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Infectious Disease: Tuberculosis

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Total 482 results found since Jan 2013.

La Jolla Institute for Allergy and Immunology team receives $18 million consortium grant
(La Jolla Institute for Allergy and Immunology) The La Jolla Institute for Allergy and Immunology (LJI) is pleased to announce that an international team led by LJI investigator Alessandro Sette, Ph.D., is one of four recipients of a Human Immune Profiling Consortium (HIPC) grant in 2015. With this prestigious grant, the LJI team will characterize the immune response to dengue virus (DENV) and Mycobacterium tuberculosis (TB), both of which represent major global health challenges.
Source: EurekAlert! - Infectious and Emerging Diseases - December 17, 2015 Category: Infectious Diseases Source Type: news

Antituberculosis Drug-Associated DRESS: A Case Series
Conclusions We described the largest case series of first-line antituberculosis drug-associated DRESS in the literature. All antituberculosis drugs pose a risk of DRESS. An early withdrawal of the culprit drugs is essential. A drug allergy evaluation must be performed to optimize the second-line treatment of tuberculosis infection.
Source: The Journal of Allergy and Clinical Immunology: In Practice - December 21, 2017 Category: Allergy & Immunology Source Type: research

Research resources for tuberculosis at the National Institute of Allergy and Infectious Diseases
Summary: Global control of tuberculosis (TB) requires the participation of multiple stakeholders that cross the spectrum of biomedical research, product development, and implementation and operational research. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), plays a critical role in TB biomedical research and product development by directly supporting and leveraging other funding support strategies and providing research resources to facilitate the translation of knowledge about TB into strategies and tools to more effectively combat disease. The primary m...
Source: Tuberculosis - February 5, 2013 Category: Respiratory Medicine Authors: NIH, DMID TB program Tags: Special Issue Articles Source Type: research

Correction
With regard to the June 2013 article entitled “Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil” (J Allergy Clin Immunol 2013:131:1683-90), a punctuation error in Reference 25 led to the listing of the first two authors of the article as a single entry. The correct reference is as follows: Abhimanyu, Mangangcha IR, Jha P, Arora K, Mukerji M, et al. Differential serum cytokine levels are associated with cytokine gene polymorphisms in north Indians with active pulmonary tuberculosis. Infect Genet Evol 2011;11:1015-22. The authors regret this error.
Source: Journal of Allergy and Clinical Immunology - September 29, 2013 Category: Allergy & Immunology Tags: Corrections Source Type: research

Epigenetics in Immune-Mediated Pulmonary Diseases.
Abstract Immune-mediated pulmonary diseases are a group of diseases that resulted from immune imbalance initiated by allergens or of unknown causes. Inflammatory responses without restrictions cause tissue damage and remodeling, which leads to airway hyperactivity, destruction of alveolar architecture, and a resultant loss of lung function. Epigenetic mechanisms have been demonstrated to be involved in inflammation, autoimmunity, and cancer. Recent studies have identified that epigenetic changes also regulate molecular pathways in immune-mediated lung diseases. Aberrant DNA methylation status, dysregulation of his...
Source: Clinical Lung Cancer - November 19, 2013 Category: Cancer & Oncology Authors: Liu Y, Li H, Xiao T, Lu Q Tags: Clin Rev Allergy Immunol Source Type: research

Randomised controlled trials in child health in developing countries: trends and lessons over 11 years
Using a uniform systematic approach annually, we reviewed 1553 publications from randomised controlled trials in child health in developing countries published between July 2002 and June 2013. There were annual increases in such publications, from 38 in the 12 months to July 2003 to over 200 in each of 2012 and 2013. These trials involved children in 76 developing countries. Studies of nutrition (366 publications, 23.6%) and malaria (336 publications, 21%) predominated. 79% of nutrition trials have been of micronutrients (288 publications), with comparatively few publications related to macronutrient interventions or ...
Source: Archives of Disease in Childhood - June 12, 2014 Category: Pediatrics Authors: Duke, T., Fuller, D. Tags: Clinical trials (epidemiology), Immunology (including allergy), ADC Global child health, TB and other respiratory infections, Travel medicine, Tropical medicine (infectious diseases), Childhood nutrition, Obesity (nutrition), Reproductive medicine, Child Source Type: research

