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Allergic reactions to tick saliva components in zebrafish model
Alpha-Gal syndrome (AGS) is a tick-borne food allergy caused by IgE antibodies against the glycan galactose-alpha-1,3-galactose ( α-Gal) present in glycoproteins and glycolipids from mammalian meat. To advance ...
Source: Parasites and Vectors - July 19, 2023 Category: Microbiology Authors: Marinela Contreras, Rita Vaz-Rodrigues, Lorena Mazuecos, Margarita Villar, Sara Artigas-Jer ónimo, Almudena González-García, Nadezhda V. Shilova, Nicolai V. Bovin, Sandra Díaz-Sánchez, Elisa Ferreras-Colino, Iván Pacheco, Jindřich Chmelař, Petr Ko Tags: Research Source Type: research

Ticks Carry More Diseases Than Just Lyme. Here ’ s What You Need to Know
Chris Rose lost ten years of his health—not to mention his gallbladder—to a single tick bite. The tick bit in 2010 and Rose, now a 50-year-old network engineer in Chapel Hill, N.C., thought little of it at the time. “It was one of those lone star ticks,” he says, “and I just picked it off me. It wasn’t a big deal.” Before long, however, Rose began developing crushing chest pains, abdominal discomfort, diarrhea, and other symptoms. Doctors screened him for heart disease, irritable bowel syndrome, and gallstones, and even removed his gallbladder to see if that might ease the intesti...
Source: TIME: Health - April 5, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized Disease healthscienceclimate Source Type: news

Ascaris lumbricoides and ticks associated with sensitization to galactose α1,3-galactose and elicitation of the alpha-gal syndrome
IgE to galactose alpha-1,3 galactose (alpha-gal) causes alpha-gal syndrome (delayed anaphylaxis after ingestion of mammalian meat). Development of sensitization has been attributed to tick bites; however, the possible role of other parasites has not been well studied.
Source: Journal of Allergy and Clinical Immunology - July 28, 2021 Category: Allergy & Immunology Authors: Tatenda Murangi, Prema Prakash, Bernardo Pereira Moreira, Wisdom Basera, Maresa Botha, Stephen Cunningham, Heidi Facey-Thomas, Ali Halajian, Lokesh Joshi, Jordache Ramjith, Franco H. Falcone, William Horsnell, Michael E. Levin Source Type: research

α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: Relation to diet, parasites, and IgG4
IgE to α-Gal is a cause of mammalian meat allergy and has been linked to tick bites in North America, Australia, and Eurasia. Reports from the developing world indicate that α-Gal sensitization is prevalent but has been little investigated.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jeffrey M. Wilson, Behnam Keshavarz, Hayley R. James, Maya K.C. Retterer, Alexander J. Schuyler, Alice Knoedler, Lisa J. Workman, Lucy Ng ’ang’a, Martha E. Chico, Eva Rönmark, Peter W. Heymann, Matthew S. Perzanowski, Thomas A.E. Platts-Mills, Philip Source Type: research

α-Gal specific-IgE prevalence and levels in Ecuador and Kenya: relation to diet, parasites and IgG4
In tropical areas of the developing world IgE to α-Gal is prevalent and associated with Ascaris exposure, but represents a minor fraction of total IgE in comparison to meat allergic patients from the USA.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Jeffrey Wilson, Behnam Keshavarz, Hayley James, Maya Retterer, Alexander Schuyler, Alice Knoedler, Lisa Workman, Lucy Ng ’ang’a, Martha E. Chico, Eva Rönmark, Peter Heymann, Matthew Perzanowski, Thomas Platts-Mills, Phillip Cooper Source Type: research

From “Serum Sickness” to “Xenosialitis”: Past, Present, and Future Significance of the Non-human Sialic Acid Neu5Gc
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human dis...
Source: Frontiers in Immunology - April 16, 2019 Category: Allergy & Immunology Source Type: research

The Best —and Worst—Ways to Remove a Tick From Your Skin
This article originally appeared on Health.com
Source: TIME: Health - May 17, 2018 Category: Consumer Health News Authors: Amanda MacMillan / Health.com Tags: Uncategorized healthytime onetime public health Source Type: news

Oh, Lovely: The Tick That Gives People Meat Allergies Is Spreading
By Megan Molteni for WIRED. First comes the unscratchable itching, and the angry blossoming of hives. Then stomach cramping, and — for the unluckiest few — difficulty breathing, passing out, and even death. In the last decade and a half, thousands of previously protein-loving Americans have developed a dangerous allergy to meat. And they all have one thing in common: the lone star tick. Red meat, you might be surprised to know, isn’t totally sugar-free. It contains a few protein-linked saccharides, including one called galactose-alpha-1,3-galactose, or alpha-gal, for short. More and more people are lear...
Source: Healthy Living - The Huffington Post - June 20, 2017 Category: Consumer Health News Source Type: news