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Specialty: Drugs & Pharmacology
Infectious Disease: Influenza
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Total 378 results found since Jan 2013.
Deadly interactions: synergistic manipulations of concurrent pathogen infections potentially enabling future pandemics
Drug Discov Today. 2023 Sep 1:103762. doi: 10.1016/j.drudis.2023.103762. Online ahead of print.ABSTRACTCertain monoinfections of influenza viruses and novel coronaviruses, including severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) are significant threats to human health. Concurrent infections by influenza viruses and coronaviruses increases their threat. Influenza viruses have eight manipulations capable of assisting SARS-CoV-2 and other coronaviruses, and several of these manipulations, which are not specific to viruses, can also directly or indirectly boost dangerous secondary bacterial pneumonias. The influe...
Source: Drug Discovery Today - September 3, 2023 Category: Drugs & Pharmacology Authors: Kevin Roe Source Type: research
Impact of methotrexate treatment on vaccines immunogenicity in adult rheumatological patients - Lessons learned from the COVID-19 pandemic
Biomed Pharmacother. 2023 Aug 3;165:115254. doi: 10.1016/j.biopha.2023.115254. Online ahead of print.ABSTRACTDespite the development of new biological and synthetic targeted therapies, methotrexate remains one of the most commonly used immunomodulatory drugs in rheumatology. However, its effect on the immunogenicity of vaccines has been studied only to a limited extent until recently, resulting in the lack of clear guidelines on the use of methotrexate during vaccination. Significant progress was made during the COVID-19 pandemic due to the dynamic development of research on vaccines, including patients with autoimmune inf...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 5, 2023 Category: Drugs & Pharmacology Authors: Jakub Wro ński Marzena Ciechomska Ewa Kuca-Warnawin Source Type: research
Treatment and prevention of influenza in geriatric patients
Expert Rev Clin Pharmacol. 2023 Aug 1. doi: 10.1080/17512433.2023.2243221. Online ahead of print.ABSTRACTINTRODUCTION: Older adults are the most vulnerable population to the effects of influenza. These patients have age-related characteristics that make response to both infection and therapeutics different than younger patients.AREAS COVERED: Influenza vaccination and antiviral therapy are the foundational approach to preventing and treating influenza in geriatric patients. Older adults should receive one of three enhanced vaccines before influenza season beings. There are five antivirals used in influenza. Geriatric patie...
Source: Pharmacological Reviews - August 1, 2023 Category: Drugs & Pharmacology Authors: Marilyn N Bulloch Source Type: research
Understanding the Global Burden of Influenza in Adults Aged 18 –64 years: A Systematic Literature Review from 2012 to 2022
ConclusionsHigh levels of hospitalization and outpatient visits demonstrated a clinical influenza-associated burden on patients and healthcare systems, which is exacerbated by comorbidities. Considering the size and breadth of the general population aged 18 –64 years, the limited humanistic and economic findings of this SLR likely reflect an underreported burden. Greater investigation into indirect costs and prolonged absenteeism associated with influenza infection is required to fully understand the economic burden in this population.
Source: Advances in Therapy - July 20, 2023 Category: Drugs & Pharmacology Source Type: research
Biomaterial-based delivery platforms for transdermal immunotherapy
Biomed Pharmacother. 2023 Jun 27;165:115048. doi: 10.1016/j.biopha.2023.115048. Online ahead of print.ABSTRACTNowadays, immunotherapy is one of the most essential treatments for various diseases and a broad spectrum of disorders are assumed to be treated by altering the function of the immune system. For this reason, immunotherapy has attracted a great deal of attention and numerous studies on different approaches for immunotherapies have been investigated, using multiple biomaterials and carriers, from nanoparticles (NPs) to microneedles (MNs). In this review, the immunotherapy strategies, biomaterials, devices, and disea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 29, 2023 Category: Drugs & Pharmacology Authors: Mohammad Dahri Nima Beheshtizadeh Nasrin Seyedpour Amin Nakhostin-Ansari Faezeh Aghajani Simin Seyedpour Moein Masjedi Fatemeh Farjadian Reza Maleki Khosro Adibkia Source Type: research
Anti-influenza activity of povidone-iodine-integrated materials
Biol Pharm Bull. 2023 Jun 23. doi: 10.1248/bpb.b23-00161. Online ahead of print.ABSTRACTPersonal protective equipment (PPE), including medical masks, should be worn for preventing the transmission of respiratory pathogens via infective droplets and aerosols. In medical masks, the key layer is the filter layer, and the melt-blown nonwoven fabric (NWF) is the most used fabric. However, the NWF filter layer cannot kill or inactivate the pathogens spread via droplets and aerosols. Povidone-iodine (PVP-I) has been used as an antiseptic solution given its potent broad-spectrum activity against pathogens. To develop PPE (e.g., me...
Source: Biological and Pharmaceutical Bulletin - June 26, 2023 Category: Drugs & Pharmacology Authors: Masaki Shoji Kenta Ichihashi Nongluk Sriwilaijaroen Haruka Mayumi Shinji Morikane Etsuhisa Takahashi Hiroshi Kido Yasuo Suzuki Kazuyoshi Takeda Takashi Kuzuhara Source Type: research
Study on The Interaction Between Silibinin and Neuraminidase
CONCLUSION: Silibinin can interact with neuraminidase and inhibit its activity.PMID:37190805 | DOI:10.2174/1381612829666230515165041
Source: Current Pharmaceutical Design - May 16, 2023 Category: Drugs & Pharmacology Authors: Haowen Fang Yanting Ding Yi Lu Bing Niu Han Lu Qin Chen Source Type: research