Got milk? Understanding the farm milk effect in allergy and asthma prevention
Cow's milk is a major component of most of our diets, but concerns about its ingestion have been in and out of public health dialogues for decades. Raw milk has long been associated with numerous foodborne illnesses and outbreaks due to enteric and opportunistic bacteria such as Brucella, Salmonella, Listeria monocytogenes, Yersinia, Campylobactor species, Staphylococcus aureus, and Escherichia coli species.1,2 Mycobacterium bovis infection was transmitted to humans following drinking unpasteurized milk from infected cows, causing tuberculosis and scrofula.
Source: Journal of Allergy and Clinical Immunology - April 11, 2016 Category: Allergy & Immunology Authors: Joyce E. Yu, Rachel L. Miller Tags: Editorial Source Type: research

Sequential rapid oral desensitization to rifampin and moxifloxacin for the treatment of active mycobacterium tuberculosis
Publication date: Available online 9 November 2016 Source:The Journal of Allergy and Clinical Immunology: In Practice Author(s): Scott T. Benken, Sharmilee M. Nyenhuis, Sean Dunne
Source: The Journal of Allergy and Clinical Immunology: In Practice - November 9, 2016 Category: Allergy & Immunology Source Type: research

Analysis of HLA-B allelic variation and interferon-gamma ELISpot responses in patients with severe cutaneous adverse reactions associated with drugs
Conclusions HLA-B pre-screening would succeed in preventing only a minority of SCAR victims. Drug-specific IFN-γ releasing cells are detectable in almost half of patients. Better strategies are required for better SCAR prevention and culprit drug confirmation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - May 23, 2018 Category: Allergy & Immunology Source Type: research

Management of adverse reactions to first-line tuberculosis antibiotics
Purpose of review Tuberculosis (TB) is the commonest infectious cause of death globally. Adverse reactions to first-line tuberculosis antibiotics are common and have a major impact on the outcomes of patients as second-line antibiotics are less effective and more toxic. The present review addresses the most recent literature regarding epidemiology, investigating reactions, and reintroducing treatment in patients who have had their treatment interrupted. Recent findings Studies have demonstrated that up to 60% of patients experience adverse reactions to TB treatment; around a third of these are idiosyncratic and may re...
Source: Current Opinion in Allergy and Clinical Immunology - June 30, 2018 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research

Asthma, sinonasal disease, and the risk of active tuberculosis
ConclusionsA history of asthma or sinonasal disease may modulate immunological response to reduce incidence of active TB in the adult population.
Source: The Journal of Allergy and Clinical Immunology: In Practice - August 19, 2018 Category: Allergy & Immunology Source Type: research

Is there an overlap in immune response between allergic bronchopulmonary and chronic pulmonary aspergillosis?
ConclusionsAbout 5% of subjects with CPA fulfilled all the immunological criteria used for diagnosing ABPA while 22% met the obligatory criteria for ABPA. Whether these patients would require a different management protocol requires further investigation.
Source: The Journal of Allergy and Clinical Immunology: In Practice - September 9, 2018 Category: Allergy & Immunology Source Type: research

Inhaled corticosteroid-related tuberculosis in the real world among patients with asthma and COPD: A 10-year nationwide population-based study
ConclusionAn increased risk of TB development may persist for 3 years after stopping the ICS and the risk is higher in patients with COPD regardless of the type of ICS used.
Source: The Journal of Allergy and Clinical Immunology: In Practice - October 17, 2018 Category: Allergy & Immunology Source Type: research