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Infectious Disease: Influenza
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Total 22078 results found since Jan 2013.
Deadly interactions: synergistic manipulations of concurrent pathogen infections potentially enabling future pandemics
Drug Discov Today. 2023 Sep 1:103762. doi: 10.1016/j.drudis.2023.103762. Online ahead of print.ABSTRACTCertain monoinfections of influenza viruses and novel coronaviruses, including severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) are significant threats to human health. Concurrent infections by influenza viruses and coronaviruses increases their threat. Influenza viruses have eight manipulations capable of assisting SARS-CoV-2 and other coronaviruses, and several of these manipulations, which are not specific to viruses, can also directly or indirectly boost dangerous secondary bacterial pneumonias. The influe...
Source: Drug Discovery Today - September 3, 2023 Category: Drugs & Pharmacology Authors: Kevin Roe Source Type: research
The role of pneumococcal vaccination in reducing the cardiovascular risk of cardiac patients: opinion of experts of the Prevention Committee of the Polish Cardiac Society supported by the Polish Vaccinology Society
Kardiol Pol. 2023 Sep 3. doi: 10.33963/v.kp.96718. Online ahead of print.ABSTRACTRespiratory diseases have been the fourth most common cause of death in Poland in recent years. Respiratory infection, especially pneumonia, can lead to exacerbation of chronic cardiovascular disease. Streptococcus pneumoniae is the most common bacterial pathogen causing community-acquired pneumonia. Pneumococci are also the most common pathogen complicating the course of influenza virus infection. Pneumonia, especially invasive pneumococcal disease, is associated with the risk of death in the course of respiratory failure or sepsis and also w...
Source: Kardiologia Polska - September 3, 2023 Category: Cardiology Authors: Artur Mamcarz Marcin We łnicki Jaros ław Drożdż Marcin Grabowski Piotr Jankowski Ernest Kuchar Przemys ław Leszek Przemys ław Mitkowski Jacek Wysocki Source Type: research
Developmental and reproductive safety of Advax-CpG55.2 ™ adjuvanted COVID-19 and influenza vaccines in mice
Vaccine. 2023 Aug 31:S0264-410X(23)01007-1. doi: 10.1016/j.vaccine.2023.08.053. Online ahead of print.ABSTRACTSpikoGen® is a recombinant spike protein vaccine against COVID-19 that obtained marketing authorization in the Middle East on October 6th, 2021, becoming the first adjuvanted protein-based COVID-19 vaccine of its type to achieve approval. SpikoGen® vaccine utilizes a unique adjuvant Advax-CpG55.2, which comprises delta inulin and CpG55.2 oligonucleotide, a synthetic human toll-like receptor (TLR)-9 agonist. As part of a safety assessment, developmental and reproductive toxicity (DART) studies were undertaken in m...
Source: Vaccine - September 2, 2023 Category: Allergy & Immunology Authors: Isaac G Sakala Yoshikazu Honda-Okubo Nikolai Petrovsky Source Type: research
Immunogenicity and protective efficacy of human metapneumovirus virus-like particles produced by a recombinant baculovirus in mice
CONCLUSIONS: This is the first study to demonstrate that HMPV VLP was successfully prepared in the baculovirus expression system. HMPV VLP could induce specific humoral and cellular immune responses as well as protective efficacy, and aluminum hydroxide may be an effective adjuvant in mice.PMID:37657510 | DOI:10.1016/j.virusres.2023.199215
Source: Virus Research - September 1, 2023 Category: Virology Authors: Fenlian Ma Aijun Chen Lihong Yao Hanchun Gao Qian Zhang Wenzhe Hou Lishu Zheng Source Type: research
Characterization of novel, severely immunodeficient Prkdc < sup > Δex57/Δex57 < /sup > mice
Biochem Biophys Res Commun. 2023 Aug 26;678:193-199. doi: 10.1016/j.bbrc.2023.08.055. Online ahead of print.ABSTRACTSeverely immunodeficient mice are useful for understanding the pathogenesis of certain tumors and for developing therapeutic agents for such tumors. In addition, engraftment of these mice with human hematopoietic cells can yield information that helps us understand the in vivo molecular mechanisms underlying actual human viral infections. In our present research, we discovered a novel, severely immunodeficient strain of mice having a mutation in exon 57 of the Prkdc gene (PrkdcΔex57/Δex57) in an inbred colo...
Source: Biochemical and Biophysical Research communications - August 31, 2023 Category: Biochemistry Authors: Yumie Takagi Katsuko Sudo Sachiko Yamaguchi Shuzo Urata Tatsukuni Ohno Sachiko Hirose Kiyoshi Matsumoto Takashi Kuramoto Tadao Serikawa Jiro Yasuda Masashi Ikutani Susumu Nakae Source Type: research
