activation of the NADPH oxidase 2 (NOX2) complex, a major source of reactive oxygen species (ROS), enhances the cross-presentation by antigen-presenting cells (APCs). Inspired by the NOX2 mechanism, we devise biomineralized nanovaccines named NVscp, which are developed by in sit...
Source: Biomaterials - September 4, 2021 Category: Materials Science Authors: Runping Su Gaowei Chong Haiqing Dong Jingjing Gu Jie Zang Ruiqing He Juanjuan Sun Tingting Zhang Yuge Zhao Xiao Zheng Yan Yang Yan Li Yongyong Li Source Type: research

A Unique Family of Neuronal Signaling Proteins Implicated in Oncogenesis and Tumor Suppression
Markus Hartl* and Rainer Schneider Center of Molecular Biosciences (CMBI), Institute of Biochemistry, University of Innsbruck, Innsbruck, Austria The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed in the growth cones of nerve cells where they are involved in signal transmission and cytoskeleton organization. Although their primary structures are unrelated, these signaling proteins share several structural properties like fatty acid modification, and the presence of cationic effector domains. GAP43, MARCKS, and BASP1 bind to cell membrane phospholipids, a process reversibly regulate...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

Navigating the Treatment Landscape
for Advanced-stage Kidney Cancer Mayer N. Fishman, MD, PhD For the patient with advanced-stage kidney cancer, deciding on a course of treatment presents diverse choices. The physician must weigh how quickly the cancer is spreading, the pattern of that spread, and relative risks from other medical conditions against the patient’s individual treatment goals and medical needs. In many cases of patients with advanced disease, there are therapies that can realistically be used to meet the goals of longer survival, longer time to disease progression, and tumor shrinkage. While choosing a kidney cancer treatment can be a...
Source: Kidney Cancer Association - December 3, 2014 Category: Urology & Nephrology Source Type: news

Britain's answer to the Large Hadron Collider
At the Diamond particle accelerator in Oxfordshire, experiments using beams of light 10,000 times brighter than the sun have implications for the fight against cancer, improved air safety and energy efficiencyThe darling of particle physics might be the Large Hadron Collider (LHC) at Cern, but as a practical tool it's no match for the UK's Diamond Light Source. Located on the rapidly growing National Physical Laboratory campus at Harwell in Oxfordshire, Diamond is an alchemist's dream, a place where beams of light 10,000 times brighter than the sun are deployed to probe the nature of everyday things.Diamond is the Marmite ...
Source: Guardian Unlimited Science - February 1, 2014 Category: Science Authors: Brian Clegg Tags: Particle physics Foot and mouth Features Cancer Immunology Cern The Observer Pollution Chemistry Science Source Type: news