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Infectious Disease: Herpes

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From the pages of AllergyWatch
For this month's issue of Annals, which focuses on vaccines, there are 3 article summaries from recent AllergyWatch columns that reviewed studies on various aspects of vaccines. The first reports data from a pivotal study on the improved efficacy of the new recombinant subunit herpes zoster vaccine. The second review describes a report of a unique vaccine for cats that induces immunoglobulin G –blocking antibodies for Fel d 1. The third review reports discrepant results of pneumococcal titers from different laboratories.
Source: Annals of Allergy, Asthma and Immunology - April 23, 2020 Category: Allergy & Immunology Authors: David A. Khan, Gerald B. Lee, Stanley M. Fineman Tags: Special Series Source Type: research

What Are Potential Complications of Tattooing?
Discussion “Tattooing of skin via deposition of pigment particles and ink ingredients in the dermis changes normal skin into abnormal skin. Fortunately, this often causes no harm and no disease, although with important exceptions.” Tattoos can be inadvertent from road dirt, gunpowder, pencil graphite etc., but most are desired. Tattoos are common in many cultures and over time..They have been increasing in popularity in the United States over the past few years particularly with a younger, wider and more diverse population. Newsweek reported an 18-country study in 2018 which showed 46% of Americans have a tat...
Source: PediatricEducation.org - May 18, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Herpes Zoster Infection With MS Treatment Higher in Women? Herpes Zoster Infection With MS Treatment Higher in Women?
A review of FDA reports also shows notably higher rates of shingles in women among younger patients taking disease-modifying therapies for multiple sclerosis.Medscape Medical News
Source: Medscape Allergy Headlines - June 4, 2020 Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news

Asthma increases the risk of herpes zoster: a nested case –control study using a national sample cohort
This study aimed to complement previous studies on the risk of herpes zoster in the asthmatic adult population.
Source: Allergy, Asthma and Clinical Immunology - June 23, 2020 Category: Allergy & Immunology Authors: So Young Kim, Dong Jun Oh and Hyo Geun Choi Tags: Research Source Type: research

P550 differences in admission complete blood count parameters in eczema herpeticum in children
In this study, we investigated whether complete blood count (CBC) can distinguish EH from AD patients with bacterial infections or exacerbation.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2020 Category: Allergy & Immunology Authors: G. Chan, P. Ong Tags: Skin Disorders Source Type: research

Differential Contribution Of TNFSF14/LIGHT-Receptor Mediated Pathways To Inflammatory Fibroblast Phenotypes In Eosinophilic Esophagitis
Fibroblasts (FBL) mediate tissue remodeling in eosinophilic esophagitis (EoE), a chronic allergen driven inflammatory pathology. We recently defined a putative role of the cytokine TNFSF14/LIGHT as a promoter of an inflammatory esophageal FBL subtype. LIGHT can signal through two receptors, herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LT ßR). We investigated the relative contributions of each receptor to LIGHT-mediated inflammatory FBL differentiation.
Source: Journal of Allergy and Clinical Immunology - February 1, 2021 Category: Allergy & Immunology Authors: Mario Cabrero Manresa, Elaine Pham, Loan Duong, Haruka Miki, Michael Croft, Seema Aceves Source Type: research

Clonal expansion of CD4+CD8+ T cells in an adult patient with Mycoplasma pneumoniae-associated Erythema multiforme majus
Erythema multiforme (EM) is an acute, immune-mediated mucocutaneous disease, most often preceded by herpes simplex virus (HSV) infection or reactivation. Mycoplasma pneumoniae (Mp) is considered the second major ...
Source: Allergy, Asthma and Clinical Immunology - February 10, 2021 Category: Allergy & Immunology Authors: Sarah M. Volkers, Christian Meisel, Dorothea Terhorst-Molawi, Guido J. Burbach, Dirk Sch ürmann, Norbert Suttorp and Leif E. Sander Tags: Case Report Source Type: research

Viral Infections and Cutaneous Drug-Related Eruptions
In the general population, up to 10% of children treated by antibiotics have cutaneous adverse drug reaction, but allergy is confirmed in less than 20% of patients. Most of the non-allergic reactions are probably due to virus, such as enterovirus acute infection or Ebstein-Barr Virus (EBV) acute infection or reactivation. Especially in children, viruses have the propensity to induce skin lesions (maculopapular rash, urticaria) due to their skin infiltration or immunologic response. In drug-related skin eruptions, a virus can participate by activating an immune predisposition. The culprit antibiotic is then the trigger for ...
Source: Frontiers in Pharmacology - March 10, 2021 Category: Drugs & Pharmacology Source Type: research

Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids
We describe that prolonged high-intensity exercise leads to impaired or enhanced immune responses against HSV-2 infection depending on the timing between infection and exercise.
Source: Journal of Allergy and Clinical Immunology - May 6, 2021 Category: Allergy & Immunology Authors: Akimasa Adachi, Tetsuya Honda, Teruki Dainichi, Gyohei Egawa, Yosuke Yamamoto, Takashi Nomura, Saeko Nakajima, Atsushi Otsuka, Masamitsu Maekawa, Nariyasu Mano, Naoto Koyanagi, Yasushi Kawaguchi, Toshiaki Ohteki, Takashi Nagasawa, Koichi Ikuta, Akihiko Ki Source Type: research

Defects of the Innate Immune System and Related Immune Deficiencies
AbstractThe innate immune system is the host ’s first line of defense against pathogens. Toll-like receptors (TLRs) are pattern recognition receptors that mediate recognition of pathogen-associated molecular patterns. TLRs also activate signaling transduction pathways involved in host defense, inflammation, development, and the production of inflammatory cytokines. Innate immunodeficiencies associated with defective TLR signaling include mutations inNEMO,IKBA,MyD88, andIRAK4. Other innate immune defects have been associated with susceptibility to herpes simplex encephalitis, viral infections, and mycobacterial disease, a...
Source: Clinical Reviews in Allergy and Immunology - August 21, 2021 Category: Allergy & Immunology Source Type: research

New Analysis Presented by Janssen at United European Gastroenterology Week (UEGW) Demonstrates Long-Term Safety Profile for STELARA ® (ustekinumab) in Older Patients Across Approved Indications
SPRING HOUSE, PENNSYLVANIA, October 4, 2021 – Today, the Janssen Pharmaceutical Companies of Johnson & Johnson announced a new analysis of STELARA® (ustekinumab) pooled safety data from 13 clinical studies across approved indications, showing rates of key safety events among adults 60 years and older treated with STELARA for up to five yearsa were similar to rates observed with placebo during the control phase of these trials.1,b Approved indications included adults with moderately to severely active Crohn’s disease (CD), moderately to severely active ulcerative colitis (UC), moderate to severe plaque psoriasis (P...
Source: Johnson and Johnson - October 4, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

M002 new-onset rosacea in a patient on dupilumab treatment for nasal polyposis
Dupilumab is a humanized monoclonal antibody that inhibits the interleukin-4 receptor (IL-4R α), thereby blocking IL-4 and IL-13 signaling of the Th2 pathway. Via Th2 blockade, Dupilumab decreases eosinophil recruitment, rendering it an effective treatment for nasal polyps caused by chronic accumulation of eosinophils in the paranasal sinus mucosa. Side effects reported during clinical tri als included conjunctivitis, injection site reactions, and herpes infections.
Source: Annals of Allergy, Asthma and Immunology - November 1, 2021 Category: Allergy & Immunology Authors: J. Fortier, J. Justice, A. Debenedetto, L. Cuervo-Pardo Source Type: research

Janssen Reports Positive Topline Week 48 Phase 2 Results for TREMFYA ® (guselkumab) in Adults With Moderately to Severely Active Crohn's Disease
SPRING HOUSE, PENNSYLVANIA, November 17, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced topline results from the Phase 2 GALAXI 1 clinical trial which showed rates of clinical remission (Crohn’s Disease Activity Index [CDAI]<150) previously reported at week 12 increased at week 48 among adults with moderately to severely active Crohn’s disease (CD) treated with TREMFYA® (guselkumab).1 At week 48, 65 percent of patients receiving TREMFYA achieved clinical remission. TREMFYA is under investigation and not currently approved for the treatment of CD in the U.S.2Janssen previously...
Source: Johnson and Johnson - November 17, 2021 Category: Pharmaceuticals Source Type: news

Acupuncture, Shingles, and Allergen Immunotherapy
Conclusions: Acupuncture is a minor trauma that can predispose a patient to reactivation of VZV and shingles in the setting of immune activation with allergen immunotherapy.PMID:34976278 | PMC:PMC8716517 | DOI:10.1089/acu.2020.1521
Source: Acupuncture in Medicine - January 3, 2022 Category: Complementary Medicine Authors: David McMahon Sushma Kadiyala Irene M Estores Source Type: research